Thin, Flexible Sensors and Actuators as ‘Instrumented’ Surgical Sutures for Targeted Wound Monitoring and Therapy

Kim, Dae-Hyeong; Wang, Shuodao; Keum, Hohyun; Ghaffari, Roozbeh; Kim, Yun-Soung; Tao, Hu; Panilaitis, Bruce; Li, Ming; Kang, Zhan; Omenetto, Fiorenzo; Huang, Yonggang; Rogers, John A.

doi:10.1002/smll.201200933

Title: Thin, Flexible Sensors and Actuators as ‘Instrumented’ Surgical Sutures for Targeted Wound Monitoring and Therapy

Journal Article · Tue Aug 14 00:00:00 EDT 2012 · Small

DOI:https://doi.org/10.1002/smll.201200933· OSTI ID:1876442

Kim, Dae-Hyeong ^[1]; Wang, Shuodao ^[2]; Keum, Hohyun ^[2]; Ghaffari, Roozbeh ^[3]; Kim, Yun-Soung ^[2]; Tao, Hu ^[4]; Panilaitis, Bruce ^[4]; Li, Ming ^[5]; Kang, Zhan ^[5]; Omenetto, Fiorenzo ^[4]; Huang, Yonggang ^[6]; Rogers, John A. ^[2]

Seoul National Univ. (Korea, Republic of)
Univ. of Illinois at Urbana-Champaign, IL (United States)
MC10 Inc., Cambridge, MA (United States)
Tufts Univ., Medford, MA (United States)
Dalian Univ. of Technology (China)
Northwestern Univ., Evanston, IL (United States)

Proper healing of incised skin is critical to the natural processes of tissue repair. Concepts in flexible silicon electronics enable integration of actuators, sensors and a variety of semiconductor devices onto thin strips of plastic or biopolymers, to yield ‘instrumented’ suture threads for monitoring and accelerating the wound healing in this context. Bifacial systems of this type demonstrate various classes of functionality, in live animal models. Furthermore, detailed modelling of the mechanics reveals stress and strain distributions in such applications, to support design strategies for robust operation.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; National Science Foundation (NSF)

Grant/Contract Number:: FG02-07ER46471; #0749028; FG02-07ER46453

OSTI ID:: 1876442

Journal Information:: Small, Vol. 8, Issue 21; ISSN 1613-6810

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

References (23)

