Influence of Dietary Potassium and Sodium/Potassium Molar Ratios on the Development of Salt Hypertension

Dahl, Lewis K.; Leitl, George; Heine, Martha

doi:10.1084/jem.136.2.318

Influence of Dietary Potassium and Sodium/Potassium Molar Ratios on the Development of Salt Hypertension

Journal Article · Tue Aug 01 00:00:00 EDT 1972 · Journal of Experimental Medicine

DOI:https://doi.org/10.1084/jem.136.2.318· OSTI ID:1629167

Dahl, Lewis K. ^[1]; Leitl, George ^[2]; Heine, Martha ^[2]

Brookhaven National Lab. (BNL), Upton, NY (United States). Medical Research Center; DOE/OSTI
Brookhaven National Lab. (BNL), Upton, NY (United States). Medical Research Center

Among genetically hypertension-prone rats, dietary sodium (chloride) was demonstrably hypertensinogenic and potassium (chloride) antihypertensinogenic. On diets containing the same NaCl but different KCl concentrations, mean blood pressure was greater in rats receiving less dietary potassium, i.e., diets with a higher Na/K molar ratio. On diets with different absolute concentrations of NaCl and KCl, but the same Na/K molar ratios, rats on the higher absolute NaCl intakes had the higher blood pressures. On diets with different absolute concentrations of NaCl and KCl, and different Na/K molar ratios, a group on a lower absolute NaCl intake but with a higher Na/K ratio could have more hypertension than a group on a higher absolute NaCl intake but with a lower Na/K ratio. At equivalent molar ratios, the respective effects of these two ions on blood pressure were dominated by that of sodium. It was concluded that the dietary Na/K molar ratio can be an important determinant for the severity, or even development, of salt-induced hypertension. Here, the mechanism of the moderating effect of potassium on sodium-induced hypertension was unclear.

View Accepted Manuscript (DOE)

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: SC0012704

OSTI ID:: 1629167

Journal Information:: Journal of Experimental Medicine, Journal Name: Journal of Experimental Medicine Journal Issue: 2 Vol. 136; ISSN 0022-1007

Publisher:: Rockefeller University PressCopyright Statement

Country of Publication:: United States

Language:: English

Cited By (20)

