Accurate determination of production data of the non-standard positron emitter 86Y via the 86Sr(p,n)-reaction

Uddin, M. Shuza; Scholten, Bernhard; Basunia, M. Shamsuzzhoha; Sudár, Sandor; Spellerberg, Stefan; Voyles, Andrew S.; Morrell, Jonathan T.; Zaneb, Haleema; Rios, Jesus A.; Spahn, Ingo; Bernstein, Lee A.; Neumaier, Bernd; Qaim, Syed M.

doi:10.1515/ract-2020-0021

Accurate determination of production data of the non-standard positron emitter ⁸⁶Y via the ⁸⁶Sr(p,n)-reaction

Journal Article · Fri Sep 25 00:00:00 EDT 2020 · Radiochimica Acta

DOI:https://doi.org/10.1515/ract-2020-0021· OSTI ID:1771955

Uddin, M. Shuza ^[1]; Scholten, Bernhard ^[2]; Basunia, M. Shamsuzzhoha ^[3]; Sudár, Sandor ^[4]; Spellerberg, Stefan ^[2]; Voyles, Andrew S. ^[3]; Morrell, Jonathan T. ^[3]; Zaneb, Haleema ^[3]; Rios, Jesus A. ^[3]; Spahn, Ingo ^[2]; Bernstein, Lee A. ^[3]; Neumaier, Bernd ^[2]; Qaim, Syed M. ^[2]

Forschungszentrum Juelich (Germany); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Atomic Energy Research Establishment, Savar, Dhaka (Bangladesh). Tandem Accelerator Facilities
Forschungszentrum Juelich (Germany)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Debrecen Univ. (Hungary)

In view of several significant discrepancies in the excitation function of the ⁸⁶Sr(p,n)^86g+xmY reaction which is the method of choice for the production of the non-standard positron emitter ⁸⁶Y for theranostic application, we carried out a careful measurement of the cross sections of this reaction from its threshold up to 16.2 MeV at Forschungszentrum Jülich (FZJ) and from 14.3 to 24.5 MeV at LBNL. Thin samples of 96.4% enriched ⁸⁶SrCO₃ were prepared by sedimentation and, after irradiation with protons in a stacked-form, the induced radioactivity was measured by high-resolution γ-ray spectrometry. The projectile flux was determined by using the monitor reactions ^natCu(p,xn)^62,63,65Zn and ^natTi(p,x)⁴⁸V, and the calculated proton energy for each sample was verified by considering the ratios of two reaction products of different thresholds. Additionally, the experimental cross section data obtained agreed well with the results of a nuclear model calculation based on the code TALYS. From the cross section data, the integral yield of ⁸⁶Y was calculated. Over the optimum production energy range E_p = 14 → 7 MeV the yield of ⁸⁶Y amounts to 291 MBq/μA for 1 h irradiation time. This value is appreciably lower than the previous literature values calculated from measured and evaluated excitation functions. It is, however, more compatible with the experimental yields of ⁸⁶Y obtained in clinical scale production runs. The levels of the isotopic impurities ^87mY, ^87gY, and ⁸⁸Y were also estimated and found to be <2% in sum.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1771955

Alternate ID(s):: OSTI ID: 22947488

Journal Information:: Radiochimica Acta, Journal Name: Radiochimica Acta Journal Issue: 9 Vol. 108; ISSN 0033-8230

Publisher:: de GruyterCopyright Statement

Country of Publication:: United States

Language:: English

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Accurate determination of production data of the non-standard positron emitter ⁸⁶Y via the ⁸⁶Sr(p,n)-reaction