Preparation of 2D Polyaniline/MoO3–x Superlattice Nanosheets via Intercalation-Induced Morphological Transformation for Efficient Chemodynamic Therapy

Hu, Tingting; Xue, Baoli; Meng, Fanqi; Ma, Lu; Du, Yonghua; Yu, Shilong; Ye, Ruquan; Li, Hai; Zhang, Qinghua; Gu, Lin; Zhou, Zhan; Liang, Ruizheng; Tan, Chaoliang

doi:10.1002/adhm.202202911

Preparation of 2D Polyaniline/MoO_3–_x Superlattice Nanosheets via Intercalation-Induced Morphological Transformation for Efficient Chemodynamic Therapy

Journal Article · Thu Jan 05 00:00:00 EST 2023 · Advanced Healthcare Materials

DOI:https://doi.org/10.1002/adhm.202202911· OSTI ID:2425494

Hu, Tingting ^[1]; Xue, Baoli ^[2]; Meng, Fanqi ^[3]; Ma, Lu ^[4]; Du, Yonghua ^[4]; Yu, Shilong ^[5]; Ye, Ruquan ^[6]; Li, Hai ^[5]; Zhang, Qinghua ^[3]; Gu, Lin ^[7]; Zhou, Zhan ^[2]; ^[1]; Tan, Chaoliang ^[8]

Beijing University of Chemical Technology (China)
Luoyang Normal University (China)
Chinese Academy of Sciences (CAS), Beijing (China)
Brookhaven National Laboratory (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II)
Nanjing Tech University (China)
City Univ. of Hong Kong, Kowloon (Hong Kong)
Tsinghua Univ., Beijing (China)
City Univ. of Hong Kong, Kowloon (Hong Kong); City Univ. of Hong Kong, Shenzhen (China)

Organic intercalation of layered nanomaterials is an attractive strategy to fabricate organic/inorganic superlattices for a wide range of promising applications. However, the synthesis of 2D organic/inorganic superlattice nanosheets remains a big challenge. In this work, the preparation of 2D polyaniline/MoO_3–x (PANI/MoO_3–x) superlattice nanosheets via intercalation-induced morphological transformation from MoO₃ nanobelts, as efficient Fenton-like reagents for chemodynamic therapy (CDT), is reported. Micrometer-long MoO₃ nanobelts are co-intercalated with Na⁺/H₂O followed by the guest exchange with aniline monomer for in situ polymerization to obtain PANI/MoO_3–x nanosheets. Intriguingly, the PANI intercalation can induce the morphological transformation from long MoO₃ nanobelts to 2D PANI/MoO_3–x nanosheets along with the partial reduction of Mo⁶⁺ to Mo⁵⁺, and generation of rich oxygen vacancies. More importantly, thanks to the PANI intercalation-induced activation, the PANI/MoO_3–x nanosheets exhibit excellent Fenton-like catalytic activity for generation of hydroxyl radical (·OH) by decomposing H₂O₂ compared with the MoO₃ nanobelts. It is speculated that the good conductivity of PANI can facilitate electron transport during the Fenton-like reaction, thereby enhancing the efficiency of CDT. Thus, the polyvinylpyrrolidone-modified PANI/MoO_3–x nanosheets can function as Fenton-like reagents for highly efficient CDT to kill cancer cells and eradicate tumors.

View Accepted Manuscript (DOE)

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF)

Grant/Contract Number:: SC0012704

OSTI ID:: 2425494

Alternate ID(s):: OSTI ID: 1971570

Journal Information:: Advanced Healthcare Materials, Journal Name: Advanced Healthcare Materials Journal Issue: 11 Vol. 12; ISSN 2192-2640

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

References (55)

