Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q
The protein-tyrosine kinase gene Itk is expressed preferentially in T lymphoid cells of the mouse and is induced by IL-2. A related gene, Btk, is expressed in the murine B lymphoid and myeloid lineages. Because mutations in Btk and the corresponding human gene are associated with X-linked immunodeficiency syndromes, it was of interest to map Itk and its human counterpart. By Southern blot analysis of DNA from the progeny of two multilocus crosses, murine Itk was mapped to chromosome 11. By fluorescence in situ hybridization, human ITK was mapped to 5q32-q33. Murine Itk and its human homologue lie within regions of conserved synteny that includes several growth factor and growth factor receptor genes. This region in humans is frequently deleted in the myelodysplastic syndrome, suggesting possible involvement of ITK in this disorder. 20 refs., 2 figs.
- OSTI ID:
- 186075
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 23; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
Similar Records
Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C
Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome
Related Subjects
BASIC STUDIES
BIOLOGICAL MARKERS
CHROMOSOMES
DNA HYBRIDIZATION
FLUORESCENCE
GENE MUTATIONS
GENES
GENETIC MAPPING
GROWTH FACTORS
HEREDITARY DISEASES
HUMAN CHROMOSOME 5
HUMAN X CHROMOSOME
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
MICE
NUCLEOTIDES
PATIENTS
PHOSPHOTRANSFERASES
RECEPTORS
RFLPS
TYROSINE