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Complete Genome Sequence of Lactobacillus acidophilus FSI4, Isolated from Yogurt

Journal Article · · Genome Announcements
 [1];  [2];  [2];  [3]
  1. Novartis Inst. for Biomedical Research (NIBR), Cambridge, MA (United States); DOE/OSTI
  2. Fidelity Systems, Inc., Gaithersburg, MD (United States)
  3. Fidelity Systems, Inc., Gaithersburg, MD (United States); Winogradsky Inst. of Microbiology, Moscow (Russia)

A new Lactobacillus acidophilus strain, FSI4, isolated from yogurt, was isolated and sequenced in our laboratory. Our data, although supportive of previous conclusions regarding the remarkable stability of L. acidophilus species, indicate accumulating mutations in commercial L. acidophilus strains that warrant further study of the effect of damaged genes on the competitiveness of these bacteria in gut microbiota.

Research Organization:
Novartis Inst. for Biomedical Research (NIBR), Cambridge, MA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Engineering & Technology. Office of Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs
Grant/Contract Number:
FG02-98ER82577; FG02-00ER83009
OSTI ID:
1629957
Journal Information:
Genome Announcements, Journal Name: Genome Announcements Journal Issue: 2 Vol. 3; ISSN 2169-8287
Publisher:
American Society for MicrobiologyCopyright Statement
Country of Publication:
United States
Language:
English

References (14)

Carbohydrate metabolism in lactic acid bacteria journal January 1983
Genomic features of lactic acid bacteria effecting bioprocessing and health journal August 2005
The domestication of the probiotic bacterium Lactobacillus acidophilus journal November 2014
Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM journal January 2005
Comparative genomics of the lactic acid bacteria journal October 2006
S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions journal December 2008
PyroHMMvar: a sensitive and accurate method to call short indels and SNPs for Ion Torrent and 454 data journal August 2013
New Scientific Paradigms for Probiotics and Prebiotics journal January 2003
Velvet: Algorithms for de novo short read assembly using de Bruijn graphs journal February 2008
Complete Genome Sequence of Probiotic Strain Lactobacillus acidophilus La-14 journal May 2013
Draft Genome Sequences of Five Strains of Lactobacillus acidophilus, Strain CIP 76.13T, Isolated from Humans, Strains CIRM-BIA 442 and CIRM-BIA 445, Isolated from Dairy Products, and Strains DSM 20242 and DSM 9126 of Unknown Origin journal June 2013
Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth journal January 2008
Use of Fimers to Eliminate Polymerase Chain Reaction and Primer-Dimer Artifacts and to Increase Yield in BAC-Sequencing Reactions book January 2004
Finishing "Working Draft" BAC Projects by Directed Sequencing With ThermoFidelase and Fimers book January 2004

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