Mechanical properties and fracture behaviour of polyimide (SINTIMID) at cryogenic temperatures Tschegg, E.; Humer, K.; Weber, H. W. Cryogenics, Vol. 31, Issue 10 https://doi.org/10.1016/0011-2275(91)90021-N	journal	October 1991
Mechanical properties of pineapple leaf fiber-reinforced polyester composites Devi, L. Uma; Bhagawan, S. S.; Thomas, Sabu Journal of Applied Polymer Science, Vol. 64, Issue 9 https://doi.org/10.1002/(SICI)1097-4628(19970531)64:9<1739::AID-APP10>3.0.CO;2-T	journal	May 1997
Synthesis, assembly and applications of semiconductor nanomembranes Rogers, J. A.; Lagally, M. G.; Nuzzo, R. G. Nature, Vol. 477, Issue 7362, p. 45-53 https://doi.org/10.1038/nature10381	journal	September 2011
Clinical Evaluation of Recombinant Human Platelet-Derived Growth Factor for the Treatment of Lower Extremity Ulcers Steed, David L. Plastic and Reconstructive Surgery, Vol. 117, Issue SUPPLEMENT https://doi.org/10.1097/01.prs.0000222526.21512.4c	journal	January 2006
Flexible Electronics Sensors for Tactile Multi-Touching Chang, Wen-Yang; Fang, Te-Hua; Yeh, Shao-Hsing Sensors, Vol. 9, Issue 2 https://doi.org/10.3390/s9021188	journal	February 2009
A disposable screen-printed silver strip sensor for single drop analysis of halide in biological samples Chiu, Mei-Hsin; Cheng, Wan-Ling; Muthuraman, Govindan Biosensors and Bioelectronics, Vol. 24, Issue 10 https://doi.org/10.1016/j.bios.2009.03.004	journal	June 2009
In Vitro Antimicrobial Evaluation of Coated VICRYL* Plus Antibacterial Suture (Coated Polyglactin 910 with Triclosan) using Zone of Inhibition Assays Rothenburger, Stephen; Spangler, Daniel; Bhende, Shubhangi Surgical Infections, Vol. 3, Issue s1 https://doi.org/10.1089/sur.2002.3.s1-79	journal	December 2002
Carbon nanotube-reinforced epoxy-composites: enhanced stiffness and fracture toughness at low nanotube content Gojny, F. H.; Wichmann, M. H. G.; Köpke, U. Composites Science and Technology, Vol. 64, Issue 15 https://doi.org/10.1016/j.compscitech.2004.04.002	journal	November 2004
Stretchable GaAs Photovoltaics with Designs That Enable High Areal Coverage Lee, Jongho; Wu, Jian; Shi, Mingxing Advanced Materials, Vol. 23, Issue 8 https://doi.org/10.1002/adma.201003961	journal	January 2011
Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field: Nanotube Heating Kills Cancer Cells Gannon, Christopher J.; Cherukuri, Paul; Yakobson, Boris I. Cancer, Vol. 110, Issue 12 https://doi.org/10.1002/cncr.23155	journal	October 2007
Extent of plasma damage to porous organosilicate films characterized with nanoindentation, x-ray reflectivity, and surface acoustic waves Iacopi, F.; Travaly, Y.; Van Hove, M. Journal of Materials Research, Vol. 21, Issue 12 https://doi.org/10.1557/jmr.2006.0386	journal	December 2006
Wound Healing: Relationship of Wound Closing Tension to Scar Width in Rats Burgess, L. P. A.; Morin, G. V.; Rand, M. Archives of Otolaryngology - Head and Neck Surgery, Vol. 116, Issue 7 https://doi.org/10.1001/archotol.1990.01870070046008	journal	July 1990
Electrical and mechanical properties of low temperature evaporated silicon dioxide/polyimide dual-layer insulator for plastic-based polymer transistor Park, Sung Kyu; Kim, Yong Hoon; Han, Jeong In Thin Solid Films, Vol. 429, Issue 1-2 https://doi.org/10.1016/S0040-6090(03)00407-3	journal	April 2003
Global curvature, thickness, and the ideal shapes of knots Gonzalez, Oscar; Maddocks, John H. Proceedings of the National Academy of Sciences, Vol. 96, Issue 9 https://doi.org/10.1073/pnas.96.9.4769	journal	April 1999
Body temperature changes during inflammation: their mediation and nutritional significance Kluger, Matthew J. Proceedings of the Nutrition Society, Vol. 48, Issue 3 https://doi.org/10.1079/PNS19890049	journal	September 1989
Stretchable gold conductors on elastomeric substrates Lacour, Stephanie Perichon; Wagner, Sigurd; Huang, Zhenyu Applied Physics Letters, Vol. 82, Issue 15, p. 2404-2406 https://doi.org/10.1063/1.1565683	journal	April 2003
Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo Viventi, Jonathan; Kim, Dae-Hyeong; Vigeland, Leif Nature Neuroscience, Vol. 14, Issue 12, p. 1599-1605 https://doi.org/10.1038/nn.2973	journal	November 2011
Thermal tumour ablation: Devices, clinical applications and future directions Haemmerich, D.; Laeseke, P. F. International Journal of Hyperthermia, Vol. 21, Issue 8 https://doi.org/10.1080/02656730500226423	journal	December 2005
Flexible organic transistors and circuits with extreme bending stability Sekitani, Tsuyoshi; Zschieschang, Ute; Klauk, Hagen Nature Materials, Vol. 9, Issue 12 https://doi.org/10.1038/nmat2896	journal	November 2010
A Temperature-Sensitive Drug Release System Based on Phase-Change Materials Choi, Sung-Wook; Zhang, Yu; Xia, Younan Angewandte Chemie International Edition, Vol. 49, Issue 43 https://doi.org/10.1002/anie.201004057	journal	September 2010
The Influence of Local Versus Global Heat on the Healing of Chronic Wounds in Patients with Diabetes Petrofsky, Jerrold S.; Lawson, Daryl; Suh, Hye Jin Diabetes Technology & Therapeutics, Vol. 9, Issue 6 https://doi.org/10.1089/dia.2007.0231	journal	December 2007
Biodegradable, Elastic Shape-Memory Polymers for Potential Biomedical Applications Lendlein, Andreas; Langer, Robert Science, Vol. 296, Issue 5573, p. 1673-1676 https://doi.org/10.1126/science.1066102	journal	April 2002
Precious Palladium-Aluminium-Based Alloys with High Hardness and Workability Brelle, Julien; Blatter, Andreas; Ziegenhagen, René Platinum Metals Review, Vol. 53, Issue 4 https://doi.org/10.1595/147106709X472192	journal	October 2009

Cited By (29)

