Reversal of brain metabolic abnormalities following treatment of AIDS dementia complex with 3'-azido-2',3'-dideoxythymidine (AZT, zidovudine): a PET-FDG study

Journal Article · Mon May 01 04:00:00 EDT 1989 · J. Nucl. Med.; (United States)

OSTI ID:6028988

Brunetti, A; Berg, G; Di Chiro, G; Cohen, R M; Yarchoan, R; Pizzo, P A; Broder, S; Eddy, J; Fulham, M J; Finn, R D

Brain glucose metabolism was evaluated in four patients with acquired immunodeficiency syndrome (AIDS) dementia complex using (/sup 18/F)fluorodeoxyglucose (FDG) and positron emission tomography (PET) scans at the beginning of therapy with 3'-azido-2',3'-dideoxythymidine (AZT, zidovudine), and later in the course of therapy. In two patients, baseline, large focal cortical abnormalities of glucose utilization were reversed during the course of therapy. In the other two patients, the initial PET study did not reveal pronounced focal alterations, while the post-treatment scans showed markedly increased cortical glucose metabolism. The improved cortical glucose utilization was accompanied in all patients by immunologic and neurologic improvement. PET-FDG studies can detect cortical metabolic abnormalities associated with AIDS dementia complex, and may be used to monitor the metabolic improvement in response to AZT treatment.

• Research Organization: NINCDS, Bethesda, MD (USA)
• OSTI ID: 6028988
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 30:5; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AIDS
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CHEMOTHERAPY
COLOR
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEMIC DISEASES
HEXOSES
HOURS LIVING RADIOISOTOPES
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
ISOTOPES
LIGHT NUCLEI
METABOLIC DISEASES
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
OPTICAL PROPERTIES
ORGANIC COMPOUNDS
ORGANOLEPTIC PROPERTIES
ORGANS
PATIENTS
PHYSICAL PROPERTIES
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SACCHARIDES
THERAPY
TOMOGRAPHY
VIRAL DISEASES