Butyric acid: Applications and recent advances in its bioproduction

Jiang, Ling; Fu, Hongxin; Yang, Hopen K.; Xu, Wei; Wang, Jufang; Yang, Shang-Tian

doi:10.1016/j.biotechadv.2018.09.005

Butyric acid: Applications and recent advances in its bioproduction

Journal Article · Wed Sep 26 00:00:00 EDT 2018 · Biotechnology Advances

DOI:https://doi.org/10.1016/j.biotechadv.2018.09.005· OSTI ID:1613553

^[1]; Fu, Hongxin ^[2]; Yang, Hopen K. ^[3]; Xu, Wei ^[4]; ^[5]; ^[3]

South China University of Technology, Guangzhou (China); Nanjing Tech University (China); DOE/OSTI
South China University of Technology, Guangzhou (China)
The Ohio State Univ., Columbus, OH (United States)
The Ohio State Univ., Columbus, OH (United States); Yancheng Institute of Technology, Yancheng (China)
The Ohio State Univ., Columbus, OH (United States); Univ. of South Carolina, Columbia, SC (United States)

Butyric acid is an important C4 organic acid with broad applications. It is currently produced by chemosynthesis from petroleum-based feedstocks. However, the fermentative production of butyric acid from renewable feedstocks has received growing attention because of consumer demand for green products and natural ingredients in foods, pharmaceuticals, animal feed supplements, and cosmetics. In this review, strategies for improving microbial butyric acid production, including strain engineering and novel fermentation process development are discussed and compared regarding product yield, titer, purity and productivity. Future perspectives on strain and process improvements for butyric acid production are also discussed.

View Accepted Manuscript (DOE)

Research Organization:: The Ohio State University, Columbus, OH (United States)

Sponsoring Organization:: USDOE Advanced Research Projects Agency - Energy (ARPA-E)

Grant/Contract Number:: AR0000095; EE0007005

OSTI ID:: 1613553

Alternate ID(s):: OSTI ID: 1636860

Journal Information:: Biotechnology Advances, Journal Name: Biotechnology Advances Journal Issue: 8 Vol. 36; ISSN 0734-9750

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

References (171)