Biodegradable Nanofibrous Polymeric Substrates for Generating Elastic and Flexible Electronics Najafabadi, Alireza Hassani; Tamayol, Ali; Annabi, Nasim Advanced Materials, Vol. 26, Issue 33 https://doi.org/10.1002/adma.201401537	journal	July 2014
Advanced Carbon for Flexible and Wearable Electronics Wang, Chunya; Xia, Kailun; Wang, Huimin Advanced Materials, Vol. 31, Issue 9 https://doi.org/10.1002/adma.201801072	journal	October 2018
Mini Review on Flexible and Wearable Electronics for Monitoring Human Health Information Gu, Yiding; Zhang, Ting; Chen, Hao Nanoscale Research Letters, Vol. 14, Issue 1 https://doi.org/10.1186/s11671-019-3084-x	journal	August 2019
Radiometric Analysis of Ankle Edema via RZF Antenna for Biomedical Applications Ramesh, G. P.; Mohan Kumar, N. Wireless Personal Communications, Vol. 102, Issue 2 https://doi.org/10.1007/s11277-017-5236-6	journal	January 2018
Recent Advances of Flexible Data Storage Devices Based on Organic Nanoscaled Materials Zhou, Li; Mao, Jingyu; Ren, Yi Small, Vol. 14, Issue 10 https://doi.org/10.1002/smll.201703126	journal	January 2018
Environment-friendly carbon nanotube based flexible electronics for noninvasive and wearable healthcare Dinh, Toan; Phan, Hoang-Phuong; Nguyen, Tuan-Khoa Journal of Materials Chemistry C, Vol. 4, Issue 42 https://doi.org/10.1039/c6tc02708c	journal	January 2016
Freestanding, Fiber-Based, Wearable Temperature Sensor with Tunable Thermal Index for Healthcare Monitoring Trung, Tran Quang; Le, Hoang Sinh; Dang, Thi My Linh Advanced Healthcare Materials, Vol. 7, Issue 12 https://doi.org/10.1002/adhm.201800074	journal	May 2018
Wearable Electronics Based on 2D Materials for Human Physiological Information Detection Pang, Yu; Yang, Zhen; Yang, Yi Small, Vol. 16, Issue 15 https://doi.org/10.1002/smll.201901124	journal	July 2019
A smart, stretchable resistive heater textile Li, Yiming; Zhang, Zhitao; Li, Xueyi Journal of Materials Chemistry C, Vol. 5, Issue 1 https://doi.org/10.1039/c6tc04399b	journal	January 2017
Immunologic and Tissue Biocompatibility of Flexible/Stretchable Electronics and Optoelectronics Park, Gayoung; Chung, Hyun-Joong; Kim, Kwanghee Advanced Healthcare Materials, Vol. 3, Issue 4 https://doi.org/10.1002/adhm.201300220	journal	September 2013
Toward Flexible and Wearable Human-Interactive Health-Monitoring Devices Takei, Kuniharu; Honda, Wataru; Harada, Shingo Advanced Healthcare Materials, Vol. 4, Issue 4 https://doi.org/10.1002/adhm.201400546	journal	November 2014
Evaluation of an Electro-Pneumatic Device for Artificial Capillary Pulse Generation used in a Prospective Study in Animals for Surgical Neck Wound Healing Foltyn, J.; Proto, A.; Oczka, D. Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-46397-0	journal	July 2019
Recent Progress on Microelectrodes in Neural Interfaces Kim, Geon; Kim, Kanghyun; Lee, Eunji Materials, Vol. 11, Issue 10 https://doi.org/10.3390/ma11101995	journal	October 2018
FEP Encapsulated Crack-Based Sensor for Measurement in Moisture-Laden Environment Kim, Minho; Choi, Hyesu; Kim, Taewi Materials, Vol. 12, Issue 9 https://doi.org/10.3390/ma12091516	journal	May 2019
Suture materials - Current and emerging trends Dennis, Christopher; Sethu, Swaminathan; Nayak, Sunita Journal of Biomedical Materials Research Part A, Vol. 104, Issue 6 https://doi.org/10.1002/jbm.a.35683	journal	April 2016
Smart Flexible Electronics‐Integrated Wound Dressing for Real‐Time Monitoring and On‐Demand Treatment of Infected Wounds Pang, Qian; Lou, Dong; Li, Shijian Advanced Science, Vol. 7, Issue 6 https://doi.org/10.1002/advs.201902673	journal	March 2020
Highly Stretchable and Transparent Metal Nanowire Heater for Wearable Electronics Applications Hong, Sukjoon; Lee, Habeom; Lee, Jinhwan Advanced Materials, Vol. 27, Issue 32 https://doi.org/10.1002/adma.201500917	journal	July 2015
