Effects of hyperglycemia on FDG-PET in patients with brain tumors
- Kyoto Univ. (Japan); and others
In order to evaluate the effects of hyperglycemia on fluorodeoxyglucose (FDG) uptake in normal brain and brain tumors, we performed glucose loading during FDG-PET studies in 8 patients with brain tumors (7 gliomas and 1 metastatic tumor). Two FDG-PET studies were performed in all cases within a week; in control state and with glucose loading by intravenous infusion of 10% glucose solution. Serial arterial blood sampling was performed in all cases to obtain fractional uptake of FDG normalized by plasma integral of radioactivity (FU). On the static FDG images acquired from 40 to 60 minutes after FDG injection, regions of interests were placed on the representative area of the tumor and the normal brain. In all cases, the tumor was depicted more clearly with glucose loading than in control state. Glucose loading decreased FU in cerebral cortex (53.5{plus_minus}15.3%) nearly in inverse proportion to plasma glucose level, while the tumor showed a less decrease (42.5{plus_minus}16.5%), resulting in the increased tumor to cortex ratio by 25.7{plus_minus}6.0%. Cerebellum, white matter and the edematous area also showed decreased FU in glucose loading PET (53.7{plus_minus}14.0%, 49.3{plus_minus}10.4% and 34.9{plus_minus}9.6%, respectively). The results demonstrated the different effects of hyperglycemia on normal brain and tumor, and glucose loading may be a valuable adjunct to FDG-PET study to enhance detection of recurrent or residual brain tumors.
- OSTI ID:
- 197917
- Report Number(s):
- CONF-940605-; ISSN 0161-5505; TRN: 95:007029-0052
- Journal Information:
- Journal of Nuclear Medicine, Vol. 35, Issue Suppl.5; Conference: 41. annual meeting of the Society of Nuclear Medicine, Orlando, FL (United States), 5-8 Jun 1994; Other Information: PBD: May 1994
- Country of Publication:
- United States
- Language:
- English
Similar Records
In vitro study of PET tumor tracers at normal and elevated media glucose levels
Correlation of {sup 18}F-FDG Avid Volumes on Pre–Radiation Therapy and Post–Radiation Therapy FDG PET Scans in Recurrent Lung Cancer