System and process for purification of astatine-211 from target materials
Patent
·
OSTI ID:1892645
A new column-based purification system and approach are described for rapid separation and purification of the alpha-emitting therapeutic radioisotope 211At from dissolved cyclotron targets that provide highly reproducible product results with excellent 211At species distributions and high antibody labeling yields compared with prior art manual extraction results of the prior art that can be expected to enable enhanced production of purified 211At isotope products suitable for therapeutic medical applications such as treatment of cancer in human patients.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Number(s):
- 11,257,602
- Application Number:
- 15/915,283
- OSTI ID:
- 1892645
- Country of Publication:
- United States
- Language:
- English
An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211
|
journal | April 2017 |
Automated astatination of biomolecules – a stepping stone towards multicenter clinical trials
|
journal | July 2015 |
| Evaluation of Novel Wet Chemistry Separation and Purification Methods to Facilitate Automation of Astatine-211 Isolation | report | July 2016 |
Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine
|
journal | September 2013 |
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