Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat

doi:https://doi.org/10.1126/sciadv.aaw9906

Title: Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat

Abstract

Recent technological advancements in wearable sensors have made it easier to detect sweat components, but our limited understanding of sweat restricts its application. A critical bottleneck for temporal and regional sweat analysis is achieving uniform, high-throughput fabrication of sweat sensor components, including microfluidic chip and sensing electrodes. To overcome this challenge, we introduce microfluidic sensing patches mass fabricated via roll-to-roll (R2R) processes. The patch allows sweat capture within a spiral microfluidic for real-time measurement of sweat parameters including [Na ⁺], [K ⁺], [glucose], and sweat rate in exercise and chemically induced sweat. The patch is demonstrated for investigating regional sweat composition, predicting whole-body fluid/electrolyte loss during exercise, uncovering relationships between sweat metrics, and tracking glucose dynamics to explore sweat-to-blood correlations in healthy and diabetic individuals. By enabling a comprehensive sweat analysis, the presented device is a crucial tool for advancing sweat testing beyond the research stage for point-of-care medical and athletic applications.

Authors:

^[1];

^[2]; Uusitalo, Sanna ^[2];

^[3]; Jansson, Elina ^[2];

^[3];

^[4]; Zhao, Jiangqi ^[5]; Lin, Yuanjing ^[5];

^[2]; Chao, Minghan ^[3];

^[2];

^[5]; Tai, Li-Chia ^[1]; Hiltunen, Jussi ^[2];

^[1]

Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences and Berkeley Sensor and Actuator Center; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
VTT-Technical Research Centre of Finland, Oulu (Finland)
Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences
Univ. of California, Berkeley, CA (United States). California Inst. for Quantitative Biosciences (QB3)
Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division

Publication Date:: 2019-08-16

Research Org.:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; National Science Foundation (NSF)

OSTI Identifier:: 1638993

Grant/Contract Number:: AC02-05CH11231

Resource Type:: Journal Article: Accepted Manuscript

Journal Name:: Science Advances

Additional Journal Information:: Journal Volume: 5; Journal Issue: 8; Journal ID: ISSN 2375-2548

Publisher:: AAAS

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Nyein, Hnin Yin Yin, Bariya, Mallika, Kivimäki, Liisa, Uusitalo, Sanna, Liaw, Tiffany Sun, Jansson, Elina, Ahn, Christine Heera, Hangasky, John A., Zhao, Jiangqi, Lin, Yuanjing, Happonen, Tuomas, Chao, Minghan, Liedert, Christina, Zhao, Yingbo, Tai, Li-Chia, Hiltunen, Jussi, and Javey, Ali. Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat.  United States: N. p., 2019. 
        Web.  doi:10.1126/sciadv.aaw9906.

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                    Nyein, Hnin Yin Yin, Bariya, Mallika, Kivimäki, Liisa, Uusitalo, Sanna, Liaw, Tiffany Sun, Jansson, Elina, Ahn, Christine Heera, Hangasky, John A., Zhao, Jiangqi, Lin, Yuanjing, Happonen, Tuomas, Chao, Minghan, Liedert, Christina, Zhao, Yingbo, Tai, Li-Chia, Hiltunen, Jussi, & Javey, Ali. Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat.  United States.  https://doi.org/10.1126/sciadv.aaw9906

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                    Nyein, Hnin Yin Yin, Bariya, Mallika, Kivimäki, Liisa, Uusitalo, Sanna, Liaw, Tiffany Sun, Jansson, Elina, Ahn, Christine Heera, Hangasky, John A., Zhao, Jiangqi, Lin, Yuanjing, Happonen, Tuomas, Chao, Minghan, Liedert, Christina, Zhao, Yingbo, Tai, Li-Chia, Hiltunen, Jussi, and Javey, Ali. Fri .  
        "Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat".  United States.  https://doi.org/10.1126/sciadv.aaw9906.  https://www.osti.gov/servlets/purl/1638993.

