A Wearable Microfluidic Sensing Patch for Dynamic Sweat Secretion Analysis

Nyein, Hnin Yin Yin; Tai, Li-Chia; Ngo, Quynh Phuong; Chao, Minghan; Zhang, George B.; Gao, Wei; Bariya, Mallika; Bullock, James; Kim, Hyungjin; Fahad, Hossain M.; Javey, Ali

doi:10.1021/acssensors.7b00961

A Wearable Microfluidic Sensing Patch for Dynamic Sweat Secretion Analysis

Journal Article · Wed May 09 00:00:00 EDT 2018 · ACS Sensors

DOI:https://doi.org/10.1021/acssensors.7b00961· OSTI ID:1638976

^[1]; Tai, Li-Chia ^[1]; Ngo, Quynh Phuong ^[2]; Chao, Minghan ^[3]; Zhang, George B. ^[2]; Gao, Wei ^[1]; Bariya, Mallika ^[1]; ^[1]; Kim, Hyungjin ^[1]; ^[4]; ^[1]

Univ. of California, Berkeley, CA (United States). Dept. of Materials Science and Engineering and Berkeley Sensor and Actuator Center; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
Univ. of California, Berkeley, CA (United States). Dept. of Materials Science and Engineering; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
Univ. of California, Berkeley, CA (United States). Dept. of Materials Science and Engineering
Univ. of California, Berkeley, CA (United States). Dept. of Materials Science and Engineering and Berkeley Sensor and Actuator Center

Wearable sweat sensing is a rapidly rising research area driven by its promising potential in health, fitness, and diagnostic applications. Despite the growth in the field, major challenges in relation to sweat metrics remain to be addressed. These challenges include sweat rate monitoring for its complex relation with sweat compositions and sweat sampling for sweat dynamics studies. Here, we present a flexible microfluidic sweat sensing patch that enhances real-time electrochemical sensing and sweat rate analysis via sweat sampling. The device contains a spiral-patterned microfluidic component that is embedded with ion-selective sensors and an electrical impedance-based sweat rate sensor on a flexible plastic substrate. The patch is enabled to autonomously perform sweat analysis by interfacing the sensing component with a printed circuit board that is capable of on-site signal conditioning, analysis, and transmission. Progressive sweat flow in the microfluidic device, governed by the pressure induced by the secreted sweat, enhances sweat sampling and electrochemical detection via a defined sweat collection chamber and a directed sweat route. The characteristic of the sweat rate sensor is validated through a theoretical simulation, and the precision and accuracy of the flow rate is verified with a commercial syringe pump and a Macroduct sweat collector. On-body simultaneous monitoring of ion (H⁺, Na⁺, K⁺, Cl^–) concentration and sweat rate is also demonstrated for sensor functionality. This sweat sensing patch provides an integrated platform for a comprehensive sweat secretion analysis and facilitates physiological and clinical investigations by closely monitoring interrelated sweat parameters.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1638976

Journal Information:: ACS Sensors, Journal Name: ACS Sensors Journal Issue: 5 Vol. 3; ISSN 2379-3694

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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