Electron linear accelerator production and purification of scandium-47 from titanium dioxide targets

Rotsch, David A.; Brown, M. Alex; Nolen, Jerry A.; Brossard, Thomas; Henning, Walter F.; Chemerisov, Sergey D.; Gromov, Roman G.; Greene, John

doi:10.1016/j.apradiso.2017.11.007

Electron linear accelerator production and purification of scandium-47 from titanium dioxide targets

Journal Article · Mon Nov 06 00:00:00 EST 2017 · Applied Radiation and Isotopes

DOI:https://doi.org/10.1016/j.apradiso.2017.11.007· OSTI ID:1421964

Rotsch, David A. ^[1]; Brown, M. Alex ^[1]; Nolen, Jerry A. ^[1]; Brossard, Thomas ^[1]; Henning, Walter F. ^[1]; Chemerisov, Sergey D. ^[1]; Gromov, Roman G. ^[1]; Greene, John ^[1]

Argonne National Lab. (ANL), Argonne, IL (United States)

Here, the photonuclear production of no-carrier-added (NCA) ⁴⁷Sc from solid ^NatTiO₂ and the subsequent chemical processing and purification have been developed. Scandium-47 was produced by the ⁴⁸Ti(γ,p)⁴⁷Sc reaction with Bremsstrahlung photons produced from the braking of electrons in a high-Z (W or Ta) convertor. Production yields were simulated with the PHITS code (Particle and Heavy Ion Transport-code System) and compared to experimental results. Irradiated TiO₂ targets were dissolved in fuming H₂SO₄ in the presence of Na₂SO₄ and ⁴⁷Sc was purified using the commercially available Eichrom DGA resin. Typical ⁴⁷Sc recovery yields were >90% with excellent specific activity for small batches (<185 MBq batches).

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Organization:: Argonne National Laboratory; U.S. Department of Energy (Office not specified); USDOE

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1421964

Alternate ID(s):: OSTI ID: 1549051

Journal Information:: Applied Radiation and Isotopes, Journal Name: Applied Radiation and Isotopes Journal Issue: C Vol. 131; ISSN 0969-8043

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Scandium and terbium radionuclides for radiotheranostics: current state of development towards clinical application Müller, Cristina; Domnanich, Katharina A.; Umbricht, Christoph A. The British Journal of Radiology, Vol. 91, Issue 1091 https://doi.org/10.1259/bjr.20180074	journal	November 2018
New developments in the production of theranostic pairs of radionuclides Qaim, Syed M.; Scholten, Bernhard; Neumaier, Bernd Journal of Radioanalytical and Nuclear Chemistry, Vol. 318, Issue 3 https://doi.org/10.1007/s10967-018-6238-x	journal	October 2018
Theranostic radionuclides: recent advances in production methodologies Qaim, Syed M. Journal of Radioanalytical and Nuclear Chemistry, Vol. 322, Issue 3 https://doi.org/10.1007/s10967-019-06797-y	journal	September 2019
Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47Sc Loveless, C. Shaun; Radford, Lauren L.; Ferran, Samuel J. EJNMMI Research, Vol. 9, Issue 1 https://doi.org/10.1186/s13550-019-0515-8	journal	May 2019

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