Ultrasensitive Multi-Functional Flexible Sensors Based on Organic Field-Effect Transistors with Polymer-Dispersed Liquid Crystal Sensing Layers Song, Myeonghun; Seo, Jooyeok; Kim, Hwajeong Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-02160-x	journal	June 2017
Mechanically Gated Electrical Switches by Creasing of Patterned Metal/Elastomer Bilayer Films Xu, Ben; Chen, Dayong; Hayward, Ryan C. Advanced Materials, Vol. 26, Issue 25 https://doi.org/10.1002/adma.201400992	journal	April 2014
A flexible proximity sensor formed by duplex screen/screen-offset printing and its application to non-contact detection of human breathing Nomura, Ken-ichi; Kaji, Ryosaku; Iwata, Shiro Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep19947	journal	January 2016
Microfluidic‐Release Insertion Shuttle Designed for Implanting Flexible Biomedical Electronic Devices into Live Bodies Kwon, Minjeong; Song, Kwangsun; Jung, Dongwuk Advanced Materials Interfaces https://doi.org/10.1002/admi.201900259	journal	April 2019
Soft electrothermal actuators using silver nanowire heaters Yao, Shanshan; Cui, Jianxun; Cui, Zheng Nanoscale, Vol. 9, Issue 11 https://doi.org/10.1039/c6nr09270e	journal	January 2017
Smart Wound Dressings for Diabetic Chronic Wounds Gianino, Elizabeth; Miller, Craig; Gilmore, Jordon Bioengineering https://doi.org/10.20944/preprints201805.0396.v1	journal	May 2018
Flexible and Stretchable Physical Sensor Integrated Platforms for Wearable Human-Activity Monitoringand Personal Healthcare Trung, Tran Quang; Lee, Nae-Eung Advanced Materials, Vol. 28, Issue 22 https://doi.org/10.1002/adma.201504244	journal	February 2016
Recent Progress in Wireless Sensors for Wearable Electronics Park, Young-Geun; Lee, Sangil; Park, Jang-Ung Sensors, Vol. 19, Issue 20 https://doi.org/10.3390/s19204353	journal	October 2019
Omnidirectional Strain‐Independent Organic Transistors Integrated onto an Elastomer Template with a Spontaneously Formed Fingerprint‐Mimicking Microtopography Choi, Giheon; Baek, Seolhee; Oh, Seungtaek Advanced Electronic Materials, Vol. 5, Issue 12 https://doi.org/10.1002/aelm.201900441	journal	September 2019
Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future Mehrali, Mehdi; Bagherifard, Sara; Akbari, Mohsen Advanced Science, Vol. 5, Issue 10 https://doi.org/10.1002/advs.201700931	journal	August 2018
An Ultralight Graphene Honeycomb Sandwich for Stretchable Light‐Emitting Displays Wang, Zhenyu; Liu, Xu; Shen, Xi Advanced Functional Materials, Vol. 28, Issue 19 https://doi.org/10.1002/adfm.201707043	journal	March 2018
Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties Memic, Adnan; Aldhahri, Musab; Tamayol, Ali Nanomaterials, Vol. 7, Issue 3 https://doi.org/10.3390/nano7030063	journal	March 2017

Similar Records

Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing

Journal Article · Wed Mar 26 00:00:00 EDT 2014 · Advanced Healthcare Materials · OSTI ID:1876442

Hattori, Yoshiaki; Falgout, Leo; Lee, Woosik; +27 more

Performance Assessment of Suture Type, Water Temperature, and Surgeon Skill in Juvenile Chinook Salmon Surgically Implanted with Acoustic Transmitters

Journal Article · Sat May 01 00:00:00 EDT 2010 · Transactions of the American Fisheries Society, 139(3):888-899 · OSTI ID:1876442

Deters, Katherine A; Brown, Richard S; Carter, Kathleen M; +3 more

Low-output carbon dioxide laser for cutaneous wound closure of scalpel incisions: comparative tensile strength studies of the laser to the suture and staple for wound closure

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Lasers Surg. Med.; (United States) · OSTI ID:1876442

Garden, J M; Robinson, J K; Taute, P M; +3 more

Related Subjects

60 APPLIED LIFE SCIENCES
flexible electronics
implantable devices
surgical suture

Title: Thin, Flexible Sensors and Actuators as ‘Instrumented’ Surgical Sutures for Targeted Wound Monitoring and Therapy

Citation Formats

References (23)

Cited By (29)

Similar Records

Related Subjects