A Solid-State Support for Separating Astatine-211 from Bismuth

Woen, David H.; Eiroa-Lledo, Cecilia; Akin, Andrew Christopher; Anderson, Nickolas H.; Bennett, Kevin T.; Birnbaum, Eva R.; Blake, Anastasia Vladimirovna; Brugh, Mark; Dalodière, Elodie Danielou; Dorman, Eric F.; Ferrier, Maryline G.; Hamlin, Donald K.; Kozimor, Stosh Anthony; Li, Yawen; Lilley, Laura Margaret; Mocko, Veronika; Thiemann, Sara Lynne; Wilbur, D. Scott; White Jr., Frankie Don

doi:10.1021/acs.inorgchem.0c00221

A Solid-State Support for Separating Astatine-211 from Bismuth

Journal Article · Fri Apr 17 00:00:00 EDT 2020 · Inorganic Chemistry

DOI:https://doi.org/10.1021/acs.inorgchem.0c00221· OSTI ID:1688758

^[1]; Eiroa-Lledo, Cecilia ^[1]; ^[1]; ^[1]; ^[1]; ^[1]; Blake, Anastasia Vladimirovna ^[1]; Brugh, Mark ^[1]; Dalodière, Elodie Danielou ^[1]; Dorman, Eric F. ^[2]; ^[2]; Hamlin, Donald K. ^[2]; ^[1]; Li, Yawen ^[2]; ^[1]; ^[1]; Thiemann, Sara Lynne ^[1]; Wilbur, D. Scott ^[2]; ^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Univ. of Washington, Seattle, WA (United States)

Increasing access to the short-lived α-emitting radionuclide astatine-211 (²¹¹At) has the potential to advance targeted α-therapeutic treatment of disease and to solve challenges facing the medical community. For example, there are numerous technical needs associated with advancing the use of ²¹¹At in targeted α-therapy, e.g., improving ²¹¹At chelates, developing more effective ²¹¹At targeting, and characterizing in vivo²¹¹At behavior. There is an insufficient understanding of astatine chemistry to support these efforts. The chemistry of astatine is one of the least developed of all elements on the periodic table, owing to its limited supply and short half-life. Increasing access to ²¹¹At could help address these issues and advance understanding of ²¹¹At chemistry in general. Here, we contribute an extraction chromatographic processing method that simplifies ²¹¹At production in terms of purification. It utilizes the commercially available Pre-Filter resin to rapidly (<1.5 h) isolate ²¹¹At from irradiated bismuth targets (Bi decontamination factors ≥876 000), in reasonable yield (68–55%) and in a form that is compatible for subsequent in vivo study. We are excited about the potential of this procedure to address ²¹¹At supply and processing/purification problems.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Nuclear Physics (NP)

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1688758

Report Number(s):: LA-UR--19-31728

Journal Information:: Inorganic Chemistry, Journal Name: Inorganic Chemistry Journal Issue: 9 Vol. 59; ISSN 0020-1669

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

References (47)

Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena Chemistry - A European Journal, Vol. 22, Issue 35 https://doi.org/10.1002/chem.201600922	journal	June 2016
Feasibility of the radioastatination of a monoclonal antibody with astatine-211 purified by wet extraction Bourgeois, Mickaël; Guerard, François; Alliot, Cyrille Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 51, Issue 11 https://doi.org/10.1002/jlcr.1543	journal	October 2008
Design and evaluation of an external high-current target for production of ²¹¹ At Gagnon, K.; Risler, R.; Pal, S. Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 55, Issue 12 https://doi.org/10.1002/jlcr.2968	journal	October 2012
Astatine Meyer, Geerd-J Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 61, Issue 3 https://doi.org/10.1002/jlcr.3573	journal	February 2018
Radioimmunotherapy with alpha-emitting nuclides McDevitt, Michael R.; Sgouros, George; Finn, Ronald D. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 25, Issue 9 https://doi.org/10.1007/s002590050306	journal	September 1998
Speciation of astatine reacted with oxidizing and reducing reagents by thin layer chromatography: formation of volatile astatine Nishinaka, I.; Hashimoto, K.; Suzuki, H. Journal of Radioanalytical and Nuclear Chemistry, Vol. 322, Issue 3 https://doi.org/10.1007/s10967-019-06900-3	journal	October 2019
Alpha-Emitters and Targeted Alpha Therapy in Oncology: from Basic Science to Clinical Investigations Makvandi, Mehran; Dupis, Edouard; Engle, Jonathan W. Targeted Oncology, Vol. 13, Issue 2 https://doi.org/10.1007/s11523-018-0550-9	journal	February 2018
Fate and Environmental Impact of Thorium Residues During Rare Earth Processing Findeiß, Matthias; Schäffer, Andreas Journal of Sustainable Metallurgy, Vol. 3, Issue 1 https://doi.org/10.1007/s40831-016-0083-3	journal	August 2016
Cyclotron isotopes and radiopharmaceuticals—XXXV astatine-211 Lambrecht, Richard M.; Mirzadeh, Saed The International Journal of Applied Radiation and Isotopes, Vol. 36, Issue 6 https://doi.org/10.1016/0020-708X(85)90207-8	journal	June 1985
Separation of astatine-211 from bismuth metal Neirinckx, R. D.; Smit, J. A. Analytica Chimica Acta, Vol. 63, Issue 1 https://doi.org/10.1016/S0003-2670(01)82189-9	journal	January 1973
Dry-distillation of astatine-211 from irradiated bismuth targets: a time-saving procedure with high recovery yields Lindegren, Sture; Bäck, Tom; Jensen, Holger J. Applied Radiation and Isotopes, Vol. 55, Issue 2 https://doi.org/10.1016/S0969-8043(01)00044-6	journal	August 2001
Characterization of At− species in simple and biological media by high performance anion exchange chromatography coupled to gamma detector Sabatié-Gogova, A.; Champion, J.; Huclier, S. Analytica Chimica Acta, Vol. 721 https://doi.org/10.1016/j.aca.2012.01.052	journal	April 2012
A new internal target system for production of 211At on the cyclotron U-120M Lebeda, O.; Jiran, R.; Ráliš, J. Applied Radiation and Isotopes, Vol. 63, Issue 1 https://doi.org/10.1016/j.apradiso.2005.02.006	journal	July 2005
Optimisation study of α-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes Groppi, F.; Bonardi, M. L.; Birattari, C. Applied Radiation and Isotopes, Vol. 63, Issue 5-6 https://doi.org/10.1016/j.apradiso.2005.05.041	journal	November 2005
An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211 O’Hara, Matthew J.; Krzysko, Anthony J.; Niver, Cynthia M. Applied Radiation and Isotopes, Vol. 122 https://doi.org/10.1016/j.apradiso.2017.02.001	journal	April 2017
211 At-labeled agents for alpha-immunotherapy: On the in vivo stability of astatine-agent bonds Ayed, Tahra; Pilmé, Julien; Tézé, David European Journal of Medicinal Chemistry, Vol. 116 https://doi.org/10.1016/j.ejmech.2016.03.082	journal	June 2016
