Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

MHC-Linked Syngeneic Developmental Preference in Thymic Lobes Colonized with Bone Marrow Cells: A Mathematical model

Journal Article · · Journal of Immunology Research
DOI:https://doi.org/10.1155/1998/65943· OSTI ID:1629356
 [1];  [2];  [3];  [4];  [5]
  1. Princeton Univ., NJ (United States). Dept. of Molecular Biology; DOE/OSTI
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  3. The Weizmann Inst. of Science, Rehovot (Israel). Dept. of Molecular Cell Biology
  4. The Weizmann Inst. of Science, Rehovot (Israel). Dept. of Applied Mathematics and Computer Science
  5. The Weizmann Inst. of Science, Rehovot (Israel). Dept. of Immunology
+ Show Author Affiliations
Reconstitution of the T-cell compartment after bone marrow transplantation depends on successful colonization of the thymus by bone-marrow-derived progenitor cells. Recent studies compared the development of syngeneic and allogeneic bone-marrow-derived cells in cocultures with lymphoid-depleted fetal thymus explants, leading to the discovery of MHC-linked syngeneic developmental preference (SDP) in the thymus. To determine the nature of cell interactions among the bone marrow and thymic elements that might underlie SDP, we analyzed this phenomenon by mathematical modeling. The results indicate that syngeneic mature T cells, responsible for inducing this preference, probably interfere both with the seeding of allogeneic bone-marrow-derived thymocyte progenitors in the thymic stroma and with their subsequent proliferation. In addition, the possibility of augmented death among the developing allogeneic thymocytes cannot be ruled out.
Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
Joseph P. and Jeanne M. Sullivan Foundation; National Institutes of Health (NIH); USDOE; United States-Israel Binational Science Foundation (BSF)
Grant/Contract Number:
AC52-06NA25396
OSTI ID:
1629356
Journal Information:
Journal of Immunology Research, Journal Name: Journal of Immunology Research Journal Issue: 4 Vol. 5; ISSN 2314-8861
Publisher:
HindawiCopyright Statement
Country of Publication:
United States
Language:
English

Cited By (3)

Toward Rigorous Comprehension of Biological Complexity: Modeling, Execution, and Visualization of Thymic T-Cell Maturation journal November 2003
Understanding natural killer cell regulation by mathematical approaches journal January 2012
A Monte Carlo Simulation for the Construction of Cytotoxic T Lymphocytes Repertoire book February 2011

Similar Records

T lymphocytes from irradiation chimeras repopulated with 13-day fetal liver cells recognize antigens only in association with self-MHC products
Journal Article · Tue Dec 31 23:00:00 EST 1985 · Journal of Molecular and Cellular Immunology; (USA) · OSTI ID:5601590
Thymic lymphocyte differentiation and thymic leukemogenesis
Journal Article · Mon Dec 31 23:00:00 EST 1984 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:5863272
Split tolerance in nude mice transplanted with 2'-deoxyguanosine-treated allogeneic thymus lobes
Journal Article · Tue Feb 28 23:00:00 EST 1989 · J. Immunol.; (United States) · OSTI ID:6324346

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
MHC
T-cell development
mathematical model
simulations
syngeneic preference
thymus