Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA
Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA, Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA 02139 USA
Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA, Schepens Eye Research Institute Mass Eye and Ear Harvard Medical School Boston MA 02114 USA
Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA, Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA
Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA
VA Boston Healthcare System Brigham and Women's Hospital Harvard Medical School Boston MA 02130 USA
Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA 02139 USA, Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA, Institute for Soldier Nanotechnologies Massachusetts Institute of Technology Cambridge MA 02139 USA
Zwitterionic surfaces are increasingly explored as antifouling coatings due to their propensity to resist protein, bacterial, and cell adhesion and are typically applied as polymeric systems. Here, the self‐assembly of strongly interacting small molecule amphiphiles is reported to produce nanoribbons for antifouling applications. Synthesized amphiphiles spontaneously form micrometers‐long nanoribbons with nanometer‐scale cross‐sections and intrinsically display a dense coating of zwitterionic moieties on their surfaces. Substrates coated with nanoribbons demonstrate concentration‐dependent thicknesses and near superhydrophilicity. These surface coatings are then probed for antifouling properties and substantial reductions are demonstrated in protein adsorption, bacterial biofilm formation, and cell adhesion relative to uncoated controls. Harnessing cohesive small molecule self‐assembling nanomaterials for surface coatings offers a facile route to effective antifouling surfaces.
@article{osti_1874623,
author = {Christoff‐Tempesta, Ty and Deiss‐Yehiely, Elad and Dromel, Pierre C. and Uliassi, Linnaea D. and Chazot, Cécile A. C. and Postelnicu, Eveline and Hart, A. John and Spector, Myron and Hammond, Paula T. and Ortony, Julia H.},
title = {Antifouling Surface Coatings from Self‐Assembled Zwitterionic Aramid Amphiphile Nanoribbons},
annote = {Abstract Zwitterionic surfaces are increasingly explored as antifouling coatings due to their propensity to resist protein, bacterial, and cell adhesion and are typically applied as polymeric systems. Here, the self‐assembly of strongly interacting small molecule amphiphiles is reported to produce nanoribbons for antifouling applications. Synthesized amphiphiles spontaneously form micrometers‐long nanoribbons with nanometer‐scale cross‐sections and intrinsically display a dense coating of zwitterionic moieties on their surfaces. Substrates coated with nanoribbons demonstrate concentration‐dependent thicknesses and near superhydrophilicity. These surface coatings are then probed for antifouling properties and substantial reductions are demonstrated in protein adsorption, bacterial biofilm formation, and cell adhesion relative to uncoated controls. Harnessing cohesive small molecule self‐assembling nanomaterials for surface coatings offers a facile route to effective antifouling surfaces.},
doi = {10.1002/admi.202200311},
url = {https://www.osti.gov/biblio/1874623},
journal = {Advanced Materials Interfaces},
issn = {ISSN 2196-7350},
number = {22},
volume = {9},
place = {Germany},
publisher = {Wiley Blackwell (John Wiley & Sons)},
year = {2022},
month = {06}}
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 370, Issue 1967https://doi.org/10.1098/rsta.2011.0502