Nickel–Platinum Nanoparticles as Peroxidase Mimics with a Record High Catalytic Efficiency

Xi, Zheng; Wei, Kecheng; Wang, Qingxiao; Kim, Moon J.; Sun, Shouheng; Fung, Victor; Xia, Xiaohu

doi:10.1021/jacs.0c12605

Nickel–Platinum Nanoparticles as Peroxidase Mimics with a Record High Catalytic Efficiency

Journal Article · Wed Jan 27 00:00:00 EST 2021 · Journal of the American Chemical Society

DOI:https://doi.org/10.1021/jacs.0c12605· OSTI ID:1766375

^[1]; Wei, Kecheng ^[2]; Wang, Qingxiao ^[3]; Kim, Moon J. ^[3]; ^[2]; ^[4]; ^[5]

Univ. of Central Florida, Orlando, FL (United States)
Brown Univ., Providence, RI (United States)
Univ. of Texas at Dallas, Richardson, TX (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
Univ. of Central Florida, Orlando, FL (United States); Univ. of Central Florida, Orlando, FL (United States). Nanoscience Technology Center

While nanoscale mimics of peroxidase have been extensively developed over the past decade or so, their catalytic efficiency as a key parameter has not been substantially improved in recent years. Herein, we report a class of highly efficient peroxidase mimic–nickel–platinum nanoparticles (Ni–Pt NPs) that consist of nickel-rich cores and platinum-rich shells. The Ni–Pt NPs exhibit a record high catalytic efficiency with a catalytic constant (K_cat) as high as 4.5 × 10⁷ s^–1, which is ~46- and 10⁴-fold greater than the K_cat values of conventional Pt nanoparticles and natural peroxidases, respectively. Density functional theory calculations reveal that the unique surface structure of Ni–Pt NPs weakens the adsorption of key intermediates during catalysis, which boosts the catalytic efficiency. Furthermore, the Ni–Pt NPs were applied to an immunoassay of a carcinoembryonic antigen that achieved an ultralow detection limit of 1.1 pg/mL, hundreds of times lower than that of the conventional enzyme-based assay.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: National Science Foundation (NSF); US Dept. of Agriculture; USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1766375

Journal Information:: Journal of the American Chemical Society, Journal Name: Journal of the American Chemical Society Journal Issue: 7 Vol. 143; ISSN 0002-7863

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Nickel–Platinum Nanoparticles as Peroxidase Mimics with a Record High Catalytic Efficiency

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