Soluble dietary fiber improves energy homeostasis in obese mice by remodeling the gut microbiota

Journal Article · Thu Mar 15 04:00:00 EDT 2018 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2018.02.017· OSTI ID:23137259

Wang, Haiyuan ^[1]; Hong, Tao ^[2]; Li, Na; Zang, Bin; Wu, Xingmao ^[1]

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1. Intensive Care Unit, Shengjing Hospital of China Medical University, Shenyang, Liaoning (China)
2. Pain Manage Center, Shengjing Hospital of China Medical University, Shenyang, Liaoning (China)

Intervention with dietary fibers is an important strategy to combat the global epidemic of obesity which is a consequence of energy imbalance. However, a possible role of the gut microbiota in effects of dietary fibers on energy homeostasis remains unclear. Here, we treated a high fat diet-induced obese (DIO) mouse model with soluble dietary fiber. Our results showed that soluble dietary fiber reduced body weight gain and the excessive accumulation of white fat tissue in DIO mice. Notably, soluble dietary fiber increased energy expenditure, but not change energy intake in DIO mice. In accordance, 16S rRNA sequencing revealed that the diversity of the gut microbiota was restored by soluble dietary fiber. Moreover, compared with controls, soluble dietary fiber resulted in a decreased ratio of Firmicutes/Bacteroidetes at the phylum level, and an increased relative abundance of the genera Roseburia at the genus level. Taken together, these findings indicate that soluble dietary fiber improves energy homeostasis and prevents obesity by increasing the diversity of the gut microbiota and the colonization of beneficial bacteria.

• OSTI ID: 23137259
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 1 Vol. 498; ISSN 0006-291X; ISSN BBRCA9
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BACTERIA
ENERGY CONSUMPTION
HOMEOSTASIS
METABOLIC DISEASES
MICE