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Title: AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe

Patent ·
OSTI ID:1185288

An electrospray system comprises a liquid extraction surface sampling probe. The probe comprises a probe body having a liquid inlet and a liquid outlet, and having a liquid extraction tip. A solvent delivery conduit is provided for receiving solvent liquid from the liquid inlet and delivering the solvent liquid to the liquid extraction tip. An open liquid extraction channel extends across an exterior surface of the probe body from the liquid extraction tip to the liquid outlet. An electrospray emitter tip is in liquid communication with the liquid outlet of the liquid extraction surface sampling probe. A system for analyzing samples, a liquid junction surface sampling system, and a method of analyzing samples are also disclosed.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-00OR22725
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
Patent Number(s):
9,064,680
Application Number:
14/265,912
OSTI ID:
1185288
Resource Relation:
Patent File Date: 2014 Apr 30
Country of Publication:
United States
Language:
English

References (14)

Sampling probe for microarray read out using electrospray mass spectrometry patent October 2004
Nanotipped device and method patent July 2007
Focused analyte spray emission apparatus and process for mass spectrometric analysis patent January 2012
Multi-needle multi-parallel nanospray ionization source for mass spectrometry patent June 2012
Planar electronebulization sources modeled on a calligraphy pen and the production thereof patent October 2012
Enclosed desorption electrospray ionization patent-application July 2008
A micro-nib nanoelectrospray source for mass spectrometry journal March 2004
A nanofluidic emitter tip obtained by focused ion beam nanofabrication journal August 2005
Self-aspirating atmospheric pressure chemical ionization source for direct sampling of analytes on surfaces and in liquid solutions journal January 2005
Microfluidic design rules for capillary slot-based electrospray sources journal September 2004
Microfluidics in the “Open Space” for Performing Localized Chemistry on Biological Interfaces journal October 2012
Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry journal December 2011
Scanning probe electrospray ionization for ambient mass spectrometry: SPESI for ambient mass spectrometry journal October 2012
Thin-Layer Chromatography and Electrospray Mass Spectrometry Coupled Using a Surface Sampling Probe journal November 2002

Cited By (1)

AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe patent June 2015

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