Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni

Kumar, Anand; Gangaiah, Dharanesh; Torrelles, Jordi B.; Rajashekara, Gireesh

doi:10.3748/wjg.v22.i33.7402

Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni

Journal Article · Wed Sep 07 00:00:00 EDT 2016 · World Journal of Gastroenterology

DOI:https://doi.org/10.3748/wjg.v22.i33.7402· OSTI ID:1628601

Kumar, Anand ^[1]; Gangaiah, Dharanesh ^[2]; Torrelles, Jordi B. ^[3]; Rajashekara, Gireesh ^[3]

The Ohio State Univ., Columbus, OH (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States); DOE/OSTI
Indiana Univ. School of Medicine, Indianapolis, IN (United States)
The Ohio State Univ., Columbus, OH (United States)

Campylobacter jejuni (C. jejuni), a Gram-negative microaerophilic bacterium, is a predominant cause of bacterial foodborne gastroenteritis in humans worldwide. Despite its importance as a major foodborne pathogen, our understanding of the molecular mechanisms underlying C. jejuni stress survival and pathogenesis is limited. Inorganic polyphosphate (poly P) has been shown to play significant roles in bacterial resistance to stress and virulence in many pathogenic bacteria. C. jejuni contains the complete repertoire of enzymes required for poly P metabolism. Recent work in our laboratory and others have demonstrated that poly P controls a plethora of C. jejuni properties that impact its ability to survive in the environment as well as to colonize/infect mammalian hosts. This review article summarizes the current literature on the role of poly P in C. jejuni stress survival and virulence and discusses on how poly P-related enzymes can be exploited for therapeutic/prevention purposes. Additionally, the review article identifies potential areas for future investigation that would enhance our understanding of the role of poly P in C. jejuni and other bacteria, which ultimately would facilitate design of effective therapeutic/preventive strategies to reduce not only the burden of C. jejuni-caused foodborne infections but also of other bacterial infections in humans.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: Agriculture and Food Research Initiative (AFRI); USDOE Office of Science (SC)

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1628601

Journal Information:: World Journal of Gastroenterology, Journal Name: World Journal of Gastroenterology Journal Issue: 33 Vol. 22; ISSN 1007-9327; ISSN applab

Publisher:: Baishideng Publishing Group Inc.Copyright Statement

Country of Publication:: United States

Language:: English

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Phosphate transporter PstSCAB of Campylobacter jejuni is essential for lactate-dependent growth and colonization in chickens Sinha, Ritam; LeVeque, Rhiannon M.; Bowlin, Marvin Q. BioRxiv https://doi.org/10.1101/843771	journal	November 2019
Catalytic properties of wheat phytase that favorably degrades long-chain inorganic polyphosphate An, Jeongmin; Cho, Jaiesoon Asian-Australasian Journal of Animal Sciences, Vol. 33, Issue 1 https://doi.org/10.5713/ajas.19.0047	journal	January 2020
The acid phosphatase Pho5 of Saccharomyces cerevisiae is not involved in polyphosphate breakdown Andreeva, Nadeshda; Ledova, Larisa; Ryasanova, Lubov Folia Microbiologica, Vol. 64, Issue 6 https://doi.org/10.1007/s12223-019-00702-6	journal	April 2019
The Reduced Level of Inorganic Polyphosphate Mobilizes Antioxidant and Manganese-Resistance Systems in Saccharomyces cerevisiae Trilisenko, Ludmila; Zvonarev, Anton; Valiakhmetov, Airat Cells, Vol. 8, Issue 5 https://doi.org/10.3390/cells8050461	journal	May 2019

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59 BASIC BIOLOGICAL SCIENCES
Campylobacter jejuni
Colonization/infection
Gastroenterology & Hepatology
Inorganic polyphosphate
Stress tolerance
Virulence

Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni

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