The age of bioinspired molybdenum‐involved nanozymes: Synthesis, catalytic mechanisms, and biomedical applications Zu, Yan; Yao, Huiqin; Wang, Yifan VIEW, Vol. 2, Issue 3 https://doi.org/10.1002/VIW.20200188	journal	February 2021
A Supermolecular Photosensitizer with Excellent Anticancer Performance in Photodynamic Therapy Liang, Ruizheng; Tian, Rui; Ma, Lina Advanced Functional Materials, Vol. 24, Issue 21 https://doi.org/10.1002/adfm.201303811	journal	February 2014
Synthesis of Pt Hollow Nanodendrites with Enhanced Peroxidase-Like Activity against Bacterial Infections: Implication for Wound Healing Ge, Cuicui; Wu, Renfei; Chong, Yu Advanced Functional Materials, Vol. 28, Issue 28 https://doi.org/10.1002/adfm.201801484	journal	May 2018
Confined Synthesis of Carbon Nitride in a Layered Host Matrix with Unprecedented Solid-State Quantum Yield and Stability Liu, Wendi; Xu, Simin; Guan, Shanyue Advanced Materials, Vol. 30, Issue 2 https://doi.org/10.1002/adma.201704376	journal	November 2017
Layered Intercalation Materials Zhou, Jingyuan; Lin, Zhaoyang; Ren, Huaying Advanced Materials, Vol. 33, Issue 25 https://doi.org/10.1002/adma.202004557	journal	May 2021
Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics Hu, Hui; Feng, Wei; Qian, Xiaoqin Advanced Materials, Vol. 33, Issue 12 https://doi.org/10.1002/adma.202005062	journal	February 2021
Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy Zhou, Yaofeng; Fan, Siyu; Feng, Lili Advanced Materials, Vol. 33, Issue 48 https://doi.org/10.1002/adma.202104223	journal	September 2021
Fe ₃ O ₄ /Ag/Bi ₂ MoO ₆ Photoactivatable Nanozyme for Self‐Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy Cao, Changyu; Zou, Hai; Yang, Nan Advanced Materials, Vol. 33, Issue 52 https://doi.org/10.1002/adma.202106996	journal	October 2021
Multicomponent Transition Metal Dichalcogenide Nanosheets for Imaging‐Guided Photothermal and Chemodynamic Therapy Zhu, Yu; Wang, Yingjie; Williams, Gareth R. Advanced Science, Vol. 7, Issue 23 https://doi.org/10.1002/advs.202000272	journal	September 2020
Molybdenum‐Based Nanomaterials for Photothermal Cancer Therapy Zhou, Zhan; Li, Xiangqian; Hu, Tingting Advanced NanoBiomed Research, Vol. 2, Issue 11 https://doi.org/10.1002/anbr.202200065	journal	October 2022
A Nanozyme with Photo‐Enhanced Dual Enzyme‐Like Activities for Deep Pancreatic Cancer Therapy Li, Shanshan; Shang, Lu; Xu, Bolong Angewandte Chemie International Edition, Vol. 58, Issue 36 https://doi.org/10.1002/anie.201904751	journal	September 2019
Stimuli‐Responsive Manganese Single‐Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions Zhu, Yang; Wang, Wenyu; Cheng, Junjie Angewandte Chemie International Edition, Vol. 60, Issue 17 https://doi.org/10.1002/anie.202017152	journal	March 2021
A Titanium Nitride Nanozyme for pH‐Responsive and Irradiation‐Enhanced Cascade‐Catalytic Tumor Therapy Liu, Jiaming; Wang, Aizhu; Liu, Shihui Angewandte Chemie International Edition, Vol. 60, Issue 48 https://doi.org/10.1002/anie.202106750	journal	September 2021
Intercalation‐Activated Layered MoO ₃ Nanobelts as Biodegradable Nanozymes for Tumor‐Specific Photo‐Enhanced Catalytic Therapy Zhou, Zhan; Wang, Yanlong; Peng, Feng Angewandte Chemie International Edition, Vol. 61, Issue 16 https://doi.org/10.1002/anie.202115939	journal	February 2022
A Sonication‐Activated Valence‐Variable Sono‐Sensitizer/Catalyst for Autography Inhibition/Ferroptosis‐Induced Tumor Nanotherapy Feng, Wei; Liu, Zhonglong; Xia, Lili Angewandte Chemie International Edition, Vol. 61, Issue 48 https://doi.org/10.1002/anie.202212021	journal	October 2022
synthesis of high-quality crystalline α-MoO3 nanobelts Yang, Xiaofei; Tang, Hua; Zhang, Rongxian Crystal Research and Technology, Vol. 46, Issue 4 https://doi.org/10.1002/crat.201100061	journal	March 2011
Oxygen Vacancy‐Engineered PEGylated MoO ₃ _−x Nanoparticles with Superior Sulfite Oxidase Mimetic Activity for Vitamin B1 Detection Chen, Yuan; Chen, Tongming; Wu, Xiaoju Small, Vol. 15, Issue 46 https://doi.org/10.1002/smll.201903153	journal	October 2019
Oxygen‐Deficient Bimetallic Oxide FeWO _X Nanosheets as Peroxidase‐Like Nanozyme for Sensing Cancer via Photoacoustic Imaging Gong, Fei; Yang, Nailin; Wang, Yong Small, Vol. 16, Issue 46 https://doi.org/10.1002/smll.202003496	journal	October 2020
Activating Layered Metal Oxide Nanomaterials via Structural Engineering as Biodegradable Nanoagents for Photothermal Cancer Therapy Zhou, Zhan; Wang, Xianwen; Zhang, Hui Small, Vol. 17, Issue 12 https://doi.org/10.1002/smll.202007486	journal	February 2021
Preparation of Dye Molecule‐Intercalated MoO ₃ Organic/Inorganic Superlattice Nanoparticles for Fluorescence Imaging‐Guided Catalytic Therapy Hu, Tingting; Liu, Qian; Zhou, Zhan Small, Vol. 18, Issue 25 https://doi.org/10.1002/smll.202200595	journal	May 2022
X-ray absorption fine structure spectroscopy in nanomaterials Sun, Zhihu; Liu, Qinghua; Yao, Tao Science China Materials, Vol. 58, Issue 4 https://doi.org/10.1007/s40843-015-0043-4	journal	April 2015
The composition and proposed structure of the alkali metal layered molybdenum bronzes Thomas, Diane M.; McCarron, Eugene M. Materials Research Bulletin, Vol. 21, Issue 8 https://doi.org/10.1016/0025-5408(86)90132-7	journal	August 1986
Toward noble-metal-free visible-light-driven photocatalytic hydrogen evolution: Monodisperse sub–15 nm Ni2P nanoparticles anchored on porous g-C3N4 nanosheets to engineer 0D-2D heterojunction interfaces Zeng, Deqian; Xu, Wanjie; Ong, Wee-Jun Applied Catalysis B: Environmental, Vol. 221 https://doi.org/10.1016/j.apcatb.2017.08.041	journal	February 2018
Enhancement of output power density and performance of direct borohydride-hydrogen peroxide fuel cell using Ni-Pd core-shell nanoparticles on polymeric composite supports (rGO-PANI) as novel electrocatalysts Mahmoodi, Raana; Hosseini, Mir Ghasem; Rasouli, Haleh Applied Catalysis B: Environmental, Vol. 251 https://doi.org/10.1016/j.apcatb.2019.03.064	journal	August 2019
In situ etching growth of defective ZnS nanosheets anchored vertically on layered-double-hydroxide microflowers for accelerated photocatalytic activity Gao, Fan; Lei, Rui; Huang, Xueyan Applied Catalysis B: Environmental, Vol. 292 https://doi.org/10.1016/j.apcatb.2021.120187	journal	September 2021
Hybrid nanostructures: Versatile systems for biomedical applications Mehta, Swapnil; Suresh, Akhil; Nayak, Yogendra Coordination Chemistry Reviews, Vol. 460 https://doi.org/10.1016/j.ccr.2022.214482	journal	June 2022
High Energy Density Ternary Composite Electrode Material Based on Polyaniline (PANI), Molybdenum trioxide (MoO3) and Graphene Nanoplatelets (GNP) Prepared by Sono-Chemical Method and Their Synergistic Contributions in Superior Supercapacitive Performance Das, Amit Kumar; Karan, Sumanta Kumar; Khatua, B. B. Electrochimica Acta, Vol. 180 https://doi.org/10.1016/j.electacta.2015.08.029	journal	October 2015