Prodrugs of butyric acid from bench to bedside: Synthetic design, mechanisms of action, and clinical applications Rephaeli, Ada; Zhuk, Regina; Nudelman, Abraham Drug Development Research, Vol. 50, Issue 3-4 https://doi.org/10.1002/1098-2299(200007/08)50:3/4<379::AID-DDR20>3.0.CO;2-8	journal	January 2000
Metabolic engineering of clostridia for the production of chemicals Cho, Changhee; Jang, Yu-Sin; Moon, Hyeon Gi Biofuels, Bioproducts and Biorefining, Vol. 9, Issue 2 https://doi.org/10.1002/bbb.1531	journal	December 2014
Extractive fermentation for butyric acid production from glucose byClostridium tyrobutyricum Wu, Zetang; Yang, Shang-Tian Biotechnology and Bioengineering, Vol. 82, Issue 1 https://doi.org/10.1002/bit.10542	journal	February 2003
Restructuring upstream bioprocessing: technological and economical aspects for production of a generic microbial feedstock from wheat Koutinas, A. A.; Wang, R.; Webb, C. Biotechnology and Bioengineering, Vol. 85, Issue 5 https://doi.org/10.1002/bit.10888	journal	January 2004
Construction and characterization ofpta gene-deleted mutant ofClostridium tyrobutyricum for enhanced butyric acid fermentation Zhu, Ying; Liu, Xiaoguang; Yang, Shang-Tian Biotechnology and Bioengineering, Vol. 90, Issue 2 https://doi.org/10.1002/bit.20354	journal	January 2005
Enhanced butyric acid tolerance and bioproduction by Clostridium tyrobutyricum immobilized in a fibrous bed bioreactor Jiang, Ling; Wang, Jufang; Liang, Shizhong Biotechnology and Bioengineering, Vol. 108, Issue 1 https://doi.org/10.1002/bit.22927	journal	October 2010
Adaptive evolution for fast growth on glucose and the effects on the regulation of glucose transport system in Clostridium tyrobutyricum Jiang, Ling; Li, Shuang; Hu, Yi Biotechnology and Bioengineering, Vol. 109, Issue 3 https://doi.org/10.1002/bit.23346	journal	December 2011
Butyrate production enhancement by Clostridium tyrobutyricum using electron mediators and a cathodic electron donor Choi, Okkyoung; Um, Youngsoon; Sang, Byoung-In Biotechnology and Bioengineering, Vol. 109, Issue 10 https://doi.org/10.1002/bit.24520	journal	April 2012
Physiological response of Clostridium carboxidivorans during conversion of synthesis gas to solvents in a gas-fed bioreactor Ukpong, Michael N.; Atiyeh, Hasan K.; De Lorme, Marthah J. M. Biotechnology and Bioengineering, Vol. 109, Issue 11 https://doi.org/10.1002/bit.24549	journal	May 2012
Butyrate production in engineered Escherichia coli with synthetic scaffolds: Butyrate Production in Engineered Escherichia coli Baek, Jang-Mi; Mazumdar, Suman; Lee, Sang-Woo Biotechnology and Bioengineering, Vol. 110, Issue 10 https://doi.org/10.1002/bit.24925	journal	April 2013
Demonstration of in situ product recovery of butyric acid via CO ₂ -facilitated pH swings and medium development in two-phase partitioning bioreactors: In Situ Product Recovery of Butyric Acid using CO ₂ Peterson, Eric C.; Daugulis, Andrew J. Biotechnology and Bioengineering, Vol. 111, Issue 3 https://doi.org/10.1002/bit.25106	journal	September 2013
The use of high pressure CO ₂ -facilitated pH swings to enhance in situ product recovery of butyric acid in a two-phase partitioning bioreactor: Polymeric Online Recovery of Butyric Acid Peterson, Eric C.; Daugulis, Andrew J. Biotechnology and Bioengineering, Vol. 111, Issue 11 https://doi.org/10.1002/bit.25285	journal	September 2014
High cell density propionic acid fermentation with an acid tolerant strain of Propionibacterium acidipropionici : High Cell Density Propionic Acid Fermentation Wang, Zhongqiang; Jin, Ying; Yang, Shang-Tian Biotechnology and Bioengineering, Vol. 112, Issue 3 https://doi.org/10.1002/bit.25466	journal	October 2014
Effects of ptb knockout on butyric acid fermentation by Clostridium tyrobutyricum Zhang, Yali; Yu, Mingrui; Yang, Shang-Tian Biotechnology Progress, Vol. 28, Issue 1 https://doi.org/10.1002/btpr.730	journal	October 2011
Membrane fouling caused by amino acid and calcium during bipolar membrane electrodialysis Ren, Hongyan; Wang, Qian; Zhang, Xiaoyan Journal of Chemical Technology & Biotechnology, Vol. 83, Issue 11 https://doi.org/10.1002/jctb.1969	journal	October 2008
Long-term production of butyric acid through immobilization of Clostridium tyrobutyricum in a moving fibrous-bed bioreactor (MFBB): Production of butyric acid via immobilization of C. tyrobutyricum in MFBB Shi, Zhouming; Huang, Lei; Wu, Xiangting Journal of Chemical Technology & Biotechnology, Vol. 89, Issue 12 https://doi.org/10.1002/jctb.4271	journal	March 2014
Butyric acid production from recycled waste paper by immobilized Clostridium tyrobutyricum in a fibrous-bed bioreactor: Butyric acid production from waste paper by immobilized C. tyrobutyricum Huang, Jin; Dai, Hongliang; Yan, Ren Journal of Chemical Technology & Biotechnology, Vol. 91, Issue 4 https://doi.org/10.1002/jctb.4680	journal	April 2015
The effect of furfural and 5‐hydroxymethyl furfural on butyric acid fermentation by Clostridium tyrobutyricum Liu, Ying; Geng, Yingxi; Zhou, Quan Journal of Chemical Technology & Biotechnology, Vol. 93, Issue 3 https://doi.org/10.1002/jctb.5439	journal	October 2017
Effect of growth supplements and whey pretreatment on butyric acid production by Clostridium butyricum Vandák, D.; Tomáška, M.; Zigová, J. World Journal of Microbiology & Biotechnology, Vol. 11, Issue 3 https://doi.org/10.1007/BF00367124	journal	May 1995
Growth and butyric acid production by Clostridium populeti Patel, G. B.; Agnew, B. J. Archives of Microbiology, Vol. 150, Issue 3 https://doi.org/10.1007/BF00407790	journal	July 1988
Fermentation of cheese whey by a mixed culture ofClostridium beijerinckii andBacillus cereus Stevens, David; Alam, Shahriar; Bajpai, Rakesh Journal of Industrial Microbiology, Vol. 3, Issue 1 https://doi.org/10.1007/BF01569437	journal	February 1988
Production of butyric acid by batch fermentation of cheese whey withClostridium beijerinckii Alam, Shahriar; Stevens, David; Bajpai, Rakesh Journal of Industrial Microbiology, Vol. 2, Issue 6 https://doi.org/10.1007/BF01569574	journal	January 1988
Fermentation of raw glycerol to 1,3-propanediol by new strains ofClostridium butyricum Petitdemange, E.; Dürr, C.; Andaloussi, S. Abbad Journal of Industrial Microbiology, Vol. 15, Issue 6 https://doi.org/10.1007/BF01570021	journal	December 1995
Effect of controlled substrate feeding on butyric acid production byClostridium tyrobutyricum Fayolle, Françoise; Marchal, Rémy; Ballerini, Daniel Journal of Industrial Microbiology, Vol. 6, Issue 3 https://doi.org/10.1007/BF01577693	journal	November 1990