Targeted alpha and beta radiotherapy: An overview of radiopharmaceutical and clinical aspects Lacoeuille, F.; Arlicot, N.; Faivre-Chauvet, A. Médecine Nucléaire, Vol. 42, Issue 1 https://doi.org/10.1016/j.mednuc.2017.12.002	journal	January 2018
Radiopharmaceutical chemistry of targeted radiotherapeutics, part 4: Strategies for 211At labeling at high activities and radiation doses of 211At α-particles Pozzi, Oscar R.; Zalutsky, Michael R. Nuclear Medicine and Biology, Vol. 46 https://doi.org/10.1016/j.nucmedbio.2016.11.009	journal	March 2017
Labeling of Anti-HER2 Nanobodies with Astatine-211: Optimization and the Effect of Different Coupling Reagents on Their in Vivo Behavior Dekempeneer, Yana; Bäck, Tom; Aneheim, Emma Molecular Pharmaceutics, Vol. 16, Issue 8 https://doi.org/10.1021/acs.molpharmaceut.9b00354	journal	June 2019
Synthesis and Characterization of the Actinium Aquo Ion Ferrier, Maryline G.; Stein, Benjamin W.; Batista, Enrique R. ACS Central Science, Vol. 3, Issue 3 https://doi.org/10.1021/acscentsci.6b00356	journal	February 2017
Advancing Chelation Chemistry for Actinium and Other +3 f-Elements, Am, Cm, and La Stein, Benjamin W.; Morgenstern, Amanda; Batista, Enrique R. Journal of the American Chemical Society, Vol. 141, Issue 49 https://doi.org/10.1021/jacs.9b10354	journal	November 2019
Investigation of Astatine(III) Hydrolyzed Species: Experiments and Relativistic Calculations Champion, Julie; Sabatié-Gogova, Andréa; Bassal, Fadel The Journal of Physical Chemistry A, Vol. 117, Issue 9 https://doi.org/10.1021/jp3099413	journal	February 2013
Astatine Standard Redox Potentials and Speciation in Acidic Medium Champion, J.; Alliot, C.; Renault, E. The Journal of Physical Chemistry A, Vol. 114, Issue 1 https://doi.org/10.1021/jp9077008	journal	January 2010
Astatine : The Element of Atomic Number 85 Corson, D. R.; Mackenzie, K. R.; SegrÈ, E. Nature, Vol. 159, Issue 4027 https://doi.org/10.1038/159024b0	journal	January 1947
Enigmatic astatine Wilbur, D. Scott Nature Chemistry, Vol. 5, Issue 3 https://doi.org/10.1038/nchem.1580	journal	February 2013
Spectroscopic and computational investigation of actinium coordination chemistry Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M. Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms12312	journal	August 2016
Experimental and computational evidence of halogen bonds involving astatine Guo, Ning; Maurice, Rémi; Teze, David Nature Chemistry, Vol. 10, Issue 4 https://doi.org/10.1038/s41557-018-0011-1	journal	March 2018
In vitro and preclinical targeted alpha therapy of human prostate cancer with Bi-213 labeled J591 antibody against the prostate specific membrane antigen Li, Y.; Tian, Z.; Rizvi, S. M. A. Prostate Cancer and Prostatic Diseases, Vol. 5, Issue 1 https://doi.org/10.1038/sj/pcan/4500543	journal	January 2002
The coordination chemistry of Cm ^III , Am ^III , and Ac ^III in nitrate solutions: an actinide L ₃ -edge EXAFS study Ferrier, Maryline G.; Stein, Benjamin W.; Bone, Sharon E. Chemical Science, Vol. 9, Issue 35 https://doi.org/10.1039/C8SC02270D	journal	January 2018
²¹¹ At-labeled immunoconjugate via a one-pot three-component double click strategy: practical access to α-emission cancer radiotherapeutics Fujiki, Katsumasa; Kanayama, Yousuke; Yano, Shinya Chemical Science, Vol. 10, Issue 7 https://doi.org/10.1039/C8SC04747B	journal	January 2019
Targeted α-therapy: past, present, future? Brechbiel, Martin W. Dalton Transactions, Issue 43 https://doi.org/10.1039/b704726f	journal	January 2007
Assessment of an effective quasirelativistic methodology designed to study astatine chemistry in aqueous solution Champion, Julie; Seydou, Mahamadou; Sabatié-Gogova, Andrea Physical Chemistry Chemical Physics, Vol. 13, Issue 33 https://doi.org/10.1039/c1cp20512a	journal	January 2011
Chemical Properties of Astatine. I Johnson, G. L.; Leininger, R. F.; Segrè, E. The Journal of Chemical Physics, Vol. 17, Issue 1 https://doi.org/10.1063/1.1747034	journal	January 1949