Recent progress of chemodynamic therapy-induced combination cancer therapy Wang, Xianwen; Zhong, Xianyan; Liu, Zhuang Nano Today, Vol. 35 https://doi.org/10.1016/j.nantod.2020.100946	journal	December 2020
Nickel metal-organic framework 2D nanosheets with enhanced peroxidase nanozyme activity for colorimetric detection of H2O2 Chen, Jingyuan; Shu, Yun; Li, Huilei Talanta, Vol. 189 https://doi.org/10.1016/j.talanta.2018.06.075	journal	November 2018
Biomedicine Meets Fenton Chemistry Tang, Zhongmin; Zhao, Peiran; Wang, Han Chemical Reviews, Vol. 121, Issue 4 https://doi.org/10.1021/acs.chemrev.0c00977	journal	January 2021
Emerging Two-Dimensional Nanomaterials for Electrocatalysis Jin, Huanyu; Guo, Chunxian; Liu, Xin Chemical Reviews, Vol. 118, Issue 13 https://doi.org/10.1021/acs.chemrev.7b00689	journal	March 2018
Two-Dimensional Metal Nanomaterials: Synthesis, Properties, and Applications Chen, Ye; Fan, Zhanxi; Zhang, Zhicheng Chemical Reviews, Vol. 118, Issue 13 https://doi.org/10.1021/acs.chemrev.7b00727	journal	June 2018
Uncovering the Effects of Metal Contacts on Monolayer MoS ₂ Schauble, Kirstin; Zakhidov, Dante; Yalon, Eilam ACS Nano, Vol. 14, Issue 11 https://doi.org/10.1021/acsnano.0c03515	journal	September 2020
Albumin-Based Therapeutics Capable of Glutathione Consumption and Hydrogen Peroxide Generation for Synergetic Chemodynamic and Chemotherapy of Cancer Yang, Guangbao; Wang, Dongdong; Phua, Soo Zeng Fiona ACS Nano, Vol. 16, Issue 2 https://doi.org/10.1021/acsnano.1c08536	journal	February 2022
Interlayer Coupling: An Additional Degree of Freedom in Two-Dimensional Materials Pei, Shenghai; Wang, Zenghui; Xia, Juan ACS Nano, Vol. 16, Issue 8 https://doi.org/10.1021/acsnano.1c11498	journal	August 2022
Immunogenic Cell Death Augmented by Manganese Zinc Sulfide Nanoparticles for Metastatic Melanoma Immunotherapy Li, Zhu; Chu, Zhaoyou; Yang, Juan ACS Nano, Vol. 16, Issue 9 https://doi.org/10.1021/acsnano.2c08013	journal	August 2022
Pd–Ir Core–Shell Nanocubes: A Type of Highly Efficient and Versatile Peroxidase Mimic Xia, Xiaohu; Zhang, Jingtuo; Lu, Ning ACS Nano, Vol. 9, Issue 10 https://doi.org/10.1021/acsnano.5b03525	journal	September 2015
Defect Engineering Enables Synergistic Action of Enzyme-Mimicking Active Centers for High-Efficiency Tumor Therapy Yu, Bin; Wang, Wei; Sun, Wenbo Journal of the American Chemical Society, Vol. 143, Issue 23 https://doi.org/10.1021/jacs.1c03510	journal	June 2021
Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy Hu, Xi; Li, Fangyuan; Xia, Fan Journal of the American Chemical Society, Vol. 142, Issue 3 https://doi.org/10.1021/jacs.9b13586	journal	December 2019
Li-Ion Intercalation in Thermal Oxide Thin Films of MoO ₃ as Studied by XPS, RBS, and NRA Światowska-Mrowiecka, Jolanta; de Diesbach, Soline; Maurice, Vincent The Journal of Physical Chemistry C, Vol. 112, Issue 29 https://doi.org/10.1021/jp800147f	journal	June 2008
Metallic transport in polyaniline Lee, Kwanghee; Cho, Shinuk; Heum Park, Sung Nature, Vol. 441, Issue 7089 https://doi.org/10.1038/nature04705	journal	May 2006
Monolayer atomic crystal molecular superlattices Wang, Chen; He, Qiyuan; Halim, Udayabagya Nature, Vol. 555, Issue 7695 https://doi.org/10.1038/nature25774	journal	March 2018
Flexible n-type thermoelectric materials by organic intercalation of layered transition metal dichalcogenide TiS2 Wan, Chunlei; Gu, Xiaokun; Dang, Feng Nature Materials, Vol. 14, Issue 6 https://doi.org/10.1038/nmat4251	journal	April 2015