Glucose fermentation byClostridium butyricum grown under a self generated gas atmosphere in chemostat culture van Andel, J. G.; Zoutberg, G. R.; Crabbendam, P. M. Applied Microbiology and Biotechnology, Vol. 23, Issue 1 https://doi.org/10.1007/BF02660113	journal	November 1985
Butyrate production from carbon monoxide byButyribacterium methylotrophicum Worden, R. M.; Grethlein, A. J.; Zeikus, J. G. Applied Biochemistry and Biotechnology, Vol. 20-21, Issue 1 https://doi.org/10.1007/BF02936517	journal	January 1989
Effects of different replicons in conjugative plasmids on transformation efficiency, plasmid stability, gene expression and n-butanol biosynthesis in Clostridium tyrobutyricum Yu, Mingrui; Du, Yinming; Jiang, Wenyan Applied Microbiology and Biotechnology, Vol. 93, Issue 2 https://doi.org/10.1007/s00253-011-3736-y	journal	December 2011
Metabolic engineering of Clostridium acetobutylicum for enhanced production of butyric acid Jang, Yu-Sin; Woo, Hee Moon; Im, Jung Ae Applied Microbiology and Biotechnology, Vol. 97, Issue 21 https://doi.org/10.1007/s00253-013-5161-x	journal	September 2013
Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production with high butyrate/acetate ratio Suo, Yukai; Ren, Mengmeng; Yang, Xitong Applied Microbiology and Biotechnology, Vol. 102, Issue 10 https://doi.org/10.1007/s00253-018-8954-0	journal	April 2018
Current Progress on Butyric Acid Production by Fermentation Zhang, Chunhui; Yang, Hua; Yang, Fangxiao Current Microbiology, Vol. 59, Issue 6 https://doi.org/10.1007/s00284-009-9491-y	journal	August 2009
Hyper-thermal acid hydrolysis and adsorption treatment of red seaweed, Gelidium amansii for butyric acid production with pH control Ra, Chae Hun; Jeong, Gwi-Taek; Kim, Sung-Koo Bioprocess and Biosystems Engineering, Vol. 40, Issue 3 https://doi.org/10.1007/s00449-016-1708-4	journal	November 2016
Insights from the complete genome sequence of Clostridium tyrobutyricum provide a platform for biotechnological and industrial applications Wu, Qian; Liu, Tingting; Zhu, Liying Journal of Industrial Microbiology and Biotechnology, Vol. 44, Issue 8 https://doi.org/10.1007/s10295-017-1956-6	journal	August 2017
Butyric acid production from red algae by a newly isolated Clostridium sp. S1 Lee, Kyung Min; Choi, Okkyoung; Kim, Ki-Yeon Biotechnology Letters, Vol. 37, Issue 9 https://doi.org/10.1007/s10529-015-1869-2	journal	May 2015
Revisit dietary fiber on colorectal cancer: butyrate and its role on prevention and treatment Encarnação, J. C.; Abrantes, A. M.; Pires, A. S. Cancer and Metastasis Reviews, Vol. 34, Issue 3 https://doi.org/10.1007/s10555-015-9578-9	journal	July 2015
High production of butyric acid by Clostridium tyrobutyricum mutant Ma, Chao; Ou, Jianfa; Miller, Matthew Frontiers of Chemical Science and Engineering, Vol. 9, Issue 3 https://doi.org/10.1007/s11705-015-1525-3	journal	September 2015
Effects of carbon source and metabolic engineering on butyrate production in Escherichia coli Joung, Sea-Mi; Kurumbang, Nagendra Prasad; Sang, Byoung-In Korean Journal of Chemical Engineering, Vol. 28, Issue 7 https://doi.org/10.1007/s11814-011-0032-6	journal	June 2011
Effects of three main sugars in cane molasses on the production of butyric acid with Clostridium tyrobutyricum Huang, Lei; Xiang, Yijuan; Cai, Jin Korean Journal of Chemical Engineering, Vol. 28, Issue 12 https://doi.org/10.1007/s11814-011-0110-9	journal	September 2011
Production of Butyric Acid from Glucose and Xylose with Immobilized Cells of Clostridium tyrobutyricum in a Fibrous-bed Bioreactor Jiang, Ling; Wang, Jufang; Liang, Shizhong Applied Biochemistry and Biotechnology, Vol. 160, Issue 2 https://doi.org/10.1007/s12010-008-8305-1	journal	July 2008
Production of Sugars and Levulinic Acid from Marine Biomass Gelidium amansii Jeong, Gwi-Taek; Park, Don-Hee Applied Biochemistry and Biotechnology, Vol. 161, Issue 1-8 https://doi.org/10.1007/s12010-009-8795-5	journal	October 2009
Control and Optimization of Clostridium tyrobutyricum ATCC 25755 Adhesion into Fibrous Matrix in a Fibrous Bed Bioreactor Jiang, Ling; Wang, Jufang; Liang, Shizhong Applied Biochemistry and Biotechnology, Vol. 165, Issue 1 https://doi.org/10.1007/s12010-011-9236-9	journal	April 2011
Characterization of Clostridium thermocellum Isolates Grown on Cellulose and Sugarcane Bagasse Blume, Liana R.; Noronha, Eliane F.; Leite, Jackeline BioEnergy Research, Vol. 6, Issue 2 https://doi.org/10.1007/s12155-013-9295-6	journal	January 2013
Butyric acid production from brown algae using Clostridium tyrobutyricum ATCC 25755 Song, Ji-Hee; Ventura, Jey -R. S.; Lee, Chang-Hee Biotechnology and Bioprocess Engineering, Vol. 16, Issue 1 https://doi.org/10.1007/s12257-010-0177-x	journal	February 2011
Continuous Fermentation of Wheat Straw Hydrolysate by Clostridium tyrobutyricum with In-Situ Acids Removal Baroi, G. N.; Skiadas, I. V.; Westermann, P. Waste and Biomass Valorization, Vol. 6, Issue 3 https://doi.org/10.1007/s12649-015-9348-5	journal	January 2015
Enhanced production of butyric acid through immobilization of Clostridium tyrobutyricum in a novel inner disc-shaped matrix bioreactor Huang, Jin; Dai, Hongliang; Yan, Ren Annals of Microbiology, Vol. 66, Issue 1 https://doi.org/10.1007/s13213-015-1088-z	journal	May 2015
Natural flavours production: a biotechnological approach Armstrong, David W.; Yamazaki, Hiroshi Trends in Biotechnology, Vol. 4, Issue 10 https://doi.org/10.1016/0167-7799(86)90190-3	journal	October 1986
Butyric acid production from acid hydrolysate of corn fibre by Clostridium tyrobutyricum in a fibrous-bed bioreactor Zhu, Ying; Wu, Zetang; Yang, Shang-Tian Process Biochemistry, Vol. 38, Issue 5 https://doi.org/10.1016/S0032-9592(02)00162-0	journal	December 2002
Evaluation of solvent and pH for extractive fermentation of butyric acid Vandák, Dušan; Zigová, Jana; Šturdík, Ernest Process Biochemistry, Vol. 32, Issue 3 https://doi.org/10.1016/S0032-9592(96)00084-2	journal	March 1997
Butyric acid production by Clostridium butyricum with integrated extraction and pertraction Zigová, Jana; Šturdı́k, Ernest; Vandák, Dušan Process Biochemistry, Vol. 34, Issue 8 https://doi.org/10.1016/S0032-9592(99)00007-2	journal	October 1999
The late blowing in cheese: a new molecular approach based on PCR and DGGE to study the microbial ecology of the alteration process Cocolin, Luca; Innocente, Nadia; Biasutti, Marialuisa International Journal of Food Microbiology, Vol. 90, Issue 1 https://doi.org/10.1016/S0168-1605(03)00296-4	journal	January 2004
