Increased Attack Rates and Decreased Incubation Periods in Raccoons with Chronic Wasting Disease Passaged through Meadow Voles

Moore, S. Jo; Carlson, Christina M.; Schneider, Jay R.; Johnson, Christopher J.; Greenlee, Justin J.

doi:10.3201/eid2804.210271

Increased Attack Rates and Decreased Incubation Periods in Raccoons with Chronic Wasting Disease Passaged through Meadow Voles

Journal Article · Fri Apr 01 00:00:00 EDT 2022 · Emerging Infectious Diseases

DOI:https://doi.org/10.3201/eid2804.210271· OSTI ID:1905056

Moore, S. Jo ^[1]; Carlson, Christina M. ^[2]; Schneider, Jay R. ^[2]; Johnson, Christopher J. ^[2]; Greenlee, Justin J. ^[3]

US Dept. of Agriculture (USDA), Ames, IA (United States); OSTI
US Geological Survey, Madison, WI (United States)
US Dept. of Agriculture (USDA), Ames, IA (United States)

Chronic wasting disease (CWD) is a naturally-occurring neurodegenerative disease of cervids. Raccoons (Procyon lotor) and meadow voles (Microtus pennsylvanicus) have previously been shown to be susceptible to the CWD agent. To investigate the potential for transmission of the agent of CWD from white-tailed deer to voles and subsequently to raccoons, we intracranially inoculated raccoons with brain homogenate from a CWD-affected white-tailed deer (CWD^Wtd) or derivatives of this isolate after it had been passaged through voles 1 or 5 times. We found that passage of the CWDWtd isolate through voles led to a change in the biologic behavior of the CWD agent, including increased attack rates and decreased incubation periods in raccoons. A better understanding of the dynamics of cross-species transmission of CWD prions can provide insights into how these infectious proteins evolve in new hosts.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: US Department of Agriculture; USDOE Office of Science (SC)

Grant/Contract Number:: SC0014664

OSTI ID:: 1905056

Journal Information:: Emerging Infectious Diseases, Journal Name: Emerging Infectious Diseases Journal Issue: 4 Vol. 28; ISSN 1080-6040

Publisher:: Centers for Disease Control and Prevention (CDC)Copyright Statement

Country of Publication:: United States

Language:: English

References (36)

