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Pulsed voltage electrospray ion source and method for preventing analyte electrolysis

Patent ·
OSTI ID:1034105
 [1];  [2]
  1. Knoxville, TN
  2. Clinton, TN
+ Show Author Affiliations
An electrospray ion source and method of operation includes the application of pulsed voltage to prevent electrolysis of analytes with a low electrochemical potential. The electrospray ion source can include an emitter, a counter electrode, and a power supply. The emitter can include a liquid conduit, a primary working electrode having a liquid contacting surface, and a spray tip, where the liquid conduit and the working electrode are in liquid communication. The counter electrode can be proximate to, but separated from, the spray tip. The power system can supply voltage to the working electrode in the form of a pulse wave, where the pulse wave oscillates between at least an energized voltage and a relaxation voltage. The relaxation duration of the relaxation voltage can range from 1 millisecond to 35 milliseconds. The pulse duration of the energized voltage can be less than 1 millisecond and the frequency of the pulse wave can range from 30 to 800 Hz.
Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-00OR22725
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
Patent Number(s):
8,084,735
Application Number:
12/431,461
OSTI ID:
1034105
Country of Publication:
United States
Language:
English

References (8)

Sheathless capillary electrophoresis-mass spectrometry using a pulsed electrospray ionization source journal June 2006
Expanded use of a battery-powered two-electrode emitter cell for electrospray mass spectrometry journal July 2006
Ionic liquid ion sources: suppression of electrochemical reactions using voltage alternation journal December 2004
A New ac Electrospray Mechanism by Maxwell-Wagner Polarization and Capillary Resonance journal April 2004
The use of AC potentials in electrospraying and electrospinning processes journal April 2004
AC electrospray biomaterials synthesis journal November 2005
Pulsed Electrospray for Mass Spectrometry journal October 2001
A high-frequency electrospray driven by gas volume charges journal June 2005

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