Identification of Clostridium tyrobutyricum and Related Species using Sugar Fermentation, Organic Acid Formation and DNA Probes Based on Specific 16S rRNA Sequences Klijn, N.; Bovie, C.; Dommes, J. Systematic and Applied Microbiology, Vol. 17, Issue 2 https://doi.org/10.1016/S0723-2020(11)80016-0	journal	August 1994
Identification of Clostridium butyricum, Clostridium sporogenes and Clostridium tyrobutyricum by Hybridization with 16S rRNA-targeted Oligonucleotide Probes Knabel, Stefan; Tatzel, Ralf; Ludwig, Wolfgang Systematic and Applied Microbiology, Vol. 20, Issue 1 https://doi.org/10.1016/S0723-2020(97)80052-5	journal	January 1997
Production of citric acid from molasses integrated with in-situ product separation by ion-exchange resin adsorption Jianlong, Wang; Xianghua, Wen; Ding, Zhou Bioresource Technology, Vol. 75, Issue 3 https://doi.org/10.1016/S0960-8524(00)00067-5	journal	December 2000
Production of carboxylic acids from hydrolyzed corn meal by immobilized cell fermentation in a fibrous-bed bioreactor Huang, Yu Liang; Wu, Zetang; Zhang, Likun Bioresource Technology, Vol. 82, Issue 1 https://doi.org/10.1016/S0960-8524(01)00151-1	journal	March 2002
Recovery of l-(+)-lactic acid by anion exchange resin Amberlite IRA-400 Cao, Xuejun; Yun, Hyun Shik; Koo, Yoon-Mo Biochemical Engineering Journal, Vol. 11, Issue 2-3 https://doi.org/10.1016/S1369-703X(02)00024-4	journal	September 2002
Adsorption of acetic acid on ion-exchange resins in non-aqueous conditions Anasthas, H. M.; Gaikar, V. G. Reactive and Functional Polymers, Vol. 47, Issue 1 https://doi.org/10.1016/S1381-5148(00)00066-3	journal	February 2001
Mixed organic acids as antibiotic substitutes improve performance, serum immunity, intestinal morphology and microbiota for weaned piglets Long, S. F.; Xu, Y. T.; Pan, L. Animal Feed Science and Technology, Vol. 235 https://doi.org/10.1016/j.anifeedsci.2017.08.018	journal	January 2018
Implications of butyrate and its derivatives for gut health and animal production Bedford, Andrea; Gong, Joshua Animal Nutrition, Vol. 4, Issue 2 https://doi.org/10.1016/j.aninu.2017.08.010	journal	June 2018
Fermentative production of butyric acid from paper mill sludge hydrolysates using Clostridium tyrobutyricum NRRL B-67062/RPT 4213 Liu, Siqing; Duncan, Shona; Qureshi, Nasib Biocatalysis and Agricultural Biotechnology, Vol. 14 https://doi.org/10.1016/j.bcab.2018.02.002	journal	April 2018
Continuous fermentation and kinetic experiments for the conversion of crude glycerol derived from second-generation biodiesel into 1,3 propanediol and butyric acid Varrone, Cristiano; Floriotis, Georgis; Heggeset, Tonje M. B. Biochemical Engineering Journal, Vol. 128 https://doi.org/10.1016/j.bej.2017.09.012	journal	December 2017
Biotechnological valorisation of raw glycerol discharged after bio-diesel (fatty acid methyl esters) manufacturing process: Production of 1,3-propanediol, citric acid and single cell oil Papanikolaou, Seraphim; Fakas, Stylianos; Fick, Michel Biomass and Bioenergy, Vol. 32, Issue 1 https://doi.org/10.1016/j.biombioe.2007.06.007	journal	January 2008
The effects of pH on carbon material and energy balances in hydrogen-producing Clostridium tyrobutyricum JM1 Jo, Ji Hye; Lee, Dae Sung; Park, Jong Moon Bioresource Technology, Vol. 99, Issue 17 https://doi.org/10.1016/j.biortech.2008.03.060	journal	November 2008
Butyric acid fermentation in a fibrous bed bioreactor with immobilized Clostridium tyrobutyricum from cane molasses Jiang, Ling; Wang, Jufang; Liang, Shizhong Bioresource Technology, Vol. 100, Issue 13 https://doi.org/10.1016/j.biortech.2009.02.032	journal	July 2009
Optimization of medium composition for butyric acid production by Clostridium thermobutyricum using response surface methodology Zhang, Chun-Hui; Ma, Yu-Jiu; Yang, Fang-Xiao Bioresource Technology, Vol. 100, Issue 18 https://doi.org/10.1016/j.biortech.2009.03.022	journal	September 2009
Efficient production of butyric acid from Jerusalem artichoke by immobilized Clostridium tyrobutyricum in a fibrous-bed bioreactor Huang, Jin; Cai, Jin; Wang, Jin Bioresource Technology, Vol. 102, Issue 4 https://doi.org/10.1016/j.biortech.2010.11.112	journal	February 2011
Refactoring redox cofactor regeneration for high-yield biocatalysis of glucose to butyric acid in Escherichia coli Lim, Jae Hyung; Seo, Sang Woo; Kim, Se Yeon Bioresource Technology, Vol. 135 https://doi.org/10.1016/j.biortech.2012.09.091	journal	May 2013
Butyric acid production from sugarcane bagasse hydrolysate by Clostridium tyrobutyricum immobilized in a fibrous-bed bioreactor Wei, Dong; Liu, Xiaoguang; Yang, Shang-Tian Bioresource Technology, Vol. 129 https://doi.org/10.1016/j.biortech.2012.11.065	journal	February 2013
Butyric acid from anaerobic fermentation of lignocellulosic biomass hydrolysates by Clostridium tyrobutyricum strain RPT-4213 Liu, Siqing; Bischoff, Kenneth M.; Leathers, Timothy D. Bioresource Technology, Vol. 143 https://doi.org/10.1016/j.biortech.2013.06.015	journal	September 2013
Production of medium-chain volatile fatty acids by mixed ruminal microorganisms is enhanced by ethanol in co-culture with Clostridium kluyveri Weimer, Paul J.; Nerdahl, Michael; Brandl, Dane J. Bioresource Technology, Vol. 175 https://doi.org/10.1016/j.biortech.2014.10.054	journal	January 2015
Electrochemical detoxification of phenolic compounds in lignocellulosic hydrolysate for Clostridium fermentation Lee, Kyung Min; Min, Kyoungseon; Choi, Okkyoung Bioresource Technology, Vol. 187 https://doi.org/10.1016/j.biortech.2015.03.129	journal	July 2015
Butanol and hexanol production in Clostridium carboxidivorans syngas fermentation: Medium development and culture techniques Phillips, John R.; Atiyeh, Hasan K.; Tanner, Ralph S. Bioresource Technology, Vol. 190 https://doi.org/10.1016/j.biortech.2015.04.043	journal	August 2015
Fermentation of sweet sorghum derived sugars to butyric acid at high titer and productivity by a moderate thermophile Clostridium thermobutyricum at 50 °C Wang, Liang; Ou, Mark S.; Nieves, Ismael Bioresource Technology, Vol. 198 https://doi.org/10.1016/j.biortech.2015.09.062	journal	December 2015
Butyric acid production from softwood hydrolysate by acetate-consuming Clostridium sp. S1 with high butyric acid yield and selectivity Kim, Minsun; Kim, Ki-Yeon; Lee, Kyung Min Bioresource Technology, Vol. 218 https://doi.org/10.1016/j.biortech.2016.07.073	journal	October 2016
Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing xylose catabolism genes for glucose and xylose co-utilization Fu, Hongxin; Yang, Shang-Tian; Wang, Minqi Bioresource Technology, Vol. 234 https://doi.org/10.1016/j.biortech.2017.03.073	journal	June 2017
Acetate-assisted increase of butyrate production by Eubacterium limosum KIST612 during carbon monoxide fermentation Park, Shinyoung; Yasin, Muhammad; Jeong, Jiyeong Bioresource Technology, Vol. 245 https://doi.org/10.1016/j.biortech.2017.08.132	journal	December 2017
Propionic acid production from soy molasses by Propionibacterium acidipropionici: Fermentation kinetics and economic analysis Yang, Hopen; Wang, Zhongqiang; Lin, Meng Bioresource Technology, Vol. 250 https://doi.org/10.1016/j.biortech.2017.11.016	journal	February 2018
Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing Class I heat shock protein GroESL Suo, Yukai; Fu, Hongxin; Ren, Mengmeng Bioresource Technology, Vol. 250 https://doi.org/10.1016/j.biortech.2017.11.059	journal	February 2018
Recent advances and strategies in process and strain engineering for the production of butyric acid by microbial fermentation Luo, Hongzhen; Yang, Rongling; Zhao, Yuping Bioresource Technology, Vol. 253 https://doi.org/10.1016/j.biortech.2018.01.007	journal	April 2018
Hyper-production of butyric acid from delignified rice straw by a novel consolidated bioprocess Chi, Xue; Li, Jianzheng; Wang, Xin Bioresource Technology, Vol. 254 https://doi.org/10.1016/j.biortech.2018.01.042	journal	April 2018
Recent advances in microbial production of fuels and chemicals using tools and strategies of systems metabolic engineering Cho, Changhee; Choi, So Young; Luo, Zi Wei Biotechnology Advances, Vol. 33, Issue 7 https://doi.org/10.1016/j.biotechadv.2014.11.006	journal	November 2015
Clostridium butyricum : from beneficial to a new emerging pathogen Cassir, N.; Benamar, S.; La Scola, B. Clinical Microbiology and Infection, Vol. 22, Issue 1 https://doi.org/10.1016/j.cmi.2015.10.014	journal	January 2016
Engineering clostridia for butanol production from biorenewable resources: from cells to process integration Wang, Jufang; Yang, Xiaorui; Chen, Chih-Chin Current Opinion in Chemical Engineering, Vol. 6 https://doi.org/10.1016/j.coche.2014.09.003	journal	November 2014
Microbial production of building block chemicals and polymers Lee, Jeong Wook; Kim, Hyun Uk; Choi, Sol Current Opinion in Biotechnology, Vol. 22, Issue 6 https://doi.org/10.1016/j.copbio.2011.02.011	journal	December 2011
Advancing metabolic engineering through systems biology of industrial microorganisms Dai, Zongjie; Nielsen, Jens Current Opinion in Biotechnology, Vol. 36 https://doi.org/10.1016/j.copbio.2015.08.006	journal	December 2015
Top value platform chemicals: bio-based production of organic acids Becker, Judith; Lange, Anna; Fabarius, Jonathan Current Opinion in Biotechnology, Vol. 36 https://doi.org/10.1016/j.copbio.2015.08.022	journal	December 2015
Recent advances in systems metabolic engineering tools and strategies Chae, Tong Un; Choi, So Young; Kim, Je Woong Current Opinion in Biotechnology, Vol. 47 https://doi.org/10.1016/j.copbio.2017.06.007	journal	October 2017
Studies on transport properties of short chain aliphatic carboxylicacids in electrodialytic separation Nagarale, R. K.; Gohil, G. S.; Shahi, V. K. Desalination, Vol. 171, Issue 2 https://doi.org/10.1016/j.desal.2004.06.190	journal	January 2005
Butyric acid and hydrogen production by Clostridium tyrobutyricum ATCC 25755 and mutants Liu, Xiaoguang; Zhu, Ying; Yang, Shang-Tian Enzyme and Microbial Technology, Vol. 38, Issue 3-4 https://doi.org/10.1016/j.enzmictec.2005.07.008	journal	February 2006
The effect of syngas composition on the growth and product formation of Butyribacterium methylotrophicum Heiskanen, Harri; Virkajärvi, Ilkka; Viikari, Liisa Enzyme and Microbial Technology, Vol. 41, Issue 3 https://doi.org/10.1016/j.enzmictec.2007.03.004	journal	August 2007
Relevance and analysis of butyric acid producing clostridia in milk and cheese Brändle, J.; Domig, K. J.; Kneifel, W. Food Control, Vol. 67 https://doi.org/10.1016/j.foodcont.2016.02.038	journal	September 2016
Production of butyric acid by Clostridium tyrobutyricum (ATCC25755) using sweet sorghum stalks and beet molasses Sjöblom, Magnus; Matsakas, Leonidas; Christakopoulos, Paul Industrial Crops and Products, Vol. 74 https://doi.org/10.1016/j.indcrop.2015.05.041	journal	November 2015
Fermentative production of butyric acid from wheat straw: Economic evaluation Baroi, G. N.; Gavala, H. N.; Westermann, P. Industrial Crops and Products, Vol. 104 https://doi.org/10.1016/j.indcrop.2017.04.008	journal	October 2017
Butyrate production under aerobic growth conditions by engineered Escherichia coli Kataoka, Naoya; Vangnai, Alisa S.; Pongtharangkul, Thunyarat Journal of Bioscience and Bioengineering, Vol. 123, Issue 5 https://doi.org/10.1016/j.jbiosc.2016.12.008	journal	May 2017
Effect of pH on metabolic pathway shift in fermentation of xylose by Clostridium tyrobutyricum Zhu, Ying; Yang, Shang-Tian Journal of Biotechnology, Vol. 110, Issue 2 https://doi.org/10.1016/j.jbiotec.2004.02.006	journal	May 2004
Genetic manipulation of butyrate formation pathways in Clostridium butyricum Cai, Guiqin; Jin, Bo; Saint, Christopher Journal of Biotechnology, Vol. 155, Issue 3 https://doi.org/10.1016/j.jbiotec.2011.07.004	journal	September 2011
Complete genome sequence of Clostridium butyricum JKY6D1 isolated from the pit mud of a Chinese flavor liquor-making factory Li, Changrun; Wang, Yansheng; Xie, Guopai Journal of Biotechnology, Vol. 220 https://doi.org/10.1016/j.jbiotec.2016.01.003	journal	February 2016
Enhanced butyric acid production in Clostridium tyrobutyricum by overexpression of rate-limiting enzymes in the Embden-Meyerhof-Parnas pathway Suo, Yukai; Fu, Hongxin; Ren, Mengmeng Journal of Biotechnology, Vol. 272-273 https://doi.org/10.1016/j.jbiotec.2018.02.012	journal	April 2018
Application of electrodialysis to the production of organic acids: State-of-the-art and recent developments Huang, Chuanhui; Xu, Tongwen; Zhang, Yaping Journal of Membrane Science, Vol. 288, Issue 1-2 https://doi.org/10.1016/j.memsci.2006.11.026	journal	February 2007
The ClosTron: A universal gene knock-out system for the genus Clostridium Heap, John T.; Pennington, Oliver J.; Cartman, Stephen T. Journal of Microbiological Methods, Vol. 70, Issue 3 https://doi.org/10.1016/j.mimet.2007.05.021	journal	September 2007
