Omics-Lethal Human Viruses, Influenza A Experiment ICL103
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
The purpose of this experiment was to evaluate the human host response to Influenza A wild-type (H5N1) virus and mutant viruses. Sample data was obtained for human lung adenocarcinoma cell line (Calu-3) infected with WT Influenza A/Vietnam/1203/2004 (H5N1, VN1203) and mutant viruses PB2-K627E and NS1-trunc124 for mRNA, miRNA, proteomics, lipidomics, and metabolomics data analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset download each have a direct relationship to a primary sample submission corresponding to a specific Influenza A virus infection.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
- Contributing Organization:
- Modeling Host Responses to Understand Severe Human Virus Infections Program Project
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1661913
- Report Number(s):
- ICL103; NCBI BioProject: PRJNA308121; GEO Series: GSE76599 (mRNA); GEO Series: GSE76600 (miRNA); MassIVE: MSV000079459 (proteome); MassIVE: MSV000079460 (metabolome); MassIVE: MSV000080023 (lipidome)
- Availability:
- rc-support@pnnl.gov
- Country of Publication:
- United States
- Language:
- English
Hypergraph models of biological networks to identify genes critical to pathogenic viral response
|
journal | May 2021 |
PNNL DataHub Project Omics-LHV Profiling of Host Response to Influenza Infection Post-Processed Data Package DOIs
|
dataset | January 2021 |
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Omics-Lethal Human Viruses, Influenza A Experiment IM103
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Related Subjects
Virology [edam.topic:0781]
Immune Response [GO:0006955]
Human virus [NCIT:C14317]
Influenza A virus [NCBITAXON:11320]
Time Sampled Measurement Datasets [IAO:0000584]
Mass spectrometry data [edam.data:2536]
MassIVE dataset identifier [MS:1002487]
Gene expression profile data [edam.data:0928]
BioProject Accession Number [NCIT:C175890]
Omics [edam.topic:3391]
Multi-omics [edam.topic:4021]
data transformation [SIO:000594]
differential expression analysis [SWO:7000018]
Data Download [schema:DataDownload]