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Title: Pharmacologic perturbation as a potential tool to increase the sensitivity of FDG-PET in the evaluation of brain tumors

Abstract

The usefulness of F-18 FDG PET in the study of brain tumors is limited by the high baseline cortical uptake which decreases the contrast of the tumor. Two alternatives to increase the tumor/background contrast have been reported: barbiturate-induced coma and postprandial state. This project evaluates the effects of sedation with diazepam or of oral glucose intake on the brain tumor/background contrast during F-18 FDG PET studies.

Authors:
; ;  [1]
  1. Univ. of Texas M.D. Anderson Cancer Center, Houston, TX (United States) [and others
Publication Date:
OSTI Identifier:
198087
Report Number(s):
CONF-940605-
Journal ID: JNMEAQ; ISSN 0161-5505; TRN: 95:007029-0239
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Nuclear Medicine; Journal Volume: 35; Journal Issue: Suppl.5; Conference: 41. annual meeting of the Society of Nuclear Medicine, Orlando, FL (United States), 5-8 Jun 1994; Other Information: PBD: May 1994
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; BRAIN; NEOPLASMS; FLUORODEOXYGLUCOSE; UPTAKE; POSITRON COMPUTED TOMOGRAPHY; SENSITIVITY; GLIOMAS; IMAGES; PATIENTS; FLUORINE 18; LABELLED COMPOUNDS

Citation Formats

Wong, F.C.L., Kim, E.E., and Yung, W.K.A.. Pharmacologic perturbation as a potential tool to increase the sensitivity of FDG-PET in the evaluation of brain tumors. United States: N. p., 1994. Web.
Wong, F.C.L., Kim, E.E., & Yung, W.K.A.. Pharmacologic perturbation as a potential tool to increase the sensitivity of FDG-PET in the evaluation of brain tumors. United States.
Wong, F.C.L., Kim, E.E., and Yung, W.K.A.. 1994. "Pharmacologic perturbation as a potential tool to increase the sensitivity of FDG-PET in the evaluation of brain tumors". United States. doi:.
@article{osti_198087,
title = {Pharmacologic perturbation as a potential tool to increase the sensitivity of FDG-PET in the evaluation of brain tumors},
author = {Wong, F.C.L. and Kim, E.E. and Yung, W.K.A.},
abstractNote = {The usefulness of F-18 FDG PET in the study of brain tumors is limited by the high baseline cortical uptake which decreases the contrast of the tumor. Two alternatives to increase the tumor/background contrast have been reported: barbiturate-induced coma and postprandial state. This project evaluates the effects of sedation with diazepam or of oral glucose intake on the brain tumor/background contrast during F-18 FDG PET studies.},
doi = {},
journal = {Journal of Nuclear Medicine},
number = Suppl.5,
volume = 35,
place = {United States},
year = 1994,
month = 5
}