Microcapsule of sweet orange essential oil changes gut microbiota in diet-induced obese rats

Journal Article · Thu Nov 15 04:00:00 EST 2018 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2018.10.035· OSTI ID:23134063

Li, Dahu; Wu, Houjiu; Dou, Huating; Guo, Li ^[1]; Huang, Wei ^[2]

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1. Citrus Research Institute, Southwest University, Chongqing, 400715 (China)
2. College of Forestry and Life Science, Chongqing University of Arts and Sciences, Chongqing, 402160 (China)

Highlights: • Sweet orange essential oil (SOEO) microcapsules had weight loss effect on obese SD rats induced by high-fat diet. • SOEO microcapsules increased the relative abundance of Bifidobacterium (genus-level) in gut microbiota. • SOEO microcapsules protected gut barrier and decreased gut endotoxin levels by increasing the content of Bifidobacterium. Obesity is associated with the changes in gut microbiota. The aim of present study was to investigate the effects of sweet orange essential oil (SOEO) microcapsules on body weight and gut microbiota in obese rats induced by high-fat diet. By analyzing the body weight, fat rate and the sequence of cloned microbial small-subunit ribosomal RNA genes (16S rDNA) in rats fecal samples, we found that SOEO microcapsules decreased the body weight and increased the relative abundance of Bifidobacterium (genus-level) in gut microbiota. The analysis of endotoxin content proved that SOEO microcapsules protected gut barrier and decreased gut endotoxin levels by increasing the content of Bifidobacterium, then ameliorated low-grade inflammation, achieving the goal of losing weight. This might be the mechanism of SOEO microcapsules to lose body weight and provided a novel anti-obesity dietary supplement.

• OSTI ID: 23134063
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 4 Vol. 505; ISSN BBRCA9; ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ENDOTOXINS
ESSENTIAL OILS
INFLAMMATION
METABOLIC DISEASES
RATS
RIBOSOMAL RNA