Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep

Cassmann, Eric D.; Moore, S. Jo; Greenlee, Justin J.

doi:10.3201/eid2712.204978

Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep

Journal Article · Wed Dec 01 00:00:00 EST 2021 · Emerging Infectious Diseases

DOI:https://doi.org/10.3201/eid2712.204978· OSTI ID:1905055

Cassmann, Eric D. ^[1]; Moore, S. Jo ^[2]; Greenlee, Justin J. ^[2]

US Dept. of Agriculture (USDA), Ames, IA (United States); OSTI
US Dept. of Agriculture (USDA), Ames, IA (United States)

Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: US Department of Agriculture; USDOE Office of Science (SC)

Grant/Contract Number:: SC0014664

OSTI ID:: 1905055

Journal Information:: Emerging Infectious Diseases, Journal Name: Emerging Infectious Diseases Journal Issue: 12 Vol. 27; ISSN 1080-6040

Publisher:: Centers for Disease Control and Prevention (CDC)Copyright Statement

Country of Publication:: United States

Language:: English

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