Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing

Hattori, Yoshiaki; Falgout, Leo; Lee, Woosik; Jung, Sung -Young; Poon, Emily; Lee, Jung Woo; Na, Ilyoun; Geisler, Amelia; Sadhwani, Divya; Zhang, Yihui; Su, Yewang; Wang, Xiaoqi; Liu, Zhuangjian; Xia, Jing; Cheng, Huanyu; Webb, R. Chad; Bonifas, Andrew P.; Won, Philip; Jeong, Jae -Woong; Jang, Kyung -In; Song, Young Min; Nardone, Beatrice; Nodzenski, Michael; Fan, Jonathan A.; Huang, Yonggang; West, Dennis P.; Paller, Amy S.; Alam, Murad; Yeo, Woon -Hong; Rogers, John A.

doi:10.1002/adhm.201400073

Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing

Journal Article · Wed Mar 26 00:00:00 EDT 2014 · Advanced Healthcare Materials

DOI:https://doi.org/10.1002/adhm.201400073· OSTI ID:1342721

Hattori, Yoshiaki ^[1]; Falgout, Leo ^[2]; Lee, Woosik ^[2]; Jung, Sung -Young ^[3]; Poon, Emily ^[4]; Lee, Jung Woo ^[2]; Na, Ilyoun ^[3]; Geisler, Amelia ^[4]; Sadhwani, Divya ^[4]; Zhang, Yihui ^[5]; Su, Yewang ^[5]; Wang, Xiaoqi ^[4]; Liu, Zhuangjian ^[6]; Xia, Jing ^[5]; Cheng, Huanyu ^[7]; Webb, R. Chad ^[2]; Bonifas, Andrew P. ^[2]; Won, Philip ^[2]; Jeong, Jae -Woong ^[2]; Jang, Kyung -In ^[2] more »

Univ. of Illinois at Urbana-Champaign, Urbana, IL (United States); Office of Scientific and Technical Information (OSTI)
Univ. of Illinois at Urbana-Champaign, Urbana, IL (United States)
Pohang Univ. of Science and Technology, Pohang (Republic of Korea)
Northwestern Univ., Chicago, IL (United States)
Northwestern Univ., Evanston, IL (United States); Center for Mechanics and Materials, Beijing (China)
Institute of High Performance Computing, Connexis (Singapore)
Northwestern Univ., Evanston, IL (United States)
Pusan National Univ., Busan (Republic of Korea)
Virginia Commonwealth Univ., Richmond, VA (United States)

Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. In this paper, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of “epidermal” electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. Finally, the results have the potential to address important unmet needs in chronic wound management.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Illinois, Urbana, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: FG02-07ER46453; FG02-07ER46471

OSTI ID:: 1342721

Journal Information:: Advanced Healthcare Materials, Journal Name: Advanced Healthcare Materials Journal Issue: 10 Vol. 3; ISSN 2192-2640

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
clinical study
epidermal electronics
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skin-like
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Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing

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