A modular system for Clostridium shuttle plasmids Heap, John T.; Pennington, Oliver J.; Cartman, Stephen T. Journal of Microbiological Methods, Vol. 78, Issue 1, p. 79-85 https://doi.org/10.1016/j.mimet.2009.05.004	journal	July 2009
The ClosTron: Mutagenesis in Clostridium refined and streamlined Heap, John T.; Kuehne, Sarah A.; Ehsaan, Muhammad Journal of Microbiological Methods, Vol. 80, Issue 1 https://doi.org/10.1016/j.mimet.2009.10.018	journal	January 2010
A two-plasmid inducible CRISPR/Cas9 genome editing tool for Clostridium acetobutylicum Wasels, François; Jean-Marie, Jennifer; Collas, Florent Journal of Microbiological Methods, Vol. 140 https://doi.org/10.1016/j.mimet.2017.06.010	journal	September 2017
Kinetics of butyric acid fermentation of glucose and xylose by Clostridium tyrobutyricum wild type and mutant Liu, Xiaoguang; Yang, Shang-Tian Process Biochemistry, Vol. 41, Issue 4 https://doi.org/10.1016/j.procbio.2005.10.009	journal	April 2006
In situ detoxification of lignocellulosic hydrolysate using a surfactant for butyric acid production by Clostridium tyrobutyricum ATCC 25755 Lee, Kyung Min; Kim, Ki-Yeon; Choi, Okkyoung Process Biochemistry, Vol. 50, Issue 4 https://doi.org/10.1016/j.procbio.2015.01.020	journal	April 2015
Butyric acid production with Clostridium tyrobutyricum immobilised to PVA gel Rebroš, Martin; Dolejš, Igor; Stloukal, Radek Process Biochemistry, Vol. 51, Issue 6 https://doi.org/10.1016/j.procbio.2016.03.003	journal	June 2016
Butyric acid production from oilseed rape straw by Clostridium tyrobutyricum immobilized in a fibrous bed bioreactor Huang, Jin; Zhu, Han; Tang, Wan Process Biochemistry, Vol. 51, Issue 12 https://doi.org/10.1016/j.procbio.2016.08.019	journal	December 2016
Maximizing the production of butyric acid from food waste as a precursor for ABE-fermentation Stein, Ullrich Heinz; Wimmer, B.; Ortner, M. Science of The Total Environment, Vol. 598 https://doi.org/10.1016/j.scitotenv.2017.04.139	journal	November 2017
Dissecting the assays to assess microbial tolerance to toxic chemicals in bioprocessing Zingaro, Kyle A.; Nicolaou, Sergios A.; Papoutsakis, Eleftherios T. Trends in Biotechnology, Vol. 31, Issue 11 https://doi.org/10.1016/j.tibtech.2013.08.005	journal	November 2013
Treatment, promotion, commotion: antibiotic alternatives in food-producing animals Allen, Heather K.; Levine, Uri Y.; Looft, Torey Trends in Microbiology, Vol. 21, Issue 3 https://doi.org/10.1016/j.tim.2012.11.001	journal	March 2013
Metabolic engineering of the non-sporulating, non-solventogenic Clostridium acetobutylicum strain M5 to produce butanol without acetone demonstrate the robustness of the acid-formation pathways and the importance of the electron balance Sillers, Ryan; Chow, Alison; Tracy, Bryan Metabolic Engineering, Vol. 10, Issue 6, p. 321-332 https://doi.org/10.1016/j.ymben.2008.07.005	journal	November 2008
A genomic-library based discovery of a novel, possibly synthetic, acid-tolerance mechanism in Clostridium acetobutylicum involving non-coding RNAs and ribosomal RNA processing Borden, Jacob R.; Jones, Shawn W.; Indurthi, Dinesh Metabolic Engineering, Vol. 12, Issue 3, p. 268-281 https://doi.org/10.1016/j.ymben.2009.12.004	journal	May 2010
Metabolic engineering of Clostridium tyrobutyricum for n-butanol production Yu, Mingrui; Zhang, Yali; Tang, I-Ching Metabolic Engineering, Vol. 13, Issue 4 https://doi.org/10.1016/j.ymben.2011.04.002	journal	July 2011
Metabolic engineering of Clostridium acetobutylicum for butyric acid production with high butyric acid selectivity Jang, Yu-Sin; Im, Jung Ae; Choi, So Young Metabolic Engineering, Vol. 23 https://doi.org/10.1016/j.ymben.2014.03.004	journal	May 2014
Metabolic and process engineering of Clostridium cellulovorans for biofuel production from cellulose Yang, Xiaorui; Xu, Mengmeng; Yang, Shang-Tian Metabolic Engineering, Vol. 32 https://doi.org/10.1016/j.ymben.2015.09.001	journal	November 2015
Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from glucose and xylose Fu, Hongxin; Yu, Le; Lin, Meng Metabolic Engineering, Vol. 40 https://doi.org/10.1016/j.ymben.2016.12.014	journal	March 2017
Exploiting endogenous CRISPR-Cas system for multiplex genome editing in Clostridium tyrobutyricum and engineer the strain for high-level butanol production Zhang, Jie; Zong, Wenming; Hong, Wei Metabolic Engineering, Vol. 47 https://doi.org/10.1016/j.ymben.2018.03.007	journal	May 2018
Importance of release location on the mode of action of butyrate derivatives in the avian gastrointestinal tract Moquet, P. C. A.; Onrust, L.; Van Immerseel, F. World's Poultry Science Journal, Vol. 72, Issue 1 https://doi.org/10.1017/S004393391500269X	journal	March 2016
DCEO Biotechnology: Tools To Design, Construct, Evaluate, and Optimize the Metabolic Pathway for Biosynthesis of Chemicals Chen, Xiulai; Gao, Cong; Guo, Liang Chemical Reviews, Vol. 118, Issue 1 https://doi.org/10.1021/acs.chemrev.6b00804	journal	April 2017
Tailoring the Oxidative Stress Tolerance of Clostridium tyrobutyricum CCTCC W428 by Introducing Trehalose Biosynthetic Capability Wu, Qian; Zhu, Liying; Xu, Qing Journal of Agricultural and Food Chemistry, Vol. 65, Issue 40 https://doi.org/10.1021/acs.jafc.7b03172	journal	September 2017
CRISPR/Cas9-Based Efficient Genome Editing in Clostridium ljungdahlii , an Autotrophic Gas-Fermenting Bacterium Huang, He; Chai, Changsheng; Li, Ning ACS Synthetic Biology, Vol. 5, Issue 12 https://doi.org/10.1021/acssynbio.6b00044	journal	June 2016
Bacterial Genome Editing with CRISPR-Cas9: Deletion, Integration, Single Nucleotide Modification, and Desirable “Clean” Mutant Selection in Clostridium beijerinckii as an Example Wang, Yi; Zhang, Zhong-Tian; Seo, Seung-Oh ACS Synthetic Biology, Vol. 5, Issue 7 https://doi.org/10.1021/acssynbio.6b00060	journal	April 2016
Part by Part: Synthetic Biology Parts Used in Solventogenic Clostridia Gyulev, Ivan S.; Willson, Benjamin J.; Hennessy, Rosanna C. ACS Synthetic Biology, Vol. 7, Issue 2 https://doi.org/10.1021/acssynbio.7b00327	journal	December 2017
Adaptation of Clostridium tyrobutyricum for Enhanced Tolerance to Butyric Acid in a Fibrous-Bed Bioreactor Zhu, Y.; Yang, S. -T. Biotechnology Progress, Vol. 19, Issue 2 https://doi.org/10.1021/bp025647x	journal	April 2003
Construction and Characterization of ack Deleted Mutant of Clostridium tyrobutyricum for Enhanced Butyric Acid and Hydrogen Production Liu, Xiaoguang; Zhu, Ying; Yang, Shang-Tian Biotechnology Progress, Vol. 22, Issue 5 https://doi.org/10.1021/bp060082g	journal	January 2006
