Protein-Nanoparticle Interactions Govern the Interfacial Behavior of Polymeric Nanogels: Study of Protein Corona Formation at the Air/Water Interface

Traldi, Federico; Liu, Pengfei; Albino, Inês; Ferreira, Lino; Zarbakhsh, Ali; Resmini, Marina

doi:10.3390/ijms24032810

Protein-Nanoparticle Interactions Govern the Interfacial Behavior of Polymeric Nanogels: Study of Protein Corona Formation at the Air/Water Interface

Journal Article · Tue Jan 31 23:00:00 EST 2023 · International Journal of Molecular Sciences (Online)

DOI:https://doi.org/10.3390/ijms24032810· OSTI ID:1923095

; Liu, Pengfei; ; Ferreira, Lino; ;

Biomedical applications of nanoparticles require a fundamental understanding of their interactions and behavior with biological interfaces. Protein corona formation can alter the morphology and properties of nanomaterials, and knowledge of the interfacial behavior of the complexes, using in situ analytical techniques, will impact the development of nanocarriers to maximize uptake and permeability at cellular interfaces. In this study we evaluate the interactions of acrylamide-based nanogels, with neutral, positive, and negative charges, with serum-abundant proteins albumin, fibrinogen, and immunoglobulin G. The formation of a protein corona complex between positively charged nanoparticles and albumin is characterized by dynamic light scattering, circular dichroism, and surface tensiometry; we use neutron reflectometry to resolve the complex structure at the air/water interface and demonstrate the effect of increased protein concentration on the interface. Surface tensiometry data suggest that the structure of the proteins can impact the interfacial properties of the complex formed. These results contribute to the understanding of the factors that influence the bio-nano interface, which will help to design nanomaterials with improved properties for applications in drug delivery.

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Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Transportation Office. Fuel Cell Technologies Office

OSTI ID:: 1923095

Journal Information:: International Journal of Molecular Sciences (Online), Journal Name: International Journal of Molecular Sciences (Online) Journal Issue: 3 Vol. 24; ISSN IJMCFK; ISSN 1422-0067

Publisher:: MDPI AGCopyright Statement

Country of Publication:: Switzerland

Language:: English

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Qualitative and Quantitative Detection of PrPSc Based on the Controlled Release Property of Magnetic Microspheres Using Surface Plasmon Resonance (SPR) Lou, Zhichao; Han, He; Mao, Dun Nanomaterials, Vol. 8, Issue 2 https://doi.org/10.3390/nano8020107	journal	February 2018
Covalently Crosslinked Nanogels: An NMR Study of the Effect of Monomer Reactivity on Composition and Structure Liu, Pengfei; Pearce, Charles M.; Anastasiadi, Rozalia-Maria Polymers, Vol. 11, Issue 2 https://doi.org/10.3390/polym11020353	journal	February 2019
Biomechanical sensing of in vivo magnetic nanoparticle hyperthermia-treated melanoma using magnetomotive optical coherence elastography Huang, Pin-Chieh; Chaney, Eric J.; Aksamitiene, Edita Theranostics, Vol. 11, Issue 12 https://doi.org/10.7150/thno.55333	journal	January 2021

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