skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Omics-Lethal Human Viruses, Influenza A Experiment IM102

Dataset ·
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [1]
  1. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
  2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
+ Show Author Affiliations

The purpose of this experiment was to evaluate the host response to wild-type Influenza A/Anhui/1/2013 (H7N9; "AH1-WT") virus and mutant viruses NS1-103F/106M ("AH1-F/M") and partially ferret-adapted ("AH1-691") infection. Sample data was obtained from mouse lung tissue and processed for mRNA, miRNA, proteomics, metabolomics, and lipidomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset download each have a direct relationship to a primary sample submission corresponding to a specific Influenza A virus infection.

Research Organization:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
Contributing Organization:
Modeling Host Responses to Understand Severe Human Virus Infections Program Project
DOE Contract Number:
AC05-76RL01830
OSTI ID:
1661918
Report Number(s):
IM102; NCBI BioProject: PRJNA284143 (mRNA); NCBI BioProject: PRJNA284146 (miRNA); GEO Series: GSE68945 (mRNA); GEO Series: GSE68946 (miRNA); MassIVE: MSV000079343 (proteome); MassIVE: MSV000079206 (metabolome); MassIVE: MSV000079542 (lipidome)
Availability:
rc-support@pnnl.gov
Country of Publication:
United States
Language:
English

References (1)

Hypergraph models of biological networks to identify genes critical to pathogenic viral response journal May 2021

Cited By (1)

PNNL DataHub Project Omics-LHV Profiling of Host Response to Influenza Infection Post-Processed Data Package DOIs dataset January 2021

Similar Records

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Virology [edam.topic:0781]
Immune Response [GO:0006955]
Mus musculus [NCBITAXON:10090]
Influenza A virus [NCBITAXON:11320]
Time Sampled Measurement Datasets [IAO:0000584]
Mass spectrometry data [edam.data:2536]
MassIVE dataset identifier [MS:1002487]
Gene expression profile data [edam.data:0928]
BioProject Accession Number [NCIT:C175890]
Omics [edam.topic:3391]
Multi-omics [edam.topic:4021]
data transformation [SIO:000594]
differential expression analysis [SWO:7000018]
Data Download [schema:DataDownload]