Intercalation-Activated Layered MoO3 Nanobelts as Biodegradable Nanozymes for Tumor-Specific Photo-Enhanced Catalytic Therapy

Zhou, Zhan; Wang, Yanlong; Peng, Feng; Meng, Fanqi; Zha, Jiajia; Ma, Lu; Du, Yonghua; Peng, Na; Ma, Lufang; Zhang, Qinghua; Gu, Lin; Yin, Wenyan; Gu, Zhanjun; Tan, Chaoliang

doi:10.1002/anie.202115939

Intercalation-Activated Layered MoO₃ Nanobelts as Biodegradable Nanozymes for Tumor-Specific Photo-Enhanced Catalytic Therapy

Journal Article · Tue Jan 25 00:00:00 EST 2022 · Angewandte Chemie (International Edition)

DOI:https://doi.org/10.1002/anie.202115939· OSTI ID:1844569

Zhou, Zhan ^[1]; Wang, Yanlong ^[2]; Peng, Feng ^[3]; Meng, Fanqi ^[4]; Zha, Jiajia ^[5]; Ma, Lu ^[6]; Du, Yonghua ^[6]; Peng, Na ^[7]; Ma, Lufang ^[3]; Zhang, Qinghua ^[8]; Gu, Lin ^[8]; Yin, Wenyan ^[4]; Gu, Zhanjun ^[4]; ^[5]

Luoyang Normal University (China); People’s Hospital of Zhengzhou University (China); Henan Provincial People’s Hospital, Zhengzhou (China)
Chinese Academy of Sciences (CAS), Beijing (China); Wuhan University of Science and Technology, Hubei (China)
Luoyang Normal University (China)
Chinese Academy of Sciences (CAS), Beijing (China)
City Univ. of Hong Kong (China)
Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II)
Wuhan University of Science and Technology, Hubei (China)
Chinese Academy of Sciences (CAS), Beijing (China); University of Chinese Academy of Sciences, Beijing (China)

The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO₃ nanobelts via aqueous intercalation as an efficient biodegradable nanozyme for tumor-specific photo-enhanced catalytic therapy. In this work, the long MoO₃ nanobelts are grinded and then intercalated with Na⁺ and H₂O to obtain the short Na⁺/H₂O co-intercalated MoO_3–x (NH–MoO_3–x) nanobelts. In contrast to the inert MoO₃ nanobelts, the NH–MoO_3–x nanobelts exhibit excellent enzyme-mimicking catalytic activity for generation of reactive oxygen species, which can be further enhanced by the photothermal effect under a 1064 nm laser irradiation. Thus, after bovine serum albumin modification, the NH–MoO_3–x nanobelts can efficiently kill cancer cells in vitro and eliminate tumors in vivo facilitating with 1064 nm laser irradiation.

View Accepted Manuscript (DOE)

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II)

Sponsoring Organization:: Beijing Natural Science Foundation; National Basic Research Programs of China; National Natural Science Foundation of China (NSFC); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0012704

OSTI ID:: 1844569

Alternate ID(s):: OSTI ID: 23148088

Report Number(s):: BNL-222732-2022-JAAM

Journal Information:: Angewandte Chemie (International Edition), Journal Name: Angewandte Chemie (International Edition) Journal Issue: 16 Vol. 61; ISSN 1433-7851

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Intercalation-Activated Layered MoO3 Nanobelts as Biodegradable Nanozymes for Tumor-Specific Photo-Enhanced Catalytic Therapy

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Intercalation-Activated Layered MoO₃ Nanobelts as Biodegradable Nanozymes for Tumor-Specific Photo-Enhanced Catalytic Therapy