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles Gao, Lizeng; Zhuang, Jie; Nie, Leng Nature Nanotechnology, Vol. 2, Issue 9 https://doi.org/10.1038/nnano.2007.260	journal	August 2007
Nano-photosensitizer based on layered double hydroxide and isophthalic acid for singlet oxygenation and photodynamic therapy Gao, Rui; Mei, Xuan; Yan, Dongpeng Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-05223-3	journal	July 2018
Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy Hu, Kuan; Xie, Lin; Zhang, Yiding Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-16513-0	journal	June 2020
Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy Shen, Weicheng; Hu, Tingting; Liu, Xueyan Nature Communications, Vol. 13, Issue 1 https://doi.org/10.1038/s41467-022-31106-9	journal	June 2022
Chiral molecular intercalation superlattices Qian, Qi; Ren, Huaying; Zhou, Jingyuan Nature, Vol. 606, Issue 7916 https://doi.org/10.1038/s41586-022-04846-3	journal	June 2022
Low-cost and high energy density asymmetric supercapacitors based on polyaniline nanotubes and MoO₃ nanobelts Peng, Hui; Ma, Guofu; Mu, Jingjing J. Mater. Chem. A, Vol. 2, Issue 27 https://doi.org/10.1039/C4TA01899K	journal	January 2014
The effects of the Mo–Sn contact interface on the oxidation reaction of dimethyl ether to methyl formate at a low reaction temperature Zhang, Zhenzhou; Zhang, Qingde; Jia, Lingyu Catalysis Science & Technology, Vol. 6, Issue 15 https://doi.org/10.1039/C6CY00460A	journal	January 2016
Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy Lin, Han; Chen, Yu; Shi, Jianlin Chemical Society Reviews, Vol. 47, Issue 6 https://doi.org/10.1039/C7CS00471K	journal	January 2018
Layered double hydroxide-based nanomaterials for biomedical applications Hu, Tingting; Gu, Zi; Williams, Gareth R. Chemical Society Reviews, Vol. 51, Issue 14 https://doi.org/10.1039/D2CS00236A	journal	January 2022
Wafer-scale synthesis of monolayer two-dimensional porphyrin polymers for hybrid superlattices Zhong, Yu; Cheng, Baorui; Park, Chibeom Science, Vol. 366, Issue 6471 https://doi.org/10.1126/science.aax9385	journal	November 2019
Composite of Manganese Dioxide and Two-dimensional Materials Applied to Supercapacitors Wang, Yi; Huo, Wangchen; Yuan, Xiaoya Acta Physico-Chimica Sinica, Vol. 36, Issue 2 https://doi.org/10.3866/PKU.WHXB201904007	journal	January 2020
Recent Progress on Two-Dimensional Materials Chang, Cheng; Chen, Wei; Chen, Ye Acta Physico Chimica Sinica, Vol. 0, Issue 0 https://doi.org/10.3866/PKU.WHXB202108017	journal	January 2021

Similar Records

Synthesis, structure and electrochemical properties of polyaniline/MoO{sub 3} nanobelt composite for lithium battery

Journal Article · Thu Feb 14 23:00:00 EST 2013 · Materials Research Bulletin · OSTI ID:22215828

Intercalation-Activated Layered MoO₃ Nanobelts as Biodegradable Nanozymes for Tumor-Specific Photo-Enhanced Catalytic Therapy

Journal Article · Mon Jan 24 19:00:00 EST 2022 · Angewandte Chemie (International Edition) · OSTI ID:1844569

Related Subjects

2D materials
60 APPLIED LIFE SCIENCES
Fenton-like reaction
chemodynamic therapy
polyaniline
superlattice nanosheets

Preparation of 2D Polyaniline/MoO3–x Superlattice Nanosheets via Intercalation-Induced Morphological Transformation for Efficient Chemodynamic Therapy

Citation Formats

References (55)

Similar Records

Related Subjects

Preparation of 2D Polyaniline/MoO_3–_x Superlattice Nanosheets via Intercalation-Induced Morphological Transformation for Efficient Chemodynamic Therapy