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Title: Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice

Journal Article · · Clinical Science (1979)
DOI:https://doi.org/10.1042/cs20171521· OSTI ID:1624993
 [1];  [2];  [1];  [3];  [1];  [1];  [1];  [4];  [4];  [4];  [4];  [5];  [5];  [6];  [7];  [1];  [1];  [1]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
  2. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Shandong Univ., Weihai, SD (China)
  3. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Nanjing Univ. Medical School, Jiangsu (China)
  4. Univ. of California, San Francisco, CA (United States)
  5. Indoor Environment Group, Energy Technologies Area, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U.S.A.
  6. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 211166, China
  7. Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA 95817, U.S.A.
+ Show Author Affiliations

Exposure to thirdhand smoke (THS) is a recently described health concern that arises in many indoor environments. However, the carcinogenic potential of THS, a critical consideration in risk assessment, remains untested. Here we investigated the effects of short-term early exposure to THS on lung carcinogenesis in A/J mice. Forty weeks after THS exposure from 4 to 7 weeks of age, the mice had increased incidence of lung adenocarcinoma, tumor size and, multiplicity, compared with controls. In vitro studies using cultured human lung cancer cells showed that THS exposure induced DNA double-strand breaks and increased cell proliferation and colony formation. RNA sequencing analysis revealed that THS exposure induced endoplasmic reticulum stress and activated p53 signaling. Activation of the p53 pathway was confirmed by an increase in its targets p21 and BAX. These data indicate that early exposure to THS is associated with increased lung cancer risk.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
University of California Tobacco-Related Disease Research Program (TRDRP); USDOE Laboratory Directed Research and Development (LDRD) Program; National Institute on Drug Abuse (NIDA); National Center for Research Resources; China Postdoctoral International Exchange Program 2015; National Natural Science Foundation of China (NSFC); Postdoctoral Science Foundation of China
Grant/Contract Number:
AC02-05CH11231; 24RT-0038; 23PT-0013; P30 DA012393; S10 RR026437; 81402193
OSTI ID:
1624993
Journal Information:
Clinical Science (1979), Vol. 132, Issue 4; ISSN 0143-5221
Publisher:
Portland PressCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 20 works
Citation information provided by
Web of Science

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Cited By (6)

Public Facility Utility and Third-Hand Smoking Exposure without First and Second-Hand Smoking According to Urinary Cotinine Level journal March 2019
Differential expression of TLRs and AKAP3 in cigarette smoked mice testis journal April 2019
Experimental Acute Exposure to Thirdhand Smoke and Changes in the Human Nasal Epithelial Transcriptome journal June 2019
Thirdhand smoke: Genotoxicity and carcinogenic potential journal March 2020
Evaluation of serum exosomal LncRNA-based biomarker panel for diagnosis and recurrence prediction of bladder cancer journal November 2018
Household Smoking Status and Heavy Metal Concentrations in Toenails of Children journal October 2019

Figures / Tables (7)

Table 1(p. 4)table Table 1
Figure 1(p. 6)figure Figure 1
Figure 2(p. 7)figure Figure 2
Figure 3(p. 8)figure Figure 3
Figure 4(p. 9)figure Figure 4
Figure 5(p. 10)figure Figure 5
Figure 6(p. 11)figure Figure 6

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
research & experimental medicine
cigarette smoke
DNA double strand breaks
lung carcinogenesis
thirdhand smoke
cancer
cell cycle
growth & proliferation
respiratory system