Molecular fouling resistance of zwitterionic and amphiphilic initiated chemically vapor-deposited (iCVD) thin films

Journal Article · Fri Aug 08 04:00:00 EDT 2014 · JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

DOI:https://doi.org/10.1080/09205063.2014.951245· OSTI ID:1211360

Yang, R; Goktekin, E; Wang, MH; Gleason, KK

Biofouling is a universal problem in various applications ranging from water purification to implantable biomedical devices. Recent advances in surface modification have created a rich library of antifouling surface chemistries, many of which can be categorized into one of the two groups: hydrophilic surfaces or amphiphilic surfaces. We report the straightforward preparation of antifouling thin film coatings in both categories via initiated chemical vapor deposition. A molecular force spectroscopy-based method is demonstrated as a rapid and quantitative assessment tool for comparing the differences in antifouling characteristics. The fouling propensity of single molecules, as opposed to bulk protein solution or bacterial culture, is assessed. This method allows for the interrogation of molecular interaction without the complication resulted from protein conformational change or micro-organism group interactions. The molecular interaction follows the same trend as bacterial adhesion results obtained previously, demonstrating that molecular force probe is a valid method for the quantification and mechanistic examination of fouling. In addition, the molecular force spectroscopy-based method is able to distinguish differences in antifouling capability that is not resolvable by traditional static protein adsorption tests. To lend further insight into the intrinsic fouling resistance of zwitterionic and amphiphilic surface chemistries, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, advancing and receding water contact angles, and atomic force microscopy are used to elucidate the film properties that are relevant to their antifouling capabilities.

• Sponsoring Organization: USDOE Advanced Research Projects Agency - Energy (ARPA-E)
• DOE Contract Number: AR0000294
• OSTI ID: 1211360
• Journal Information: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, Journal Name: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION Journal Issue: 14-15 Vol. 25; ISSN 0920-5063
• Country of Publication: United States
• Language: English