Evaluation of two extraction chromatography resins for scandium and titanium separation for medical isotope production

McLain, Derek R.; Brossard, Thomas W.; De Kruijff, Robin; Kankanamalage, Pavithra A.; Rotsch, David A.

doi:10.1007/s10967-023-08783-x

Evaluation of two extraction chromatography resins for scandium and titanium separation for medical isotope production

Journal Article · Mon Feb 13 00:00:00 EST 2023 · Journal of Radioanalytical and Nuclear Chemistry

DOI:https://doi.org/10.1007/s10967-023-08783-x· OSTI ID:1991244

^[1]; Brossard, Thomas W. ^[1]; De Kruijff, Robin ^[2]; Kankanamalage, Pavithra A. ^[1]; Rotsch, David A. ^[1]

Argonne National Laboratory (ANL), Argonne, IL (United States)
Delft University of Technology (Netherlands)

Scandium-47 (⁴⁷Sc) can be used in nuclear medicine as a therapeutic-diagnostic, or "theragnostic," radioactive medical isotope for cancer detection and treatment. The ⁴⁷Sc isotope can be produced through the photonuclear reaction ⁴⁸Ti(γ,p)⁴⁷Sc by irradiating enriched ⁴⁸Ti target material. The enriched target material necessary for production is costly; ⁴⁸TiO₂ costs ~ $$\$$$$1550/g, and targets can be > 50 g ($$\$$$$77,500) to produce medically relevant amounts of ⁴⁷Sc. In order to keep costs low, a highly efficient separation of scandium from bulk titanium is desired, along with efficient methods for recycling the target material. Here this research is focused on evaluating efficient methods for the separation of scandium from bulk quantities of titanium using commercially available diglycolamide-based and hydroxamate-based extraction chromatography resins (DGA resin and ZR resin, respectively). The sorption of ⁴⁷Sc and Ti on these resins were investigated at varying concentrations of HNO₃, HCl, H₂SO₄, and HF to explore how they might be used in a large-scale production/processing setting.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1991244

Journal Information:: Journal of Radioanalytical and Nuclear Chemistry, Journal Name: Journal of Radioanalytical and Nuclear Chemistry Journal Issue: 3 Vol. 332; ISSN 0236-5731

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

References (41)