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@article{osti_1638993,

  title        = {Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat},

  author       = {Nyein, Hnin Yin Yin and Bariya, Mallika and Kivimäki, Liisa and Uusitalo, Sanna and Liaw, Tiffany Sun and Jansson, Elina and Ahn, Christine Heera and Hangasky, John A. and Zhao, Jiangqi and Lin, Yuanjing and Happonen, Tuomas and Chao, Minghan and Liedert, Christina and Zhao, Yingbo and Tai, Li-Chia and Hiltunen, Jussi and Javey, Ali},

  abstractNote = {Recent technological advancements in wearable sensors have made it easier to detect sweat components, but our limited understanding of sweat restricts its application. A critical bottleneck for temporal and regional sweat analysis is achieving uniform, high-throughput fabrication of sweat sensor components, including microfluidic chip and sensing electrodes. To overcome this challenge, we introduce microfluidic sensing patches mass fabricated via roll-to-roll (R2R) processes. The patch allows sweat capture within a spiral microfluidic for real-time measurement of sweat parameters including [Na+], [K+], [glucose], and sweat rate in exercise and chemically induced sweat. The patch is demonstrated for investigating regional sweat composition, predicting whole-body fluid/electrolyte loss during exercise, uncovering relationships between sweat metrics, and tracking glucose dynamics to explore sweat-to-blood correlations in healthy and diabetic individuals. By enabling a comprehensive sweat analysis, the presented device is a crucial tool for advancing sweat testing beyond the research stage for point-of-care medical and athletic applications.},

  doi          = {10.1126/sciadv.aaw9906},

  url          = {https://www.osti.gov/biblio/1638993},
  journal      = {Science Advances},

  issn         = {2375-2548},

  number       = 8,

  volume       = 5,

  place        = {United States},

  year         = {2019},

  month        = {8}

}

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Similar Records

Title: Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat

Abstract

Citation Formats

The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications journal, May 2015

Sweat testing to evaluate autonomic function journal, November 2008

Whole body sweat collection in humans: an improved method with preliminary data on electrolyte content journal, January 1997

An ultra-lightweight design for imperceptible plastic electronics journal, July 2013

Roll-to-roll fabrication of integrated PDMS–paper microfluidics for nucleic acid amplification journal, January 2018

Nitrogen Excretion in Sweat and Its Relation to Nitrogen Balance Requirements journal, April 1963

Enhancing glucose flux into sweat by increasing paracellular permeability of the sweat gland journal, July 2018

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis journal, January 2016

Multifunctional Wearable System that Integrates Sweat-Based Sensing and Vital-Sign Monitoring to Estimate Pre-/Post-Exercise Glucose Levels journal, October 2018

Challenges and opportunities in wearable technology for biochemical analysis in sweat journal, June 2017

Roll-to-Roll Gravure Printed Electrochemical Sensors for Wearable and Medical Devices journal, June 2018

Elevated Neuroimmune Biomarkers in Sweat Patches and Plasma of Premenopausal Women with Major Depressive Disorder in Remission: The POWER Study journal, November 2008

Heat cramps: fluid and electrolyte challenges during tennis in the heat journal, March 2003

Inexpensive, rapid prototyping of microfluidic devices using overhead transparencies and a laser print, cut and laminate fabrication method journal, May 2015

Lactate in human sweat: a critical review of research to the present day journal, June 2012

Chemical Composition of Sweat journal, April 1954

Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology journal, March 2017

A wearable chemical–electrophysiological hybrid biosensing system for real-time health and fitness monitoring journal, May 2016

Sweating Rate and Sweat Sodium Concentration in Athletes: A Review of Methodology and Intra/Interindividual Variability journal, March 2017

Screen printed passive components for flexible power electronics journal, October 2015

Skin-interfaced systems for sweat collection and analytics journal, February 2018

Asymmetric sweating in stroke: A prospective quantitative study of patients with hemispheral brain infarction journal, June 1993

