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System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis

Patent ·
OSTI ID:1261602
;
A system for sampling a surface includes a surface sampling probe comprising a solvent liquid supply conduit and a distal end, and a sample collector for suspending a sample collection liquid adjacent to the distal end of the probe. A first electrode provides a first voltage to solvent liquid at the distal end of the probe. The first voltage produces a field sufficient to generate electrospray plume at the distal end of the probe. A second electrode provides a second voltage and is positioned to produce a plume-directing field sufficient to direct the electrospray droplets and ions to the suspended sample collection liquid. The second voltage is less than the first voltage in absolute value. A voltage supply system supplies the voltages to the first electrode and the second electrode. The first electrode can apply the first voltage directly to the solvent liquid. A method for sampling for a surface is also disclosed.
Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-00OR22725
Assignee:
UT-BATTELLE, LLC (Oak Ridge, TN)
Patent Number(s):
9,390,901
Application Number:
14/529,307
OSTI ID:
1261602
Country of Publication:
United States
Language:
English

References (9)

Scanning probe electrospray ionization for ambient mass spectrometry: SPESI for ambient mass spectrometry journal October 2012
Imaging mass spectrometry of a mouse brain by tapping-mode scanning probe electrospray ionization journal January 2014
Controlled-Resonant Surface Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging journal March 2014
Liquid Microjunction Surface Sampling Coupled with High-Pressure Liquid Chromatography−Electrospray Ionization-Mass Spectrometry for Analysis of Drugs and Metabolites in Whole-Body Thin Tissue Sections journal July 2010
Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry journal January 2010
Continuous-flow liquid microjunction surface sampling probe connected on-line with high-performance liquid chromatography/mass spectrometry for spatially resolved analysis of small molecules and proteins: LMJ-SPP on-line with HPLC/MS journal May 2013
Automated liquid microjunction surface sampling-HPLC–MS/MS analysis of drugs and metabolites in whole-body thin tissue sections journal April 2013
Ambient DESI and LESA-MS Analysis of Proteins Adsorbed to a Biomaterial Surface Using In-Situ Surface Tryptic Digestion journal September 2013
Combining Laser Ablation/Liquid Phase Collection Surface Sampling and High-Performance Liquid Chromatography−Electrospray Ionization-Mass Spectrometry journal March 2011

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