Effects of hyperglycemia on FDG-PET in patients with brain tumors

Journal Article · Sun May 01 04:00:00 EDT 1994 · Journal of Nuclear Medicine

OSTI ID:197917

Ishizu, K; Nishizawa, S; Yonekura, Y ^[1]

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1. Kyoto Univ. (Japan); and others

In order to evaluate the effects of hyperglycemia on fluorodeoxyglucose (FDG) uptake in normal brain and brain tumors, we performed glucose loading during FDG-PET studies in 8 patients with brain tumors (7 gliomas and 1 metastatic tumor). Two FDG-PET studies were performed in all cases within a week; in control state and with glucose loading by intravenous infusion of 10% glucose solution. Serial arterial blood sampling was performed in all cases to obtain fractional uptake of FDG normalized by plasma integral of radioactivity (FU). On the static FDG images acquired from 40 to 60 minutes after FDG injection, regions of interests were placed on the representative area of the tumor and the normal brain. In all cases, the tumor was depicted more clearly with glucose loading than in control state. Glucose loading decreased FU in cerebral cortex (53.5{plus_minus}15.3%) nearly in inverse proportion to plasma glucose level, while the tumor showed a less decrease (42.5{plus_minus}16.5%), resulting in the increased tumor to cortex ratio by 25.7{plus_minus}6.0%. Cerebellum, white matter and the edematous area also showed decreased FU in glucose loading PET (53.7{plus_minus}14.0%, 49.3{plus_minus}10.4% and 34.9{plus_minus}9.6%, respectively). The results demonstrated the different effects of hyperglycemia on normal brain and tumor, and glucose loading may be a valuable adjunct to FDG-PET study to enhance detection of recurrent or residual brain tumors.

• OSTI ID: 197917
• Report Number(s): CONF-940605--
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN 0161-5505; ISSN JNMEAQ
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BRAIN
FLUORODEOXYGLUCOSE
HYPERGLYCEMIA
IMAGES
INJECTION
NEOPLASMS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
UPTAKE