A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy journal, March 2016

Neural control and mechanisms of eccrine sweating during heat stress and exercise journal, May 2006

A wearable pH sensor with high sensitivity based on a flexible charge-coupled device journal, November 2018

Skin electronics from scalable fabrication of an intrinsically stretchable transistor array journal, February 2018

Highly ordered nanowire arrays on plastic substrates for ultrasensitive flexible chemical sensors journal, April 2007

Technologies for Printing Sensors and Electronics Over Large Flexible Substrates: A Review journal, June 2015

Regional variations in transepidermal water loss, eccrine sweat gland density, sweat secretion rates and electrolyte composition in resting and exercising humans journal, February 2013

Correlation Between Sweat Glucose and Blood Glucose in Subjects with Diabetes journal, May 2012

A Wearable Microfluidic Sensing Patch for Dynamic Sweat Secretion Analysis journal, May 2018

Dermcidin: a novel human antibiotic peptide secreted by sweat glands journal, November 2001

Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System journal, July 2016

Portable biosensor for monitoring cortisol in low-volume perspired human sweat journal, October 2017

Wearable non-invasive epidermal glucose sensors: A review journal, January 2018

Excretion of Sodium and Potassium in Human Sweat 1 journal, January 1956

Methylxanthine Drug Monitoring with Wearable Sweat Sensors journal, April 2018

‘SWEATCH’: A Wearable Platform for Harvesting and Analysing Sweat Sodium Content journal, April 2016

Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform journal, April 2017

Complete validation of a continuous and blood-correlated sweat biosensing device with integrated sweat stimulation journal, January 2018

Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat journal, January 2019

A Sweat-Patch Test for Alcohol Consumption: Evaluation in Continuous and Episodic Drinkers journal, October 1980

Microfluidic channels laser-cut in thin double-sided tapes: Cost-effective biocompatible fluidics in minutes from design to final integration with optical biochips journal, June 2014

Wearable and flexible electronics for continuous molecular monitoring journal, January 2019

Ultralight and Binder-Free All-Solid-State Flexible Supercapacitors for Powering Wearable Strain Sensors journal, August 2017

Body map of regional vs. whole body sweating rate and sweat electrolyte concentrations in men and women during moderate exercise-heat stress journal, May 2018

Wearable flexible sweat sensors for healthcare monitoring: a review journal, October 2019

Soft Wearable Systems for Colorimetric and Electrochemical Analysis of Biofluids journal, December 2019

Ultra-simple wearable local sweat volume monitoring patch based on swellable hydrogels journal, January 2020

Resettable skin interfaced microfluidic sweat collection devices with chemesthetic hydration feedback journal, December 2019

A Mediator‐Free Electroenzymatic Sensing Methodology to Mitigate Ionic and Electroactive Interferents' Effects for Reliable Wearable Metabolite and Nutrient Monitoring journal, December 2019

The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications
journal, May 2015

Sweat testing to evaluate autonomic function
journal, November 2008

Whole body sweat collection in humans: an improved method with preliminary data on electrolyte content
journal, January 1997

An ultra-lightweight design for imperceptible plastic electronics
journal, July 2013

Roll-to-roll fabrication of integrated PDMS–paper microfluidics for nucleic acid amplification
journal, January 2018

Nitrogen Excretion in Sweat and Its Relation to Nitrogen Balance Requirements
journal, April 1963

Enhancing glucose flux into sweat by increasing paracellular permeability of the sweat gland
journal, July 2018

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
journal, January 2016

Multifunctional Wearable System that Integrates Sweat-Based Sensing and Vital-Sign Monitoring to Estimate Pre-/Post-Exercise Glucose Levels
journal, October 2018

Challenges and opportunities in wearable technology for biochemical analysis in sweat
journal, June 2017

Roll-to-Roll Gravure Printed Electrochemical Sensors for Wearable and Medical Devices
journal, June 2018