Extraction of carboxylic acids with tertiary and quaternary amines: effect of pH Yang, Shang Tian; White, Scott A.; Hsu, Sheng Tsiung Industrial & Engineering Chemistry Research, Vol. 30, Issue 6 https://doi.org/10.1021/ie00054a040	journal	June 1991
Metabolic Engineering of Escherichia coli for Production of Butyric Acid Saini, Mukesh; Wang, Zei Wen; Chiang, Chung-Jen Journal of Agricultural and Food Chemistry, Vol. 62, Issue 19 https://doi.org/10.1021/jf500355p	journal	May 2014
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells Furusawa, Yukihiro; Obata, Yuuki; Fukuda, Shinji Nature, Vol. 504, Issue 7480 https://doi.org/10.1038/nature12721	journal	November 2013
Synthetic biology: applications come of age Khalil, Ahmad S.; Collins, James J. Nature Reviews Genetics, Vol. 11, Issue 5 https://doi.org/10.1038/nrg2775	journal	May 2010
Adaptive evolution: evaluating empirical support for theoretical predictions Olson-Manning, Carrie F.; Wagner, Maggie R.; Mitchell-Olds, Thomas Nature Reviews Genetics, Vol. 13, Issue 12 https://doi.org/10.1038/nrg3322	journal	November 2012
Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism Rose, Shannon; Bennuri, Sirish C.; Davis, Jakeira E. Translational Psychiatry, Vol. 8, Issue 1 https://doi.org/10.1038/s41398-017-0089-z	journal	February 2018
Fermentative hydrogen production from Jerusalem artichoke by Clostridium tyrobutyricum expressing exo-inulinase gene Jiang, Ling; Wu, Qian; Xu, Qing Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-07207-7	journal	August 2017
Advances in biotechnological production of butyric acid Zigová, J.; Šturdík, E. Journal of Industrial Microbiology & Biotechnology, Vol. 24, Issue 3 https://doi.org/10.1038/sj.jim.2900795	journal	March 2000
The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features Seedorf, H.; Fricke, W. F.; Veith, B. Proceedings of the National Academy of Sciences, Vol. 105, Issue 6 https://doi.org/10.1073/pnas.0711093105	journal	January 2008
Clostridium ljungdahlii represents a microbial production platform based on syngas Kopke, M.; Held, C.; Hujer, S. Proceedings of the National Academy of Sciences, Vol. 107, Issue 29, p. 13087-13092 https://doi.org/10.1073/pnas.1004716107	journal	July 2010
Clostridium thermobutyricum: growth studies and stimulation of butyrate formation by acetate supplementation Canganella, Francesco; Kuk, Seung-Uk; Morgan, Hugh Microbiological Research, Vol. 157, Issue 2 https://doi.org/10.1078/0944-5013-00140	journal	January 2002
Application of Wafer-Enhanced Electrodeionization in a Continuous Fermentation Process to Produce Butyric Acid with Clostridium tyrobutyricum Du, Jianjun; Lorenz, Nicole; Beitle, Robert R. Separation Science and Technology, Vol. 47, Issue 1 https://doi.org/10.1080/01496395.2011.618170	journal	January 2012
Butyrate: implications for intestinal function Leonel, Alda J.; Alvarez-Leite, Jacqueline I. Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 15, Issue 5 https://doi.org/10.1097/MCO.0b013e32835665fa	journal	January 2012
Clostridium thermobutyricum sp. nov., a Moderate Thermophile Isolated from a Cellulolytic Culture, That Produces Butyrate as the Major Product Wiegel, J.; Kuk, S. -U.; Kohring, G. W. International Journal of Systematic Bacteriology, Vol. 39, Issue 2 https://doi.org/10.1099/00207713-39-2-199	journal	April 1989
Taxonomy of the Clostridia: Wall Composition and DNA Homologies in Clostridium butyricum and Other Butyric Acid-producing Clostridia Cummins, C. S.; Johnson, J. L. Journal of General Microbiology, Vol. 67, Issue 1 https://doi.org/10.1099/00221287-67-1-33	journal	July 1971
Clostridium carboxidivorans sp. nov., a solvent-producing clostridium isolated from an agricultural settling lagoon, and reclassification of the acetogen Clostridium scatologenes strain SL1 as Clostridium drakei sp. nov. Liou, J. S. -C. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol. 55, Issue 5 https://doi.org/10.1099/ijs.0.63482-0	journal	September 2005
Clostridium pabulibutyricum sp. nov., a butyric-acid-producing organism isolated from high-moisture grass silage Kobayashi, Hisami; Nakasato, Takuya; Sakamoto, Mitsuo International Journal of Systematic and Evolutionary Microbiology, Vol. 67, Issue 12 https://doi.org/10.1099/ijsem.0.002387	journal	December 2017
Fermentative production of short-chain fatty acids in Escherichia coli Volker, Alexandra R.; Gogerty, David S.; Bartholomay, Christian Microbiology, Vol. 160, Issue 7 https://doi.org/10.1099/mic.0.078329-0	journal	July 2014
Butyric acid fermentation from pretreated and hydrolysed wheat straw by an adapted C lostridium tyrobutyricum strain: C. tyrobutyricum adaptation on straw hydrolysate Baroi, G. N.; Baumann, I.; Westermann, P. Microbial Biotechnology, Vol. 8, Issue 5 https://doi.org/10.1111/1751-7915.12304	journal	July 2015
Efficient Genome Editing in Clostridium cellulolyticum via CRISPR-Cas9 Nickase Xu, Tao; Li, Yongchao; Shi, Zhou Applied and Environmental Microbiology, Vol. 81, Issue 13 https://doi.org/10.1128/AEM.00873-15	journal	April 2015
Isolation and Characterization of an Anaerobic, Cellulolytic Bacterium, Clostridium cellulovorans sp. nov Sleat, Robert; Mah, Robert A.; Robinson, Ralph Applied and Environmental Microbiology, Vol. 48, Issue 1 https://doi.org/10.1128/AEM.48.1.88-93.1984	journal	January 1984
Effect of Acetate on Molecular and Physiological Aspects of Clostridium beijerinckii NCIMB 8052 Solvent Production and Strain Degeneration Chen, Chih-Kuang; Blaschek, Hans P. Applied and Environmental Microbiology, Vol. 65, Issue 2 https://doi.org/10.1128/AEM.65.2.499-505.1999	journal	February 1999
Acetate Utilization and Butyryl Coenzyme A (CoA):Acetate-CoA Transferase in Butyrate-Producing Bacteria from the Human Large Intestine Duncan, S. H.; Barcenilla, A.; Stewart, C. S. Applied and Environmental Microbiology, Vol. 68, Issue 10 https://doi.org/10.1128/AEM.68.10.5186-5190.2002	journal	October 2002
Genome Sequence of the Solvent-Producing Bacterium Clostridium carboxidivorans Strain P7T Paul, D.; Austin, F. W.; Arick, T. Journal of Bacteriology, Vol. 192, Issue 20, p. 5554-5555 https://doi.org/10.1128/JB.00877-10	journal	August 2010
Genome Sequence of the Cellulosome-Producing Mesophilic Organism Clostridium cellulovorans 743B Tamaru, Y.; Miyake, H.; Kuroda, K. Journal of Bacteriology, Vol. 192, Issue 3 https://doi.org/10.1128/JB.01450-09	journal	November 2009