Separation of carrier-free47Sc from titanium targets Pietrelli, L.; Mausner, L. F.; Kolsky, K. L. Journal of Radioanalytical and Nuclear Chemistry Articles, Vol. 157, Issue 2 https://doi.org/10.1007/BF02047448	journal	March 1992
Separation of no-carrier-added radioactive scandium from neutron irradiated titanium Bokhari, Tanveer Hussain; Mushtaq, A.; Khan, Islam Ullah Journal of Radioanalytical and Nuclear Chemistry, Vol. 283, Issue 2 https://doi.org/10.1007/s10967-009-0370-6	journal	December 2009
Accelerator-based photoproduction of promising beta-emitters 67Cu and 47Sc Starovoitova, Valeriia N.; Cole, Philip L.; Grimm, Terry L. Journal of Radioanalytical and Nuclear Chemistry, Vol. 305, Issue 1 https://doi.org/10.1007/s10967-015-4039-z	journal	March 2015
A new method for separating first row transition metals and actinides from synthetic melt glass Roman, Audrey R.; Bond, Evelyn M. Journal of Radioanalytical and Nuclear Chemistry, Vol. 307, Issue 3 https://doi.org/10.1007/s10967-016-4695-7	journal	January 2016
47Sc production development by cyclotron irradiation of 48Ca Misiak, R.; Walczak, R.; Wąs, B. Journal of Radioanalytical and Nuclear Chemistry, Vol. 313, Issue 2 https://doi.org/10.1007/s10967-017-5321-z	journal	June 2017
Using Sr Resin with mixed acid matrices McLain, Derek R.; Liu, Christine; Sudowe, Ralf Journal of Radioanalytical and Nuclear Chemistry, Vol. 316, Issue 2 https://doi.org/10.1007/s10967-018-5778-4	journal	March 2018
New developments in the production of theranostic pairs of radionuclides Qaim, Syed M.; Scholten, Bernhard; Neumaier, Bernd Journal of Radioanalytical and Nuclear Chemistry, Vol. 318, Issue 3 https://doi.org/10.1007/s10967-018-6238-x	journal	October 2018
Theranostic radionuclides: recent advances in production methodologies Qaim, Syed M. Journal of Radioanalytical and Nuclear Chemistry, Vol. 322, Issue 3 https://doi.org/10.1007/s10967-019-06797-y	journal	September 2019
Production of 47Sc with natural vanadium targets: results of the PASTA project Pupillo, Gaia; Mou, Liliana; Boschi, Alessandra Journal of Radioanalytical and Nuclear Chemistry, Vol. 322, Issue 3 https://doi.org/10.1007/s10967-019-06844-8	journal	October 2019
Separation and preconcentration of uranium from acidic media by extraction chromatography Horwitz, E. Philip; Dietz, Mark L.; Chiarizia, Renato Analytica Chimica Acta, Vol. 266, Issue 1 https://doi.org/10.1016/0003-2670(92)85276-C	journal	August 1992
Preparation of carrier-free 47Sc by the 48Ti (γ,p) reaction Yagi, Masuo; Kondo, Kenjiro The International Journal of Applied Radiation and Isotopes, Vol. 28, Issue 5 https://doi.org/10.1016/0020-708X(77)90178-8	journal	May 1977
Radionuclide development at BNL for nuclear medicine therapy Mausner, L. F.; Kolsky, K. L.; Joshi, V. Applied Radiation and Isotopes, Vol. 49, Issue 4 https://doi.org/10.1016/S0969-8043(97)00040-7	journal	April 1998
Radiochemical purification of no-carrier-added scandium-47 for radioimmunotherapy Kolsky, K. L.; Joshi, V.; Mausner, L. F. Applied Radiation and Isotopes, Vol. 49, Issue 12 https://doi.org/10.1016/S0969-8043(98)00016-5	journal	December 1998
Sc-47 production from titanium targets using electron linacs Mamtimin, Mayir; Harmon, Frank; Starovoitova, Valeriia N. Applied Radiation and Isotopes, Vol. 102 https://doi.org/10.1016/j.apradiso.2015.04.012	journal	August 2015
Production of scandium-43 and -47 from a powdery calcium oxide target via the nat/44Ca(α,x)-channel Minegishi, Katsuyuki; Nagatsu, Kotaro; Fukada, Masami Applied Radiation and Isotopes, Vol. 116 https://doi.org/10.1016/j.apradiso.2016.07.017	journal	October 2016
Production and purification of Scandium-47: A potential radioisotope for cancer theranostics Deilami-nezhad, Leila; Moghaddam-Banaem, Leila; Sadeghi, Mahdi Applied Radiation and Isotopes, Vol. 118 https://doi.org/10.1016/j.apradiso.2016.09.004	journal	December 2016
Electron linear accelerator production and purification of scandium-47 from titanium dioxide targets Rotsch, David A.; Brown, M. Alex; Nolen, Jerry A. Applied Radiation and Isotopes, Vol. 131 https://doi.org/10.1016/j.apradiso.2017.11.007	journal	January 2018
Production of Sc medical radioisotopes with proton and deuteron beams Sitarz, Mateusz; Szkliniarz, Katarzyna; Jastrzębski, Jerzy Applied Radiation and Isotopes, Vol. 142 https://doi.org/10.1016/j.apradiso.2018.09.025	journal	December 2018
Comparison of separation methods for 47Ca/47Sc radionuclide generator Pawlak, Dariusz; Wojdowska, Wioletta; Parus, Leon Jozef Applied Radiation and Isotopes, Vol. 151 https://doi.org/10.1016/j.apradiso.2019.05.020	journal	September 2019
Optimized methods for production and purification of Titanium-45 Chaple, Ivis F.; Thiele, Kathryn; Thaggard, Grace Applied Radiation and Isotopes, Vol. 166 https://doi.org/10.1016/j.apradiso.2020.109398	journal	December 2020
High purity 47Sc production using high-energy photons and natural vanadium targets Snow, Mathew S.; Foley, Ari; Ward, Jessica L. Applied Radiation and Isotopes, Vol. 178 https://doi.org/10.1016/j.apradiso.2021.109934	journal	December 2021
Evaluation of hydroxamate-based resins towards a more clinically viable 44Ti/44Sc radionuclide generator Gajecki, Leah; Marino, Celine M.; Cutler, Cathy S. Applied Radiation and Isotopes, Vol. 192 https://doi.org/10.1016/j.apradiso.2022.110588	journal	February 2023
Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/44Sc generator system Radchenko, V.; Meyer, C. A. L.; Engle, J. W. Journal of Chromatography A, Vol. 1477 https://doi.org/10.1016/j.chroma.2016.11.047	journal	December 2016
Nuclear Data Sheets for A = 47 Burrows, T. W. Nuclear Data Sheets, Vol. 108, Issue 5 https://doi.org/10.1016/j.nds.2007.04.002	journal	May 2007
Standardized methods for the production of high specific-activity zirconium-89 Holland, Jason P.; Sheh, Yiauchung; Lewis, Jason S. Nuclear Medicine and Biology, Vol. 36, Issue 7 https://doi.org/10.1016/j.nucmedbio.2009.05.007	journal	October 2009
Cyclotron production of high purity 44m,44 Sc with deuterons from 44 CaCO 3 targets Alliot, C.; Kerdjoudj, R.; Michel, N. Nuclear Medicine and Biology, Vol. 42, Issue 6 https://doi.org/10.1016/j.nucmedbio.2015.03.002	journal	June 2015
Proton-induced production and radiochemical isolation of 44Ti from scandium metal targets for 44Ti/44Sc generator development Radchenko, Valery; Engle, Jonathan W.; Medvedev, Dmitri G. Nuclear Medicine and Biology, Vol. 50 https://doi.org/10.1016/j.nucmedbio.2017.03.006	journal	July 2017
Distribution coefficients of 60 elements on TODGA resin: Application to Ca, Lu, Hf, U and Th isotope geochemistry Pourmand, Ali; Dauphas, Nicolas Talanta, Vol. 81, Issue 3 https://doi.org/10.1016/j.talanta.2010.01.008	journal	May 2010
An ICP-OES Method with 0.2 Expanded Uncertainties for the Characterization of LiAlO ₂ Salit, Marc L.; Vocke, Robert D.; Kelly, W. Robert Analytical Chemistry, Vol. 72, Issue 15 https://doi.org/10.1021/ac0000877	journal	August 2000
Single-Element Solution Comparisons with a High-Performance Inductively Coupled Plasma Optical Emission Spectrometric Method Salit, Marc L.; Turk, Gregory C.; Lindstrom, Abigail P. Analytical Chemistry, Vol. 73, Issue 20 https://doi.org/10.1021/ac0155097	journal	October 2001
A Drift Correction Procedure Salit, Marc L.; Turk, Gregory C. Analytical Chemistry, Vol. 70, Issue 15 https://doi.org/10.1021/ac980095b	journal	August 1998
Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers Wahsner, Jessica; Gale, Eric M.; Rodríguez-Rodríguez, Aurora Chemical Reviews, Vol. 119, Issue 2 https://doi.org/10.1021/acs.chemrev.8b00363	journal	September 2018
Production, Collection, and Purification of ⁴⁷ Ca for the Generation of ⁴⁷ Sc through Isotope Harvesting at the National Superconducting Cyclotron Laboratory Abel, E. Paige; Domnanich, Katharina; Clause, Hannah K. ACS Omega, Vol. 5, Issue 43 https://doi.org/10.1021/acsomega.0c03020	journal	October 2020
Matching chelators to radiometals for radiopharmaceuticals Price, Eric W.; Orvig, Chris Chem. Soc. Rev., Vol. 43, Issue 1 https://doi.org/10.1039/C3CS60304K	journal	January 2014
PSMA-Targeted Radiopharmaceuticals for Imaging and Therapy Wester, Hans-Jürgen; Schottelius, Margret Seminars in Nuclear Medicine, Vol. 49, Issue 4 https://doi.org/10.1053/j.semnuclmed.2019.02.008	journal	July 2019
Novel Extraction of Chromatographic Resins Based on Tetraalkyldiglycolamides: Characterization and Potential Applications Horwitz, E. P.; McAlister, D. R.; Bond, A. H. Solvent Extraction and Ion Exchange, Vol. 23, Issue 3 https://doi.org/10.1081/SEI-200049898	journal	May 2005
44Sc-PSMA-617 for radiotheragnostics in tandem with 177Lu-PSMA-617—preclinical investigations in comparison with 68Ga-PSMA-11 and 68Ga-PSMA-617 Umbricht, Christoph A.; Benešová, Martina; Schmid, Raffaella M. EJNMMI Research, Vol. 7, Issue 1 https://doi.org/10.1186/s13550-017-0257-4	journal	January 2017
Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47Sc Loveless, C. Shaun; Radford, Lauren L.; Ferran, Samuel J. EJNMMI Research, Vol. 9, Issue 1 https://doi.org/10.1186/s13550-019-0515-8	journal	May 2019
Paving the way to personalized medicine: production of some theragnostic radionuclides at Brookhaven National Laboratory Srivastava, Suresh C. Radiochimica Acta, Vol. 99, Issue 10 https://doi.org/10.1524/ract.2011.1882	journal	October 2011
Accelerator Production of Scandium Radioisotopes: Sc-43, Sc-44, and Sc-47 Chernysheva, Margarita; Loveless, Shaun C.; Brossard, Tom Current Radiopharmaceuticals, Vol. 14, Issue 4 https://doi.org/10.2174/1874471014999210112205535	journal	November 2021
Promising Prospects for 44Sc-/47Sc-Based Theragnostics: Application of 47Sc for Radionuclide Tumor Therapy in Mice Muller, C.; Bunka, M.; Haller, S. Journal of Nuclear Medicine, Vol. 55, Issue 10 https://doi.org/10.2967/jnumed.114.141614	journal	July 2014

Figures / Tables (9)

Similar Records

Electron linear accelerator production and purification of scandium-47 from titanium dioxide targets

Journal Article · Sun Nov 05 19:00:00 EST 2017 · Applied Radiation and Isotopes · OSTI ID:1421964

Production of Radioisotopes of Scandium for Imaging and Therapy (Final Report)

Technical Report · Mon Apr 03 00:00:00 EDT 2023 · OSTI ID:1967920

⁴⁸Ca(p,pn)⁴⁷Ca linac production for the preparation of a ⁴⁷Ca/⁴⁷Sc generator

Journal Article · Sun Nov 02 19:00:00 EST 2025 · Applied Radiation and Isotopes · OSTI ID:3009100

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
Sc-47
diglycolamide resin
extraction chromatography
hydroxamate resin
medical isotopes
theranostic isotope

Evaluation of two extraction chromatography resins for scandium and titanium separation for medical isotope production

Citation Formats

References (41)

Figures / Tables (9)

Similar Records

Related Subjects