The Missing Pieces: The Role of Secretion Systems in Campylobacter jejuni Virulence

Gabbert, Amber D.; Mydosh, Jennifer L.; Talukdar, Prabhat K.; Gloss, Lisa M.; McDermott, Jason E.; Cooper, Kerry K.; Clair, Geremy C.; Konkel, Michael E.

doi:10.3390/biom13010135

The Missing Pieces: The Role of Secretion Systems in Campylobacter jejuni Virulence

Journal Article · Mon Jan 09 00:00:00 EST 2023 · Biomolecules

DOI:https://doi.org/10.3390/biom13010135· OSTI ID:1924525

Gabbert, Amber D. ^[1]; Mydosh, Jennifer L. ^[2]; ^[1]; Gloss, Lisa M. ^[1]; ^[3]; ^[2]; ^[3]; ^[1]

Washington State Univ., Pullman, WA (United States)
Univ. of Arizona, Tucson, AZ (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Campylobacter jejuni is likely the most common bacterial cause of gastroenteritis worldwide, responsible for millions of cases of inflammatory diarrhea characterized by severe abdominal cramps and blood in the stool. Further, C. jejuni infections are associated with post-infection sequelae in developed countries and malnutrition and growth-stunting in low- and middle-income countries. Despite the increasing prevalence of the disease, campylobacteriosis, and the recognition that this pathogen is a serious health threat, our understanding of C. jejuni pathogenesis remains incomplete. In this review, we focus on the Campylobacter secretion systems proposed to contribute to host-cell interactions and survival in the host. Moreover, we have applied a genomics approach to defining the structural and mechanistic features of C. jejuni type III, IV, and VI secretion systems. Special attention is focused on the flagellar type III secretion system and the prediction of putative effectors, given that the proteins exported via this system are essential for host cell invasion and the inflammatory response. We conclude that C. jejuni does not possess a type IV secretion system and relies on the type III and type VI secretion systems to establish a niche and potentiate disease.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1924525

Report Number(s):: PNNL-SA-181015

Journal Information:: Biomolecules, Journal Name: Biomolecules Journal Issue: 1 Vol. 13; ISSN 2218-273X

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
bacteria-host cell interactions
effectors
secretion
type III secretion system
type IV secretion system
type VI secretion system

The Missing Pieces: The Role of Secretion Systems in Campylobacter jejuni Virulence

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