System and process for purification of Astatine-211 from target materials

O'Hara, Matthew J.

System and process for purification of Astatine-211 from target materials

Patent · Tue Apr 04 00:00:00 EDT 2023

OSTI ID:1998263

O'Hara, Matthew J.

A new column-based purification system and approach are described for rapid separation and purification of the alpha-emitting therapeutic radioisotope ²¹¹At from dissolved cyclotron targets that provide highly reproducible product results with excellent ²¹¹At species distributions and high antibody labeling yields compared with prior art manual extraction results of the prior art that can be expected to enable enhanced production of purified ²¹¹At isotope products suitable for therapeutic medical applications such as treatment of cancer in human patients.

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Number(s):: 11,621,097

Application Number:: 17/586,647

OSTI ID:: 1998263

Country of Publication:: United States

Language:: English

References (6)

A simple isolation of 211At using an anion-exchange spin column method Watanabe, Shigeki; Sasaki, Ichiro; Watanabe, Satoshi Journal of Radioanalytical and Nuclear Chemistry, Vol. 326, Issue 2 https://doi.org/10.1007/s10967-020-07422-z	journal	October 2020
An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211 O’Hara, Matthew J.; Krzysko, Anthony J.; Niver, Cynthia M. Applied Radiation and Isotopes, Vol. 122 https://doi.org/10.1016/j.apradiso.2017.02.001	journal	April 2017
Investigation of a tellurium-packed column for isolation of astatine-211 from irradiated bismuth targets and demonstration of a semi-automated system Li, Yawen; Hamlin, Donald K.; Chyan, Ming-Kuan Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-53385-x	journal	November 2019
Automated astatination of biomolecules – a stepping stone towards multicenter clinical trials Aneheim, Emma; Albertsson, Per; Bäck, Tom Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep12025	journal	July 2015
Evaluation of Novel Wet Chemistry Separation and Purification Methods to Facilitate Automation of Astatine-211 Isolation Wilbur, Daniel Scott Report https://doi.org/10.2172/1335515	report	July 2016
Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine Balkin, Ethan; Hamlin, Donald; Gagnon, Katherine Applied Sciences, Vol. 3, Issue 3 https://doi.org/10.3390/app3030636	journal	September 2013

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