Regulation of Carbon and Electron Flow in Clostridium butyricum VPI 3266 Grown on Glucose-Glycerol Mixtures Saint-Amans, Sylvie; Girbal, Laurence; Andrade, Jose Journal of Bacteriology, Vol. 183, Issue 5 https://doi.org/10.1128/JB.183.5.1748-1754.2001	journal	March 2001
Restricted Distribution of the Butyrate Kinase Pathway among Butyrate-Producing Bacteria from the Human Colon Louis, Petra; Duncan, Sylvia H.; McCrae, Sheila I. Journal of Bacteriology, Vol. 186, Issue 7 https://doi.org/10.1128/JB.186.7.2099-2106.2004	journal	April 2004
Draft Genome Sequence of the Butyric Acid Producer Clostridium tyrobutyricum Strain CIP I-776 (IFP923) Wasels, François; Clément, Benjamin; Lopes Ferreira, Nicolas Genome Announcements, Vol. 4, Issue 2 https://doi.org/10.1128/genomeA.00048-16	journal	April 2016
Draft Genome Sequences of Clostridium tyrobutyricum Strains FAM22552 and FAM22553, Isolated from Swiss Semihard Red-Smear Cheese Storari, Michelangelo; Wüthrich, Daniel; Bruggmann, Rémy Genome Announcements, Vol. 3, Issue 2 https://doi.org/10.1128/genomeA.00078-15	journal	April 2015
Genome Sequence of Clostridium tyrobutyricum ATCC 25755, a Butyric Acid-Overproducing Strain Jiang, L.; Zhu, L.; Xu, X. Genome Announcements, Vol. 1, Issue 3 https://doi.org/10.1128/genomeA.00308-13	journal	May 2013
Small RNAs in the Genus Clostridium Chen, Y.; Indurthi, D. C.; Jones, S. W. mBio, Vol. 2, Issue 1 https://doi.org/10.1128/mBio.00340-10	journal	December 2010
Deciphering Clostridium tyrobutyricum Metabolism Based on the Whole-Genome Sequence and Proteome Analyses Lee, Joungmin; Jang, Yu-Sin; Han, Mee-Jung mBio, Vol. 7, Issue 3 https://doi.org/10.1128/mBio.00743-16	journal	June 2016
Revealing the Bacterial Butyrate Synthesis Pathways by Analyzing (Meta)genomic Data Vital, Marius; Howe, Adina Chuang; Tiedje, James M. mBio, Vol. 5, Issue 2 https://doi.org/10.1128/mBio.00889-14	journal	April 2014
Converting Carbon Dioxide to Butyrate with an Engineered Strain of Clostridium ljungdahlii Ueki, Toshiyuki; Nevin, Kelly P.; Woodard, Trevor L. mBio, Vol. 5, Issue 5 https://doi.org/10.1128/mBio.01636-14	journal	October 2014
Construction of a butyrate-producing E. coli strain without the use of heterologous genes Seregina, T. A.; Shakulov, R. S.; Debabov, V. G. Applied Biochemistry and Microbiology, Vol. 46, Issue 8 https://doi.org/10.1134/S000368381008003X	journal	November 2010
Biosynthesis of butyric acid from cabbage stem and molasses by the strain Clostridium butyricum VKPM B-9619 Sushkova, V. I.; Zhukovskii, S. V.; Berezina, O. V. Russian Journal of Bioorganic Chemistry, Vol. 39, Issue 7 https://doi.org/10.1134/S1068162012070205	journal	November 2013
Microbial Production of Short Chain Fatty Acids from Lignocellulosic Biomass: Current Processes and Market Baumann, Ivan; Westermann, Peter BioMed Research International, Vol. 2016 https://doi.org/10.1155/2016/8469357	journal	January 2016
Transcription factors and genetic circuits orchestrating the complex, multilayered response of Clostridium acetobutylicum to butanol and butyrate stress Wang, Qinghua; Venkataramanan, Keerthi; Huang, Hongzhan BMC Systems Biology, Vol. 7, Issue 1 https://doi.org/10.1186/1752-0509-7-120	journal	January 2013
Bioconversion of lignocellulose: inhibitors and detoxification Jönsson, Leif J.; Alriksson, Björn; Nilvebrant, Nils-Olof Biotechnology for Biofuels, Vol. 6, Issue 1 https://doi.org/10.1186/1754-6834-6-16	journal	January 2013
Co-culturing a novel Bacillus strain with Clostridium tyrobutyricum ATCC 25755 to produce butyric acid from sucrose Dwidar, Mohammed; Kim, Seil; Jeon, Byoung Seung Biotechnology for Biofuels, Vol. 6, Issue 1 https://doi.org/10.1186/1754-6834-6-35	journal	January 2013
Radiation induces acid tolerance of Clostridium tyrobutyricum and enhances bioproduction of butyric acid through a metabolic switch Zhou, Xiang; Lu, Xi-Hong; Li, Xue-Hu Biotechnology for Biofuels, Vol. 7, Issue 1 https://doi.org/10.1186/1754-6834-7-22	journal	January 2014
Enhanced extraction of butyric acid under high-pressure CO2 conditions to integrate chemical catalysis for value-added chemicals and biofuels Chun, Jaesung; Choi, Okkyoung; Sang, Byoung-In Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1120-1	journal	April 2018
Production of butyric acid from acid hydrolysate of corn husk in fermentation by Clostridium tyrobutyricum: kinetics and process economic analysis Xiao, Zhiping; Cheng, Chu; Bao, Teng Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1165-1	journal	June 2018
Genome sequencing of Clostridium butyricum DKU-01, isolated from infant feces Mo, SangJoon; Kim, Bong-Soo; Yun, Sung-Jo Gut Pathogens, Vol. 7, Issue 1 https://doi.org/10.1186/s13099-015-0055-3	journal	March 2015
Engineered Production of Short Chain Fatty Acid in Escherichia coli Using Fatty Acid Synthesis Pathway Jawed, Kamran; Mattam, Anu Jose; Fatma, Zia PLOS ONE, Vol. 11, Issue 7 https://doi.org/10.1371/journal.pone.0160035	journal	July 2016
Consolidated Bioprocessing for Butyric Acid Production from Rice Straw with Undefined Mixed Culture Ai, Binling; Chi, Xue; Meng, Jia Frontiers in Microbiology, Vol. 7 https://doi.org/10.3389/fmicb.2016.01648	journal	October 2016
Continuous Fermentation of Clostridium tyrobutyricum with Partial Cell Recycle as a Long-Term Strategy for Butyric Acid Production Du, Jianjun; McGraw, Amy; Lorenz, Nicole Energies, Vol. 5, Issue 8 https://doi.org/10.3390/en5082835	journal	August 2012
Calcium butyrate: Anti-inflammatory effect on experimental colitis in rats and antitumor properties Celasco, Giuseppe; Moro, Luigi; Aiello, Caterina Biomedical Reports, Vol. 2, Issue 4 https://doi.org/10.3892/br.2014.273	journal	May 2014

Similar Records

Metabolic engineering of Escherichia coli for the production of butyric acid at high titer and productivity

Journal Article · Thu Mar 21 20:00:00 EDT 2019 · Biotechnology for Biofuels · OSTI ID:1613814

Fermentation of sweet sorghum derived sugars to butyric acid at high titer and productivity by a moderate thermophile Clostridium thermobutyricum at 50 °C

Journal Article · Fri Sep 25 20:00:00 EDT 2015 · Bioresource Technology · OSTI ID:1766805

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Biotechnology & Applied Microbiology
Butyric acid
Clostridia
Fermentation
Metabolic engineering
Product recovery
Renewable feedstock

Butyric acid: Applications and recent advances in its bioproduction

Citation Formats

References (171)

Similar Records

Related Subjects