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Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat

Journal Article · · Science Advances
 [1];  [1];  [2];  [2];  [3];  [2];  [3];  [4];  [5];  [5];  [2];  [3];  [2];  [5];  [1];  [2];  [1]
  1. Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences and Berkeley Sensor and Actuator Center; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
  2. VTT-Technical Research Centre of Finland, Oulu (Finland)
  3. Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences
  4. Univ. of California, Berkeley, CA (United States). California Inst. for Quantitative Biosciences (QB3)
  5. Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
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Recent technological advancements in wearable sensors have made it easier to detect sweat components, but our limited understanding of sweat restricts its application. A critical bottleneck for temporal and regional sweat analysis is achieving uniform, high-throughput fabrication of sweat sensor components, including microfluidic chip and sensing electrodes. To overcome this challenge, we introduce microfluidic sensing patches mass fabricated via roll-to-roll (R2R) processes. The patch allows sweat capture within a spiral microfluidic for real-time measurement of sweat parameters including [Na+], [K+], [glucose], and sweat rate in exercise and chemically induced sweat. The patch is demonstrated for investigating regional sweat composition, predicting whole-body fluid/electrolyte loss during exercise, uncovering relationships between sweat metrics, and tracking glucose dynamics to explore sweat-to-blood correlations in healthy and diabetic individuals. By enabling a comprehensive sweat analysis, the presented device is a crucial tool for advancing sweat testing beyond the research stage for point-of-care medical and athletic applications.
Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
1638993
Journal Information:
Science Advances, Journal Name: Science Advances Journal Issue: 8 Vol. 5; ISSN 2375-2548
Publisher:
AAASCopyright Statement
Country of Publication:
United States
Language:
English

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Resettable skin interfaced microfluidic sweat collection devices with chemesthetic hydration feedback journal December 2019
Effect of Electrode Modification with Chitosan and Nafion® on the Efficiency of Real-Time Enzyme Glucose Biosensors Based on ZnO Tetrapods journal July 2022
Soft Wearable Systems for Colorimetric and Electrochemical Analysis of Biofluids journal December 2019
A Mediator‐Free Electroenzymatic Sensing Methodology to Mitigate Ionic and Electroactive Interferents' Effects for Reliable Wearable Metabolite and Nutrient Monitoring journal December 2019
Ultra-simple wearable local sweat volume monitoring patch based on swellable hydrogels journal January 2020
Wearable flexible sweat sensors for healthcare monitoring: a review journal October 2019

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