Supplemental microalgal astaxanthin produced coordinated changes in intrinsic antioxidant systems of layer hens exposed to heat stress

Magnuson, A. D.; Sun, T.; Yin, R.; Liu, G.; Tolba, S.; Shinde, S.; Lei, X. G.

doi:10.1016/j.algal.2018.04.031

Supplemental microalgal astaxanthin produced coordinated changes in intrinsic antioxidant systems of layer hens exposed to heat stress

Journal Article · Sun May 13 00:00:00 EDT 2018 · Algal Research

DOI:https://doi.org/10.1016/j.algal.2018.04.031· OSTI ID:2287681

Magnuson, A. D. ^[1]; Sun, T. ^[2]; Yin, R. ^[2]; Liu, G. ^[2]; Tolba, S. ^[2]; Shinde, S. ^[3]; Lei, X. G. ^[2]

Cornell University, Ithaca, NY (United States); Animal Science Department, Cornell University
Cornell University, Ithaca, NY (United States)
Heliae Development, Gilbert, AZ (United States)

Astaxanthin is a well-known antioxidant phytochemical that has limited bioavailability to humans. The present study was conducted to determine if microalgal astaxanthin was bioavailable to layer hens and affected antioxidant status of their tissues and eggs. A total of 50 White Leghorn Shavers (21-wk old) were divided into 5 groups (n = 10/group), caged individually in an environmentally-controlled room, and fed a corn-soybean meal basal diet supplemented with microalgal (Haematococcus pluvialis) astaxanthin (Heliae, Gibert, AZ) at 0, 10, 20, 40, and 80 mg/kg for 6 wk. Heat stress was induced during weeks 4–6 when the ambient temperature was raised 3 °C above the optimal temperature. Supplemental microalgal astaxanthin resulted in dose-dependent enrichments (P < 0.05) of astaxanthin and total carotenoids in the plasma and egg yolk of hens. The maximal concentrations of astaxanthin reached 4.1 μg/mL, 5.8 mg/kg, and 36 mg/kg, whereas those of total carotenoids reached 7.0 μg/mL, 75 mg/kg, and 114 mg/kg (on fresh tissue basis), respectively, in the plasma, liver, and egg yolk of hens. The oxygen radical absorbance capacity was also enhanced (P < 0.05) in a dose-dependent fashion in the liver and egg yolk of hens. Meanwhile, total glutathione concentration and activities of glutathione peroxidase and glutathione-S transferase in the liver of hens were decreased (P < 0.05) by the supplemental astaxanthin, compared with the control. Egg yolk color was changed (P < 0.05, more red) by the supplementation, and total PUFA concentration increased (P < 0.05) in the highest astaxanthin treatment group. As a result, supplemental dietary microalgal astaxanthin seemed to be highly bioavailable to be deposited in the plasma, liver, and eggs of hens, independent of heat stress, and resulted in coordinated changes in the intrinsic antioxidant systems.

View Accepted Manuscript (DOE)

Research Organization:: Duke University, Durham, NC (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: EE0007091

OSTI ID:: 2287681

Alternate ID(s):: OSTI ID: 1537951
OSTI ID: 1698123

Journal Information:: Algal Research, Journal Name: Algal Research Vol. 33; ISSN 2211-9264

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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