Elevated Neuroimmune Biomarkers in Sweat Patches and Plasma of Premenopausal Women with Major Depressive Disorder in Remission: The POWER Study
journal, November 2008

Heat cramps: fluid and electrolyte challenges during tennis in the heat
journal, March 2003

Inexpensive, rapid prototyping of microfluidic devices using overhead transparencies and a laser print, cut and laminate fabrication method
journal, May 2015

Lactate in human sweat: a critical review of research to the present day
journal, June 2012

Chemical Composition of Sweat
journal, April 1954

Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology
journal, March 2017

A wearable chemical–electrophysiological hybrid biosensing system for real-time health and fitness monitoring
journal, May 2016

Sweating Rate and Sweat Sodium Concentration in Athletes: A Review of Methodology and Intra/Interindividual Variability
journal, March 2017

Screen printed passive components for flexible power electronics
journal, October 2015

Skin-interfaced systems for sweat collection and analytics
journal, February 2018

Asymmetric sweating in stroke: A prospective quantitative study of patients with hemispheral brain infarction
journal, June 1993

A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
journal, March 2016

Neural control and mechanisms of eccrine sweating during heat stress and exercise
journal, May 2006

A wearable pH sensor with high sensitivity based on a flexible charge-coupled device
journal, November 2018

Skin electronics from scalable fabrication of an intrinsically stretchable transistor array
journal, February 2018

Highly ordered nanowire arrays on plastic substrates for ultrasensitive flexible chemical sensors
journal, April 2007

Technologies for Printing Sensors and Electronics Over Large Flexible Substrates: A Review
journal, June 2015

Regional variations in transepidermal water loss, eccrine sweat gland density, sweat secretion rates and electrolyte composition in resting and exercising humans
journal, February 2013

Correlation Between Sweat Glucose and Blood Glucose in Subjects with Diabetes
journal, May 2012

A Wearable Microfluidic Sensing Patch for Dynamic Sweat Secretion Analysis
journal, May 2018

Dermcidin: a novel human antibiotic peptide secreted by sweat glands
journal, November 2001

Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System
journal, July 2016

Portable biosensor for monitoring cortisol in low-volume perspired human sweat
journal, October 2017

Wearable non-invasive epidermal glucose sensors: A review
journal, January 2018

Excretion of Sodium and Potassium in Human Sweat 1
journal, January 1956

Methylxanthine Drug Monitoring with Wearable Sweat Sensors
journal, April 2018

‘SWEATCH’: A Wearable Platform for Harvesting and Analysing Sweat Sodium Content
journal, April 2016

Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform
journal, April 2017

Complete validation of a continuous and blood-correlated sweat biosensing device with integrated sweat stimulation
journal, January 2018

Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat
journal, January 2019

A Sweat-Patch Test for Alcohol Consumption: Evaluation in Continuous and Episodic Drinkers
journal, October 1980

Microfluidic channels laser-cut in thin double-sided tapes: Cost-effective biocompatible fluidics in minutes from design to final integration with optical biochips
journal, June 2014

Wearable and flexible electronics for continuous molecular monitoring
journal, January 2019

Ultralight and Binder-Free All-Solid-State Flexible Supercapacitors for Powering Wearable Strain Sensors
journal, August 2017

Body map of regional vs. whole body sweating rate and sweat electrolyte concentrations in men and women during moderate exercise-heat stress
journal, May 2018

Wearable flexible sweat sensors for healthcare monitoring: a review
journal, October 2019

Soft Wearable Systems for Colorimetric and Electrochemical Analysis of Biofluids
journal, December 2019

Ultra-simple wearable local sweat volume monitoring patch based on swellable hydrogels
journal, January 2020

Resettable skin interfaced microfluidic sweat collection devices with chemesthetic hydration feedback
journal, December 2019

A Mediator‐Free Electroenzymatic Sensing Methodology to Mitigate Ionic and Electroactive Interferents' Effects for Reliable Wearable Metabolite and Nutrient Monitoring
journal, December 2019