The human and mouse receptors of hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11

Journal Article · Wed Nov 01 04:00:00 EST 1995 · Genomics

DOI:https://doi.org/10.1006/geno.1995.0022· OSTI ID:273465

Spicer, A P; McDonald, J A ^[1]; Roller, M L; Camper, S A ^[2]

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1. Mayo Clinic Scottsdale, AZ (United States)
2. Univ. of Michigan Medical School, Ann Arbor, MI (United States); and others

The gene for the receptor for hyaluronan-mediated motility, RHAAM (designated hyaluronan-mediated motility receptor, HMMR (human) and Hmmr (mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid analyses. Investigation of two interspecific back-crosses localized the mouse RHAMM (Hmmr) locus 18 cM from the centromere of mouse chromosome 11 within a region of synteny homology with human chromosome 5q23-q35 genes. The map position of the human RHAMM gene places it in a region comparatively rich in disease-associated genes, including those for low-frequency hearing loss, dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q-syndrome. The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias. 18 refs., 1 fig.

• Sponsoring Organization: USDOE
• OSTI ID: 273465
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 30; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
GENE REGULATION
GENES
GENETIC MAPPING
HEREDITARY DISEASES
HUMAN CHROMOSOME 14
HUMAN CHROMOSOME 5
HYBRIDIZATION
LEUKEMIA
LIGANDS
MICE
RADIATION INDUCED MUTANTS
RECEPTORS
SOMATIC CELLS