Mapping of the Tuple1 gene to mouse chromosome 16A-B1

Journal Article · Sat Oct 01 00:00:00 EDT 1994 · Genomics

DOI:https://doi.org/10.1006/geno.1994.1568· OSTI ID:183720

Mattei, M G ^[1]; Halford, S; Scambler, P J ^[2]

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1. Faculte de Medicine, Marseille (France)
2. Institute of Child Health, London (United Kingdom)

The human TUPLE1 gene encodes a putative transcriptional regulator and maps to chromosome 22, and therefore may play a role in Di-George syndrome (DGS), relo-cardio-facial syndrome (VCFS), or a related pathology. The murine TUPLE1 gene has also been cloned and shows strong sequence similarity to TUPLE1. Comparative mapping is useful in the study of chromosome evolution and is sometimes able to indicate possible mouse mutations that are potential models of human genetic disorders. As TIPLE1 is a candidate gene for the haploinsufficient phenotype in DGS, we mapped TUPLE1 to mouse chromosome 16A-B1. 6 refs., 1 fig.

• OSTI ID: 183720
• Journal Information: Genomics, Vol. 23, Issue 3; Other Information: PBD: Oct 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
MICE
CONGENITAL MALFORMATIONS
BIOLOGICAL MODELS
GENES
TRANSCRIPTION
GENETIC MAPPING
DNA SEQUENCING
GENE MUTATIONS
HUMAN CHROMOSOME 22
CHROMOSOMES
DNA HYBRIDIZATION
PROTEINS
TRANSCRIPTION FACTORS