Structure and chromosomal localization of the human PD-1 gene (PDCD1)

Journal Article · Sat Oct 01 00:00:00 EDT 1994 · Genomics

DOI:https://doi.org/10.1006/geno.1994.1562· OSTI ID:183707

Shinohara, T; Ishida, Y; Kawaichi, M ^[1]

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1. Kyoto Prefectural Medical School, Sakyo-ku (Japan); and others

A cDNA encoding mouse PD-1, a member of the immunoglobulin superfamily, was previously isolated from apoptosis-induced cells by subtractive hybridization. To determine the structure and chromosomal location of the human PD-1 gene, we screened a human T cell cDNA library by mouse PD-1 probe and isolated a cDNA coding for the human PD-1 protein. The deduced amino acid sequence of human PD-1 was 60% identical to the mouse counterpart, and a putative tyrosine kinase-association motif was well conserved. The human PD-1 gene was mapped to 2q37.3 by chromosomal in situ hybridization. 7 refs., 3 figs.

• OSTI ID: 183707
• Journal Information: Genomics, Vol. 23, Issue 3; Other Information: PBD: Oct 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
STRUCTURE-ACTIVITY RELATIONSHIPS
GENETIC MAPPING
TRANSCRIPTION
DNA-CLONING
HUMAN CHROMOSOME 2
ANIMAL CELLS
HYBRIDIZATION
PROTEINS
AMINO ACID SEQUENCE
MICE
TYROSINE
PHOSPHOTRANSFERASES
DNA HYBRIDIZATION
IMMUNOGLOBULINS
GENE RECOMBINATION
PROBES
FLUORESCENCE