Production of [sup 211]At using the JSW BC3015 at the University of Pennsylvania Freifelder, R.; Kachur, A.; LeGeyt, B. C. 14TH INTERNATIONAL WORKSHOP ON TARGETRY AND TARGET CHEMISTRY, AIP Conference Proceedings https://doi.org/10.1063/1.4773954	conference	January 2012
Radiation Issues for Fermilab Booster Magnets Prebys, E. Proceedings of the 2005 Particle Accelerator Conference https://doi.org/10.1109/PAC.2005.1591002	conference	January 2005
Targeted deletion of T-cell clones using alpha-emitting suicide MHC tetramers Yuan, Rui Rong; Wong, Phillip; McDevitt, Michael R. Blood, Vol. 104, Issue 8 https://doi.org/10.1182/blood-2004-01-0324	journal	October 2004
Radiochemical aspects of alpha emitting radionuclides for medical application Ferrier, Maryline G.; Radchenko, Valery; Wilbur, D. Scott Radiochimica Acta, Vol. 107, Issue 9-11 https://doi.org/10.1515/ract-2019-0005	journal	September 2019
Inorganic Astatine Chemistry: Formation of Complexes of Astatine VlSSER, Gerard W. M.; Diemer, Eduard L. Radiochimica Acta, Vol. 33, Issue 2-3 https://doi.org/10.1524/ract.1983.33.23.145	journal	January 1983
Extraction of astatine-211 in diisopropylether (DIPE) Alliot, Cyrille; Chérel, Michel; Barbet, Jacques Radiochimica Acta, Vol. 97, Issue 3 https://doi.org/10.1524/ract.2009.1590	journal	January 2009
Evaluation of Novel Wet Chemistry Separation and Purification Methods to Facilitate Automation of Astatine-211 Isolation Wilbur, Daniel Scott Report https://doi.org/10.2172/1335515	report	July 2016
Alpha-Emitters for Immuno-Therapy: A Review of Recent Developments from Chemistry to Clinics Huclier-Markai, Sandrine; Alliot, Cyrille; Varmenot, Nicolas Current Topics in Medicinal Chemistry, Vol. 12, Issue 23 https://doi.org/10.2174/1568026611212230002	journal	March 2013
[211At]Astatine-Labeled Compound Stability: Issues with Released [211At]Astatide and Development of Labeling Reagents to Increase Stability Wilbur, D. Current Radiopharmaceuticalse, Vol. 1, Issue 3 https://doi.org/10.2174/1874471010801030144	journal	September 2008
Astatine-211: Production and Availability R. Zalutsky, Michael; Pruszynski, Marek Current Radiopharmaceuticalse, Vol. 4, Issue 3 https://doi.org/10.2174/1874471011104030177	journal	July 2011
Clinical Experience with -Particle Emitting 211At: Treatment of Recurrent Brain Tumor Patients with 211At-Labeled Chimeric Antitenascin Monoclonal Antibody 81C6 Zalutsky, M. R.; Reardon, D. A.; Akabani, G. Journal of Nuclear Medicine, Vol. 49, Issue 1 https://doi.org/10.2967/jnumed.107.046938	journal	December 2007
225Ac-PSMA-617 for PSMA-Targeted -Radiation Therapy of Metastatic Castration-Resistant Prostate Cancer Kratochwil, C.; Bruchertseifer, F.; Giesel, F. L. Journal of Nuclear Medicine, Vol. 57, Issue 12 https://doi.org/10.2967/jnumed.116.178673	journal	July 2016
Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine Balkin, Ethan; Hamlin, Donald; Gagnon, Katherine Applied Sciences, Vol. 3, Issue 3 https://doi.org/10.3390/app3030636	journal	September 2013
Folate Receptor Targeted Alpha-Therapy Using Terbium-149 Müller, Cristina; Reber, Josefine; Haller, Stephanie Pharmaceuticals, Vol. 7, Issue 3 https://doi.org/10.3390/ph7030353	journal	March 2014

Similar Records

Production of Astatine-211 for U.S. Investigators

Technical Report · Tue Dec 11 23:00:00 EST 2012 · OSTI ID:1124492

Production of Astatine-211 at the Duke University Medical Center for its regional distribution

Technical Report · Thu Dec 31 23:00:00 EST 2015 · OSTI ID:1233560

Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets

Journal Article · Sun Dec 29 23:00:00 EST 2019 · Scientific Reports · OSTI ID:1619685

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
bismuth
elements
half-life
irradiation
organic polymers

A Solid-State Support for Separating Astatine-211 from Bismuth

Citation Formats

References (47)

Similar Records

Related Subjects