Activating Layered Metal Oxide Nanomaterials via Structural Engineering as Biodegradable Nanoagents for Photothermal Cancer Therapy

Zhou, Zhan; Wang, Xianwen; Zhang, Hui; Huang, Haoxin; Sun, Lina; Ma, Lu; Du, Yonghua; Pei, Chengjie; Zhang, Qinghua; Li, Hai; Ma, Lufang; Gu, Lin; Liu, Zhuang; Cheng, Liang; Tan, Chaoliang

doi:10.1002/smll.202007486

Activating Layered Metal Oxide Nanomaterials via Structural Engineering as Biodegradable Nanoagents for Photothermal Cancer Therapy

Journal Article · Tue Feb 16 00:00:00 EST 2021 · Small

DOI:https://doi.org/10.1002/smll.202007486· OSTI ID:1773136

Zhou, Zhan ^[1]; Wang, Xianwen ^[2]; Zhang, Hui ^[3]; Huang, Haoxin ^[4]; Sun, Lina ^[2]; Ma, Lu ^[5]; Du, Yonghua ^[6]; Pei, Chengjie ^[7]; Zhang, Qinghua ^[8]; Li, Hai ^[7]; Ma, Lufang ^[9]; Gu, Lin ^[8]; Liu, Zhuang ^[2]; Cheng, Liang ^[2]; ^[4]

Luoyang Normal University (China)
Soochow University, Suzhou (China)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
City Univ. of Hong Kong, Kowloon (Hong Kong)
Luoyang Normal University (China); Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II)
Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II)
Nanjing Tech University (NanjingTech) (China)
Chinese Academy of Sciences (CAS), Beijing (China); University of Chinese Academy of Sciences, Beijing (China)
College of Chemistry and Chemical Engineering Henan Key Laboratory of Function‐Oriented Porous Materials Luoyang Normal University Luoyang 471934 China

Layered metal oxides including MoO₃ and WO₃ have been widely explored for biological applications owing to their excellent biocompatibility, low toxicity, and easy preparation. However, they normally exhibit weak or negligible near-infrared (NIR) absorption and thus are inefficient for photo-induced biomedical applications. Herein, the structural engineering of layered MoO₃ and WO₃ nanostructures is first reported to activate their NIR-II absorption for efficient photothermal cancer therapy in the NIR-II window. White-colored micrometre-long MoO₃ nanobelts are transformed into blue-colored short, thin, defective, interlayer gap-expanded MoO_3–x nanobelts with a strong NIR-II absorption via the simple lithium treatment. The blue MoO_3–x nanobelts exhibit a large extinction coefficient of 18.2 L g^–1 cm^–1 and high photothermal conversion efficiency of 46.9% at 1064 nm. After surface modification, the MoO_3–x nanobelts can be used as a robust nanoagent for photoacoustic imaging-guided photothermal therapy to achieve efficient cancer cell ablation and tumor eradication under irradiation by a 1064 nm laser. Importantly, the biodegradable MoO_3–x nanobelts can be rapidly degraded and excreted from body. We report the study highlights that the structural engineering of layered metal oxides is a powerful strategy to tune their properties and thus boost their performances in given applications.

View Accepted Manuscript (DOE)

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II)

Sponsoring Organization:: National Natural Science Foundation of China (NSFC); USDOE; USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0012704

OSTI ID:: 1773136

Alternate ID(s):: OSTI ID: 1777632

Report Number(s):: BNL-221205-2021-JAAM

Journal Information:: Small, Journal Name: Small Journal Issue: 12 Vol. 17; ISSN 1613-6810

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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