Dietary sodium, psychic stress, and genetic predisposition to experimental hypertension

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-155-39827· OSTI ID:6802219

Friedman, R; Iwai, J

Rats with a genetic susceptibility to hypertension were exposed for 26 weeks to the stress of a chronic food-shock conflict while being fed a diet containing 2% NaCl. The rats developed modest elevations in blood pressure. These elevations were greater than those previously observed in conflict-exposed rats fed a very-low-sodium diet and much greater than those observed in unstressed rats fed 2% NaCl ad libitum. However, the elevations in blood pressure were less severe than those usually exhibited by genetically similar rats fed a diet containing 4 or 8% NaCl without the superimposition of psychological stress. The results suggest that, although psychological stress can synergistically interact with sodium, its hypertensinogenic potency remains conjectural.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 6802219
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 155; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BIOLOGY
BLOOD PRESSURE
CARDIOVASCULAR DISEASES
CHLORIDES
CHLORINE COMPOUNDS
DIET
DISEASES
GENETICS
HALIDES
HALOGEN COMPOUNDS
HYPERTENSION
MAMMALS
RATS
RODENTS
SODIUM CHLORIDES
SODIUM COMPOUNDS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES