Thirdhand cigarette smoke leads to age-dependent and persistent alterations in the cecal microbiome of mice

He, Li; Zhou, Yan‐Xia; Zhang, Yuqing; Hang, Bo; Chang, Hang; Schick, Suzaynn F.; Celniker, Susan E.; Xia, Yankai; Snijders, Antoine M.; Mao, Jian‐Hua

doi:10.1002/mbo3.1198

Thirdhand cigarette smoke leads to age-dependent and persistent alterations in the cecal microbiome of mice

Journal Article · Sat May 15 00:00:00 EDT 2021 · MicrobiologyOpen

DOI:https://doi.org/10.1002/mbo3.1198· OSTI ID:1816036

He, Li ^[1]; Zhou, Yan‐Xia ^[2]; Zhang, Yuqing ^[3]; Hang, Bo ^[4]; Chang, Hang ^[4]; Schick, Suzaynn F. ^[5]; Celniker, Susan E. ^[4]; Xia, Yankai ^[6]; ^[4]; ^[4]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division; Wuhan Univ. (China). Zhongnan Hospital. Dept. of Hematology; OSTI
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division; Univ. Weihai (China). Marine College Shandong
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division; Nanjing Medical Univ. (China). Inst. of Toxicology. State Key Lab. of Reproductive Medicine
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division
Univ. of California, San Francisco, CA (United States). Dept. of Medicine. Division of Occupational and Environmental Medicine
Nanjing Medical Univ. (China). Inst. of Toxicology. State Key Lab. of Reproductive Medicine

The gut microbiome composition is influenced by many factors including environmental exposures. Here, we investigated the effect of thirdhand cigarette smoke (THS) and exposure age on gut microbiome diversity. C57BL/6 mice were exposed to THS at human exposure relevant levels for three weeks during three different life stages: postnatal (0–3 weeks of age), pubescent (4–7 weeks of age), and adult (9–12 weeks of age), respectively. Cecal microbiome profiles were assessed at 17 weeks of age by 16S rRNA gene sequencing. We found that age at THS exposure strongly influenced the cecal microbiome composition. Although postnatal THS exposure significantly influenced the microbial composition, pubescent and adulthood exposures only had minor effects. The microbiome of postnatally THS-exposed mice significantly increased several degradation pathways that regulate glycolysis and pyruvate decarboxylation, and significantly decreased coenzyme A biosynthesis and pyrimidine deoxyribonucleoside salvage. Our results indicate that mouse postnatal development is particularly susceptible to persistent THS exposure effects on the gut microbiome.

View Accepted Manuscript (DOE)

Sponsoring Organization:: National Natural Science Foundation of China (NSFC); Natural Science Foundation of Shandong Province; US-China Program for Biomedical Collaborative Research; USDOE Office of Science (SC); University of California

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1816036

Journal Information:: MicrobiologyOpen, Journal Name: MicrobiologyOpen Journal Issue: 3 Vol. 10; ISSN 2045-8827

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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