Chronic high-sodium diet intake after weaning lead to neurogenic hypertension in adult Wistar rats Gomes, Paula Magalhães; Sá, Renato Willian Martins; Aguiar, Giovana Lopes Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-05984-9	journal	July 2017
Natural sea salt consumption confers protection against hypertension and kidney damage in Dahl salt-sensitive rats Lee, Bog-Hieu; Yang, Ae-Ri; Kim, Mi Young Food & Nutrition Research, Vol. 61, Issue 1 https://doi.org/10.1080/16546628.2017.1264713	journal	December 2016
Controlled trial of long term oral potassium supplements in patients with mild hypertension. Siani, A.; Strazzullo, P.; Russo, L. BMJ, Vol. 294, Issue 6585 https://doi.org/10.1136/bmj.294.6585.1453	journal	June 1987
Cost-effectiveness of reducing salt intake in the Pacific Islands: protocol for a before and after intervention study Webster, Jacqui; Snowdon, Wendy; Moodie, Marj BMC Public Health, Vol. 14, Issue 1 https://doi.org/10.1186/1471-2458-14-107	journal	February 2014
Micronutrient Adequacy in Preschool Children Attending Family Child Care Homes No authors listed Nutrients, Vol. 11, Issue 9 https://doi.org/10.3390/nu11092134	journal	September 2019
Sodium intake and prevalence of hypertension, coronary heart disease, and stroke in Korean adults Park, Junhyung; Kwock, Chang Keun Journal of Ethnic Foods, Vol. 2, Issue 3 https://doi.org/10.1016/j.jef.2015.08.007	journal	September 2015
Enteric dysbiosis-linked gut barrier disruption triggers early renal injury induced by chronic high salt feeding in mice Hu, Jingjuan; Luo, Haihua; Wang, Jieyan Experimental & Molecular Medicine, Vol. 49, Issue 8 https://doi.org/10.1038/emm.2017.122	journal	August 2017
Developmental windows and environment as important factors in the expression of genetic information: a cardiovascular physiologist's view Kuneš, Jaroslav; Zicha, Josef Clinical Science, Vol. 111, Issue 5 https://doi.org/10.1042/cs20050271	journal	October 2006
Genetically determined chloride-sensitive hypertension and stroke Tanaka, M.; Schmidlin, O.; Yi, S. -L. Proceedings of the National Academy of Sciences, Vol. 94, Issue 26 https://doi.org/10.1073/pnas.94.26.14748	journal	December 1997
Biochemical validation of a self-administered semi-quantitative food-frequency questionnaire Porrini, M.; Gentile, M. G.; Fidanza, F. British Journal of Nutrition, Vol. 74, Issue 3 https://doi.org/10.1079/bjn19950138	journal	September 1995
Relationship and Interaction between Sodium and Potassium Morris, R. Curtis; Schmidlin, Olga; Frassetto, Lynda A. Journal of the American College of Nutrition, Vol. 25, Issue sup3 https://doi.org/10.1080/07315724.2006.10719576	journal	June 2006
Estimating 24-h urinary sodium/potassium ratio from casual (‘spot’) urinary sodium/potassium ratio: the INTERSALT Study Iwahori, Toshiyuki; Miura, Katsuyuki; Ueshima, Hirotsugu International Journal of Epidemiology https://doi.org/10.1093/ije/dyw287	journal	December 2016
Preventive dietary potassium supplementation in young salt-sensitive Dahl rats attenuates development of salt hypertension by decreasing sympathetic vasoconstriction: Age-dependent prevention of salt hypertension by dietary potassium Zicha, J.; Dobešová, Z.; Behuliak, M. Acta Physiologica, Vol. 202, Issue 1 https://doi.org/10.1111/j.1748-1716.2010.02248.x	journal	March 2011
Salt-sensing mechanisms in blood pressure regulation and hypertension Orlov, Sergei N.; Mongin, Alexander A. American Journal of Physiology-Heart and Circulatory Physiology, Vol. 293, Issue 4 https://doi.org/10.1152/ajpheart.00325.2007	journal	October 2007
Ontogenetic Aspects of Hypertension Development: Analysis in the Rat Zicha, Josef; Kuneš, Jaroslav Physiological Reviews, Vol. 79, Issue 4 https://doi.org/10.1152/physrev.1999.79.4.1227	journal	January 1999
Cardiovascular and humoral responses to extremes of sodium intake in normal black and white men. Luft, F. C.; Rankin, L. I.; Bloch, R. Circulation, Vol. 60, Issue 3 https://doi.org/10.1161/01.cir.60.3.697	journal	September 1979
Dahl salt-susceptible and salt-resistant rats. A review. Rapp, J. P. Hypertension, Vol. 4, Issue 6 https://doi.org/10.1161/01.hyp.4.6.753	journal	November 1982
Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Rapp, J. P.; Dene, H. Hypertension, Vol. 7, Issue 3_pt_1 https://doi.org/10.1161/01.hyp.7.3.340	journal	May 1985
Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Rapp, J. P.; Dene, H. Hypertension, Vol. 7, Issue 3_Pt_1 https://doi.org/10.1161/01.hyp.7.3_pt_1.340	journal	May 1985
Role of Dietary K ⁺ in Natriuresis, Blood Pressure Reduction, Cardiovascular Protection, and Renoprotection Gritter, Martin; Rotmans, Joris I.; Hoorn, Ewout J. Hypertension, Vol. 73, Issue 1 https://doi.org/10.1161/hypertensionaha.118.11209	journal	January 2019

Similar Records

Dietary sodium, psychic stress, and genetic predisposition to experimental hypertension

Journal Article · Fri Dec 31 23:00:00 EST 1976 · Proc. Soc. Exp. Biol. Med.; (United States) · OSTI ID:6802219

The effect dietary Cu intake on the development of hypertension in the Dahl-S rat

Journal Article · Wed Feb 08 23:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA) · OSTI ID:6832884

Further Evidence of the Toxicity of NaCl

Journal Article · Thu Feb 28 20:00:00 EDT 1974 · Journal of Experimental Medicine · OSTI ID:1629135

Related Subjects

59 BASIC BIOLOGICAL SCIENCES

Influence of Dietary Potassium and Sodium/Potassium Molar Ratios on the Development of Salt Hypertension

Citation Formats

Cited By (20)

Similar Records

Related Subjects