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Omics-Lethal Human Viruses, Influenza A Experiment ICL104

Dataset ·
 [1];  [2];  [3]
  1. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Pacific Northwest National Laboratory, Biological Sciences Division
  2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
  3. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
+ Show Author Affiliations

The purpose of this experiment was to evaluate the host response to Influenza A pandemic wild-type H1N1 (A/California/04/2009), natural isolate virus. Sample data was obtained from human lung adenocarcinoma cells (Calu-3) with wild-type H1N1 virus (A/California/04/2009) and processed for mRNA, miRNA, proteomics, metabolomics, and lipidomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset download each have a direct relationship to a primary sample submission corresponding to a specific Influenza A virus infection.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
Contributing Organization:
Modeling Host Responses to Understand Severe Human Virus Infections Program Project
DOE Contract Number:
AC05-76RL01830
OSTI ID:
1661914
Report Number(s):
ICL104; NCBI BioProject: PRJNA319727; GEO Series: GSE80697 (mRNA); GEO Series: GSE80698 (miRNA); MassIVE: MSV000080026 (proteome); MassIVE: MSV000079704 (metabolome); MassIVE: MSV000081049 (lipidome)
Availability:
rc-support@pnnl.gov
Country of Publication:
United States
Language:
English

References (1)

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape journal January 2018

Cited By (1)

PNNL DataHub Project Omics-LHV Profiling of Host Response to Influenza Infection Post-Processed Data Package DOIs dataset January 2021

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BioProject Accession Number [NCIT:C175890]
Data Download [schema:DataDownload]
Gene expression profile data [edam.data:0928]
Human virus [NCIT:C14317]
Immune Response [GO:0006955]
Influenza A virus [NCBITAXON:11320]
Mass spectrometry data [edam.data:2536]
MassIVE dataset identifier [MS:1002487]
Multi-omics [edam.topic:4021]
Omics [edam.topic:3391]
Time Sampled Measurement Datasets [IAO:0000584]
Virology [edam.topic:0781]
data transformation [SIO:000594]
differential expression analysis [SWO:7000018]