The pathology of infection with Schistosomatium douthitti in the laboratory mouse and the meadow vole, Microtus pennsylvanicus Zajac, A. M.; Williams, J. F. Journal of Comparative Pathology, Vol. 91, Issue 1 https://doi.org/10.1016/0021-9975(81)90039-6	journal	January 1981
Grass Plants Bind, Retain, Uptake, and Transport Infectious Prions Pritzkow, Sandra; Morales, Rodrigo; Moda, Fabio Cell Reports, Vol. 11, Issue 8 https://doi.org/10.1016/j.celrep.2015.04.036	journal	May 2015
Asymptomatic deer excrete infectious prions in faeces Tamgüney, Gültekin; Miller, Michael W.; Wolfe, Lisa L. Nature, Vol. 461, Issue 7263 https://doi.org/10.1038/nature08289	journal	September 2009
Chronic wasting disease (CWD) prion strains evolve via adaptive diversification of conformers in hosts expressing prion protein polymorphisms Duque Velásquez, Camilo; Kim, Chae; Haldiman, Tracy Journal of Biological Chemistry, Vol. 295, Issue 15 https://doi.org/10.1074/jbc.RA120.012546	journal	April 2020
Evidence for distinct chronic wasting disease (CWD) strains in experimental CWD in ferrets Perrott, Matthew R.; Sigurdson, Christina J.; Mason, Gary L. Journal of General Virology, Vol. 93, Issue 1 https://doi.org/10.1099/vir.0.035006-0	journal	January 2012
Polymorphisms in the prion precursor functional gene but not the pseudogene are associated with susceptibility to chronic wasting disease in white-tailed deer O'Rourke, Katherine I.; Spraker, Terry R.; Hamburg, Linda K. Journal of General Virology, Vol. 85, Issue 5 https://doi.org/10.1099/vir.0.79785-0	journal	May 2004
Prion protein polymorphisms in white-tailed deer influence susceptibility to chronic wasting disease Johnson, Chad; Johnson, Jody; Vanderloo, Joshua P. Journal of General Virology, Vol. 87, Issue 7 https://doi.org/10.1099/vir.0.81615-0	journal	July 2006
Patterns of PrPCWD accumulation during the course of chronic wasting disease infection in orally inoculated mule deer (Odocoileus hemionus) Fox, Karen A.; Jewell, Jean E.; Williams, Elizabeth S. Journal of General Virology, Vol. 87, Issue 11 https://doi.org/10.1099/vir.0.81999-0	journal	November 2006
Generation of novel neuroinvasive prions following intravenous challenge Aguilar-Calvo, Patricia; Bett, Cyrus; Sevillano, Alejandro M. Brain Pathology, Vol. 28, Issue 6 https://doi.org/10.1111/bpa.12598	journal	July 2018
Infectious Prions in the Saliva and Blood of Deer with Chronic Wasting Disease Mathiason, C. K.; Powers, J. G.; Dahmes, S. J. Science, Vol. 314, Issue 5796 https://doi.org/10.1126/science.1132661	journal	October 2006
Prion Strain Mutation Determined by Prion Protein Conformational Compatibility and Primary Structure Angers, Rachel C.; Kang, Hae-Eun; Napier, Dana Science, Vol. 328, Issue 5982 https://doi.org/10.1126/science.1187107	journal	May 2010
Chronic Wasting Disease (CWD) Susceptibility of Several North American Rodents That Are Sympatric with Cervid CWD Epidemics Heisey, Dennis M.; Mickelsen, Natalie A.; Schneider, Jay R. Journal of Virology, Vol. 84, Issue 1 https://doi.org/10.1128/JVI.00560-09	journal	January 2010
Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains Duque Velásquez, Camilo; Kim, Chiye; Herbst, Allen Journal of Virology, Vol. 89, Issue 24 https://doi.org/10.1128/JVI.02010-15	journal	December 2015
Transmission and Adaptation of Chronic Wasting Disease to Hamsters and Transgenic Mice: Evidence for Strains Raymond, Gregory J.; Raymond, Lynne D.; Meade-White, Kimberly D. Journal of Virology, Vol. 81, Issue 8 https://doi.org/10.1128/JVI.02474-06	journal	April 2007
BSE in Great Britain: consistency of the neurohistopathological findings in two random annual samples of clinically suspect cases Simmons, M. M.; Harris, P.; Jeffrey, M. Veterinary Record, Vol. 138, Issue 8 https://doi.org/10.1136/vr.138.8.175	journal	February 1996
Experimental inoculation of scrapie and chronic wasting disease agents in raccoons (Procyon lotor ) Hamir, A. N.; Miller, J. M.; Cutlip, R. C. Veterinary Record, Vol. 153, Issue 4 https://doi.org/10.1136/vr.153.4.121	journal	July 2003
Neuronal Vacuolation in Raccoons (Procyon lotor) Hamir, A. N.; Heidel, J. R.; Picton, R. Veterinary Pathology, Vol. 34, Issue 3 https://doi.org/10.1177/030098589703400315	journal	May 1997
Raccoons accumulate PrP^Sc after intracranial inoculation of the agents of chronic wasting disease or transmissible mink encephalopathy but not atypical scrapie Moore, S. Jo; Smith, Jodi D.; Richt, Jürgen A. Journal of Veterinary Diagnostic Investigation, Vol. 31, Issue 2 https://doi.org/10.1177/1040638718825290	journal	January 2019
