skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: An Open Port Sampling Interface for Liquid Introduction Atmospheric Pressure Ionization Mass Spectrometry

Abstract

RATIONALE: A simple method to introduce unprocessed samples into a solvent for rapid characterization by liquid introduction atmospheric pressure ionization mass spectrometry has been lacking. The continuous flow, self-cleaning open port sampling interface introduced here fills this void. METHODS: The open port sampling interface used a vertically aligned, co-axial tube arrangement enabling solvent delivery to the sampling end of the device through the tubing annulus and solvent aspiration down the center tube and into the mass spectrometer ionization source via the commercial APCI emitter probe. The solvent delivery rate to the interface was set to exceed the aspiration rate creating a continuous sampling interface along with a constant, self-cleaning spillover of solvent from the top of the probe. RESULTS: Using the open port sampling interface with positive ion mode APCI and a hybrid quadrupole time of flight mass spectrometer, rapid, direct sampling and analysis possibilities are exemplified with plastics, ballpoint and felt tip ink pens, skin, and vegetable oils. These results demonstrated that the open port sampling interface could be used as a simple, versatile and self-cleaning system to rapidly introduce multiple types of unprocessed, sometimes highly concentrated and complex, samples into a solvent flow stream for subsequent ionization andmore » analysis by mass spectrometry. The basic setup presented here could be incorporated with any self-aspirating liquid introduction ionization source (e.g., ESI, APCI, APPI, ICP, etc.) or any type of atmospheric pressure sampling ready mass spectrometer system. CONCLUSIONS: The open port sampling interface provides a means to introduce and quickly analyze unprocessed solid or liquid samples with liquid introduction atmospheric pressure ionization source without fear of sampling interface or ionization source contamination.« less

Authors:
 [1];  [1]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Organic and Biological Mass Spectrometry Group
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1223662
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Rapid Communications in Mass Spectrometry
Additional Journal Information:
Journal Volume: 29; Journal Issue: 19; Journal ID: ISSN 0951-4198
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; open port sampling interface; liquid introduction; extraction; direct sampling; atmospheric pressure chemical ionization; plastic; ink; skin; vegetable oil

Citation Formats

Van Berkel, Gary J., and Kertesz, Vilmos. An Open Port Sampling Interface for Liquid Introduction Atmospheric Pressure Ionization Mass Spectrometry. United States: N. p., 2015. Web. doi:10.1002/rcm.7274.
Van Berkel, Gary J., & Kertesz, Vilmos. An Open Port Sampling Interface for Liquid Introduction Atmospheric Pressure Ionization Mass Spectrometry. United States. https://doi.org/10.1002/rcm.7274
Van Berkel, Gary J., and Kertesz, Vilmos. Tue . "An Open Port Sampling Interface for Liquid Introduction Atmospheric Pressure Ionization Mass Spectrometry". United States. https://doi.org/10.1002/rcm.7274. https://www.osti.gov/servlets/purl/1223662.
@article{osti_1223662,
title = {An Open Port Sampling Interface for Liquid Introduction Atmospheric Pressure Ionization Mass Spectrometry},
author = {Van Berkel, Gary J. and Kertesz, Vilmos},
abstractNote = {RATIONALE: A simple method to introduce unprocessed samples into a solvent for rapid characterization by liquid introduction atmospheric pressure ionization mass spectrometry has been lacking. The continuous flow, self-cleaning open port sampling interface introduced here fills this void. METHODS: The open port sampling interface used a vertically aligned, co-axial tube arrangement enabling solvent delivery to the sampling end of the device through the tubing annulus and solvent aspiration down the center tube and into the mass spectrometer ionization source via the commercial APCI emitter probe. The solvent delivery rate to the interface was set to exceed the aspiration rate creating a continuous sampling interface along with a constant, self-cleaning spillover of solvent from the top of the probe. RESULTS: Using the open port sampling interface with positive ion mode APCI and a hybrid quadrupole time of flight mass spectrometer, rapid, direct sampling and analysis possibilities are exemplified with plastics, ballpoint and felt tip ink pens, skin, and vegetable oils. These results demonstrated that the open port sampling interface could be used as a simple, versatile and self-cleaning system to rapidly introduce multiple types of unprocessed, sometimes highly concentrated and complex, samples into a solvent flow stream for subsequent ionization and analysis by mass spectrometry. The basic setup presented here could be incorporated with any self-aspirating liquid introduction ionization source (e.g., ESI, APCI, APPI, ICP, etc.) or any type of atmospheric pressure sampling ready mass spectrometer system. CONCLUSIONS: The open port sampling interface provides a means to introduce and quickly analyze unprocessed solid or liquid samples with liquid introduction atmospheric pressure ionization source without fear of sampling interface or ionization source contamination.},
doi = {10.1002/rcm.7274},
url = {https://www.osti.gov/biblio/1223662}, journal = {Rapid Communications in Mass Spectrometry},
issn = {0951-4198},
number = 19,
volume = 29,
place = {United States},
year = {2015},
month = {8}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Citation Metrics:
Cited by: 7 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Infrared Laser Ablation Sample Transfer for MALDI and Electrospray
journal, May 2011


