Soft tissue tumors among beagles injected with {sup 90}Sr, {sup 228}Ra, or {sup 228}Th
- Univ. of Utah, Salt Lake City, UT (United States); and others
The occurrence of soft-tissue tumors in beagles given {sup 90}Sr (88 dogs), {sup 228}Ra (76 dogs), or {sup 228}Th (81 dogs) as young adults and followed throughout their lifespans was compared with that of 133 control beagles given no radioactivity. For animals injected with {sup 228}Ra, tumors of the eye were more prominent (p<0.05) than in the controls, and soft-tissue tumors of cavities in the head (excluding the brain, mouth, and eye) were more prominent in dogs given {sup 90}Sr than in the controls (p<0.05). There was some indication that eye tumors in animals given about 0.56 kBq {sup 228}Th kg{sup {minus}1} were associated with their radionuclide exposure. For tumors at a few other locations, the relative occurrence was greater (p<0.05) in the controls. These included malignant tumors of the testis, and malignant plus benign tumors of the mammae and vagina in {sup 228}Ra dogs; and malignant plus benign tumors of the mammae in {sup 90}Sr dogs (p>0.05 by Odds Ratio Chi Square analysis but p<0.05 by Fiosher`s Exact Test). Differences in relative occurrence between radioactive dogs and controls of all other tumor types that appeared in any of the animals (notably lymphosarcoma, lymph node tumors, leukemia, mast cell tumors, liver tumors, etc.) were not statistically significant (p > 0.05). Intercurrent mortality, mainly from bone cancer, was higher in the radioactive dogs than in the controls. Mean survival was reduced in the dogs given {sup 90}Sr, {sup 228}Ra, or {sup 228}Th(13.17 {plus_minus} 2.64 y in controls, 10.95 {plus_minus} 4.06 y in {sup 90}Sr dogs, 9.07 {plus_minus} 3.61 y in {sup 228}Ra dogs, and 9.20 {plus_minus}4.15 y in {sup 228}Th dogs). Attenuated lifespans could account, at least in part, for the relative paucity of soft-tissue tumors not induced by radiation among the groups of dogs given radioactivity and occurring near the end of life for control animals. 24 refs., 3 tabs.
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-76EV00119; AC04-76EV01013
- OSTI ID:
- 166771
- Journal Information:
- Health Physics, Vol. 69, Issue 2; Other Information: PBD: Aug 1995
- Country of Publication:
- United States
- Language:
- English
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