Neuronal Vacuolation in Raccoons from Oregon Hamir, Amir N.; Fischer, Kay A. Journal of Veterinary Diagnostic Investigation, Vol. 11, Issue 4 https://doi.org/10.1177/104063879901100401	journal	July 1999
Scrapie Agent (Strain 263K) Can Transmit Disease via the Oral Route after Persistence in Soil over Years Seidel, Bjoern; Thomzig, Achim; Buschmann, Anne PLoS ONE, Vol. 2, Issue 5 https://doi.org/10.1371/journal.pone.0000435	journal	May 2007
Detection of CWD Prions in Urine and Saliva of Deer by Transgenic Mouse Bioassay Haley, Nicholas J.; Seelig, Davis M.; Zabel, Mark D. PLoS ONE, Vol. 4, Issue 3 https://doi.org/10.1371/journal.pone.0004848	journal	March 2009
Infectious Prions in Pre-Clinical Deer and Transmission of Chronic Wasting Disease Solely by Environmental Exposure Mathiason, Candace K.; Hays, Sheila A.; Powers, Jenny PLoS ONE, Vol. 4, Issue 6 https://doi.org/10.1371/journal.pone.0005916	journal	June 2009
Detection of Sub-Clinical CWD Infection in Conventional Test-Negative Deer Long after Oral Exposure to Urine and Feces from CWD+ Deer Haley, Nicholas J.; Mathiason, Candace K.; Zabel, Mark D. PLoS ONE, Vol. 4, Issue 11 https://doi.org/10.1371/journal.pone.0007990	journal	November 2009
Prion Protein Polymorphisms Affect Chronic Wasting Disease Progression Johnson, Chad J.; Herbst, Allen; Duque-Velasquez, Camilo PLoS ONE, Vol. 6, Issue 3 https://doi.org/10.1371/journal.pone.0017450	journal	March 2011
Rapid Antemortem Detection of CWD Prions in Deer Saliva Henderson, Davin M.; Manca, Matteo; Haley, Nicholas J. PLoS ONE, Vol. 8, Issue 9 https://doi.org/10.1371/journal.pone.0074377	journal	September 2013
Mineral licks as environmental reservoirs of chronic wasting disease prions Plummer, Ian H.; Johnson, Chad J.; Chesney, Alexandra R. PLOS ONE, Vol. 13, Issue 5 https://doi.org/10.1371/journal.pone.0196745	journal	May 2018
Prions Adhere to Soil Minerals and Remain Infectious Johnson, Christopher J.; Phillips, Kristen E.; Schramm, Peter T. PLoS Pathogens, Vol. 2, Issue 4 https://doi.org/10.1371/journal.ppat.0020032	journal	April 2006
Oral Transmissibility of Prion Disease Is Enhanced by Binding to Soil Particles Johnson, Christopher J.; Pedersen, Joel A.; Chappell, Rick J. PLoS Pathogens, Vol. 3, Issue 7 https://doi.org/10.1371/journal.ppat.0030093	journal	July 2007
Emerging prion disease drives host selection in a wildlife population Robinson, Stacie J.; Samuel, Michael D.; Johnson, Chad J. Ecological Applications, Vol. 22, Issue 3 https://doi.org/10.1890/11-0907.1	journal	April 2012
Transport of the Pathogenic Prion Protein through Soils Jacobson, Kurt H.; Lee, Seunghak; Somerville, Robert A. Journal of Environmental Quality, Vol. 39, Issue 4 https://doi.org/10.2134/jeq2009.0137	journal	July 2010
Deer Carcass Decomposition and Potential Scavenger Exposure to Chronic Wasting Disease Jennelle, Christopher S.; Samuel, Michael D.; Nolden, Cherrie A. Journal of Wildlife Management, Vol. 73, Issue 5 https://doi.org/10.2193/2008-282	journal	July 2009
Environmental Sources of Prion Transmission in Mule Deer Miller, Michael W.; Williams, Elizabeth S.; Hobbs, N. Thompson Emerging Infectious Diseases, Vol. 10, Issue 6 https://doi.org/10.3201/eid1006.040010	journal	June 2004
Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion Herbst, Allen; Velásquez, Camilo Duque; Triscott, Elizabeth Emerging Infectious Diseases, Vol. 23, Issue 9 https://doi.org/10.3201/eid2309.161474	journal	September 2017
The role of genetics in chronic wasting disease of North American cervids Robinson, Stacie J.; Samuel, Michael D.; O'Rourke, Katherine I. Prion, Vol. 6, Issue 2 https://doi.org/10.4161/pri.19640	journal	April 2012
Prion Protein gene Heterogeneity in Free-Ranging White-Tailed deer Within the Chronic Wasting Disease Affected Region of Wisconsin Johnson, Chad; Johnson, Jody; Clayton, Murray Journal of Wildlife Diseases, Vol. 39, Issue 3 https://doi.org/10.7589/0090-3558-39.3.576	journal	July 2003
DETECTION OF PrP^CWD IN FECES FROM NATURALLY EXPOSED ROCKY MOUNTAIN ELK (CERVUS ELAPHUS NELSONI) USING PROTEIN MISFOLDING CYCLIC AMPLIFICATION Pulford, Bruce; Spraker, Terry R.; Wyckoff, A. Christy Journal of Wildlife Diseases, Vol. 48, Issue 2 https://doi.org/10.7589/0090-3558-48.2.425	journal	April 2012

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