Automation of a Surface Sampling Probe/Electrospray Mass Spectrometry System
journal, November 2005


Mass Spectrometry: Recent Advances in Direct Open Air Surface Sampling/Ionization
journal, January 2013


Ambient laser ablation sampling for capillary electrophoresis mass spectrometry: Ambient laser ablation sampling for CE/MS
journal, June 2013


Self-aspirating atmospheric pressure chemical ionization source for direct sampling of analytes on surfaces and in liquid solutions
journal, January 2005


Mechanisms of Real-Time, Proximal Sample Processing during Ambient Ionization Mass Spectrometry
journal, December 2013


Direct analysis in real time—a critical review on DART-MS
journal, September 2013


Combination Atmospheric Pressure Solids Analysis Probe and Desorption Electrospray Ionization Mass Spectrometry Ion Source
journal, November 2009


Forensic applications of ambient ionization mass spectrometry
journal, February 2009


The Single-Probe: A Miniaturized Multifunctional Device for Single Cell Mass Spectrometry Analysis
journal, September 2014


Analysis of Solids, Liquids, and Biological Tissues Using Solids Probe Introduction at Atmospheric Pressure on Commercial LC/MS Instruments
journal, December 2005


Ambient Infrared Laser Ablation Mass Spectrometry (AIRLAB-MS) of Live Plant Tissue with Plume Capture by Continuous Flow Solvent Probe
journal, February 2015


Established and emerging atmospheric pressure surface sampling/ionization techniques for mass spectrometry
journal, September 2008


Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry
journal, January 2010


Scanning probe electrospray ionization for ambient mass spectrometry: SPESI for ambient mass spectrometry
journal, October 2012


High-Throughput Mode Liquid Microjunction Surface Sampling Probe
journal, August 2009


Liquid Microjunction Surface Sampling Probe Fluid Dynamics: Computational and Experimental Analysis of Coaxial Intercapillary Positioning Effects on Sample Manipulation
journal, April 2011


Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform
journal, March 2010


Transmission geometry laser ablation into a non-contact liquid vortex capture probe for mass spectrometry imaging
journal, June 2014

  • Ovchinnikova, Olga S.; Bhandari, Deepak; Lorenz, Matthias
  • Rapid Communications in Mass Spectrometry, Vol. 28, Issue 15, p. 1665-1673
  • https://doi.org/10.1002/rcm.6946

Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions
journal, April 2005


An enhanced droplet-based liquid microjunction surface sampling system coupled with HPLC-ESI-MS/MS for spatially resolved analysis
journal, November 2014


Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology
journal, October 2005


Electrochemical Push–Pull Scanner with Mass Spectrometry Detection
journal, July 2012


Controlled-Resonant Surface Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging
journal, March 2014


    Works referencing / citing this record:

    Solvent effects on differentiation of mouse brain tissue using laser microdissection ‘cut and drop’ sampling with direct mass spectral analysis
    journal, February 2018


    Application of open port sampling interface mass spectrometry (OPSI‐MS) to deuterium exchange as an aid for structural elucidation
    journal, February 2020