The obese gut microbiome across the epidemiologic transition

Dugas, Lara R.; Fuller, Miles; Gilbert, Jack; Layden, Brian T.

doi:10.1186/s12982-015-0044-5

The obese gut microbiome across the epidemiologic transition

Journal Article · Mon Jan 11 00:00:00 EST 2016 · Emerging themes in epidemiology

DOI:https://doi.org/10.1186/s12982-015-0044-5· OSTI ID:1629396

Dugas, Lara R. ^[1]; Fuller, Miles ^[2]; Gilbert, Jack ^[3]; Layden, Brian T. ^[4]

Loyola Univ., Chicago, Maywood, IL (United States). Stritch School of Medicine. Public Health Sciences; DOE/OSTI
Northwestern Univ., Evanston, IL (United States). Metabolism and Molecular Medicine. Division of Endocrinology
Argonne National Lab. (ANL), Argonne, IL (United States). Inst. for Genomic and Systems Biology. Biosciences Dept.; Univ. of Chicago, IL (United States). Dept. of Ecology and Evolution; Marine Biological Laboratory, Woods Hole, MA (United States); Zheijang Univ., Hangzhou (China). College of Environmental and Resources Sciences
Jesse Brown Veterans Affairs Medical Center, Chicago, IL (United States)

The obesity epidemic has emerged over the past few decades and is thought to be a result of both genetic and environmental factors. A newly identified factor, the gut microbiota, which is a bacterial ecosystem residing within the gastrointestinal tract of humans, has now been implicated in the obesity epidemic. Importantly, this bacterial community is impacted by external environmental factors through a variety of undefined mechanisms. We focus this review on how the external environment may impact the gut microbiota by considering, the host’s geographic location ‘human geography’, and behavioral factors (diet and physical activity). Moreover, we explore the relationship between the gut microbiota and obesity with these external factors. And finally, we highlight here how an epidemiologic model can be utilized to elucidate causal relationships between the gut microbiota and external environment independently and collectively, and how this will help further define this important new factor in the obesity epidemic.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1629396

Journal Information:: Emerging themes in epidemiology, Journal Name: Emerging themes in epidemiology Journal Issue: 1 Vol. 13; ISSN 1742-7622

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Prevalence of NIDDM Among Populations of the African Diaspora Cooper, R. S.; Rotimi, C. N.; Kaufman, J. S. Diabetes Care, Vol. 20, Issue 3 https://doi.org/10.2337/diacare.20.3.343	journal	March 1997
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Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women Dugas, Lara R.; Bernabé, Beatriz Peñalver; Priyadarshini, Medha Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-35230-9	journal	November 2018
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Ethnic and diet-related differences in the healthy infant microbiome Stearns, Jennifer C.; Zulyniak, Michael A.; de Souza, Russell J. Genome Medicine, Vol. 9, Issue 1 https://doi.org/10.1186/s13073-017-0421-5	journal	March 2017
Protective Effects of Anthocyanins in Obesity‐Associated Inflammation and Changes in Gut Microbiome Jayarathne, Shasika; Stull, April J.; Park, Oak‐Hee Molecular Nutrition & Food Research, Vol. 63, Issue 20 https://doi.org/10.1002/mnfr.201900149	journal	August 2019
Black Immigrants from Africa and the Caribbean Have Similar Rates of Diabetes but Africans Are Less Obese: the New York City Community Health Survey 2009–2013 Horlyck-Romanovsky, Margrethe F.; Fuster, Melissa; Echeverria, Sandra E. Journal of Racial and Ethnic Health Disparities, Vol. 6, Issue 3 https://doi.org/10.1007/s40615-019-00562-3	journal	February 2019
The influence of maternal and infant nutrition on cardiometabolic traits: novel findings and future research directions from four Canadian birth cohort studies de Souza, R. J.; Zulyniak, M. A.; Stearns, J. C. Proceedings of the Nutrition Society, Vol. 78, Issue 3 https://doi.org/10.1017/s0029665119000612	journal	May 2019
Body size phenotypes comprehensively assess cardiometabolic risk and refine the association between obesity and gut microbiota de la Cuesta-Zuluaga, J.; Corrales-Agudelo, V.; Carmona, J. A. International Journal of Obesity, Vol. 42, Issue 3 https://doi.org/10.1038/ijo.2017.281	journal	November 2017
Gut Microbial Divergence between Two Populations of the Hadal Amphipod Hirondellea gigas Zhang, Weipeng; Watanabe, Hiromi Kayama; Ding, Wei Applied and Environmental Microbiology, Vol. 85, Issue 1 https://doi.org/10.1128/aem.02032-18	journal	January 2019
Analysis of the fecal microbiota of fast- and slow-growing rainbow trout (Oncorhynchus mykiss) Chapagain, Pratima; Arivett, Brock; Cleveland, Beth M. BMC Genomics, Vol. 20, Issue 1 https://doi.org/10.1186/s12864-019-6175-2	journal	October 2019
Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population Koliada, Alexander; Syzenko, Ganna; Moseiko, Vladislav BMC Microbiology, Vol. 17, Issue 1 https://doi.org/10.1186/s12866-017-1027-1	journal	May 2017
Analysis of the fecal microbiota of fast- and slow-growing rainbow trout (Oncorhynchus mykiss) Chapagain, Pratima; Arivett, Brock; Cleveland, Beth M. Springer Nature https://doi.org/10.13016/1fbq-wswl	text	January 2019
Ethnic and diet-related differences in the healthy infant microbiome Stearns, Jennifer C.; Zulyniak, Michael A.; De Souza, Russell J. BioMed Central https://doi.org/10.14288/1.0366940	text	January 2018
Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women Dugas, Lr; Bernabé, Bp; Priyadarshini, Medha University of Illinois at Chicago https://doi.org/10.25417/uic.14888316	text	January 2021
Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women Dugas, Lr; Bernabé, Bp; Priyadarshini, Medha University of Illinois at Chicago https://doi.org/10.25417/uic.14888316.v1	text	January 2021

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