Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice

Hang, Bo; Snijders, Antoine M.; Huang, Yurong; Schick, Suzaynn F.; Wang, Pin; Xia, Yankai; Havel, Christopher; Jacob, Peyton; Benowitz, Neal; Destaillats, Hugo; Gundel, Lara A.; Mao, Jian-Hua

doi:10.1038/srep41915

Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice

Journal Article · Fri Feb 03 00:00:00 EST 2017 · Scientific Reports

DOI:https://doi.org/10.1038/srep41915· OSTI ID:1379722

Hang, Bo ^[1]; Snijders, Antoine M. ^[1]; Huang, Yurong ^[1]; Schick, Suzaynn F. ^[2]; Wang, Pin ^[3]; Xia, Yankai ^[4]; Havel, Christopher ^[2]; Jacob, Peyton ^[2]; Benowitz, Neal ^[2]; Destaillats, Hugo ^[5]; Gundel, Lara A. ^[5]; Mao, Jian-Hua ^[1]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division
Univ. of California, San Francisco, CA (United States). Dept. of Medicine, Division of Occupational and Environmental Medicine
Nanjing Medical Univ. (China). Dept. of Gastroenterology
Nanjing Medical Univ. (China). Inst. of Toxicology
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Thirdhand smoke (THS) is the fraction of cigarette smoke that persists in indoor environments after smoking. We investigated the effects of neonatal and adult THS exposure on bodyweight and blood cell populations in C57BL/6 J mice. At the end of neonatal exposure, THS-treated male and female mice had significantly lower bodyweight than their respective control mice. However, five weeks after neonatal exposure ended, THS-treated mice weighed the same as controls. In contrast, adult THS exposure did not change bodyweight of mice. On the other hand, both neonatal and adult THS exposure had profound effects on the hematopoietic system. Fourteen weeks after neonatal THS exposure ended, eosinophil number and platelet volume were significantly higher, while hematocrit, mean cell volume, and platelet counts were significantly lower compared to control. Similarly, adult THS exposure also decreased platelet counts and increased neutrophil counts. Moreover, both neonatal and adult THS exposure caused a significant increase in percentage of B-cells and significantly decreased percentage of myeloid cells. Our results demonstrate that neonatal THS exposure decreases bodyweight and that THS exposure induces persistent changes in the hematopoietic system independent of age at exposure. These results also suggest that THS exposure may have adverse effects on human health.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1379722

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Vol. 7; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Experimental Acute Exposure to Thirdhand Smoke and Changes in the Human Nasal Epithelial Transcriptome Pozuelos, Giovanna L.; Kagda, Meenakshi S.; Schick, Suzaynn JAMA Network Open, Vol. 2, Issue 6 https://doi.org/10.1001/jamanetworkopen.2019.6362	journal	June 2019
Thirdhand smoke: Genotoxicity and carcinogenic potential Hang, Bo; Wang, Pin; Zhao, Yue Chronic Diseases and Translational Medicine, Vol. 6, Issue 1 https://doi.org/10.1016/j.cdtm.2019.08.002	journal	March 2020
Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice Hang, Bo; Wang, Yunshan; Huang, Yurong Clinical Science, Vol. 132, Issue 4 https://doi.org/10.1042/cs20171521	journal	February 2018
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