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Iron Oxide Nanocrystals for Magnetic Hyperthermia Applications

Journal Article · · Nanomaterials
DOI:https://doi.org/10.3390/nano2020134· OSTI ID:1628498
 [1];  [2];  [2];  [2];  [2];  [2];  [2];  [2];  [2];  [3];  [4];  [5];  [6];  [2]
  1. Univ. of New Mexico, Albuquerque, NM (United States). Center for High Technology Materials; DOE/OSTI
  2. Univ. of New Mexico, Albuquerque, NM (United States). Center for High Technology Materials
  3. Univ. of New Mexico, Albuquerque, NM (United States). Health Sciences Center. Dept. of Biochemistry and Molecular Biology
  4. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Nanomaterials Sciences
  5. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Center for Integrated Nanotechnologies
  6. Univ. of Texas, Austin, TX (United States). College of Pharmacy
+ Show Author Affiliations

Magnetic nanocrystals have been investigated extensively in the past several years for several potential applications, such as information technology, MRI contrast agents, and for drug conjugation and delivery. A specific property of interest in biomedicine is magnetic hyperthermia—an increase in temperature resulting from the thermal energy released by magnetic nanocrystals in an external alternating magnetic field. Iron oxide nanocrystals of various sizes and morphologies were synthesized and tested for specific losses (heating power) using frequencies of 111.1 kHz and 629.2 kHz, and corresponding magnetic field strengths of 9 and 25 mT. Polymorphous nanocrystals as well as spherical nanocrystals and nanowires in paramagnetic to ferromagnetic size range exhibited good heating power. A remarkable 30 °C temperature increase was observed in a nanowire sample at 111 kHz and magnetic field of 25 mT (19.6 kA/m), which is very close to the typical values of 100 kHz and 20 mT used in medical treatments.

Research Organization:
Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
Grant/Contract Number:
AC04-94AL85000
OSTI ID:
1628498
Journal Information:
Nanomaterials, Journal Name: Nanomaterials Journal Issue: 2 Vol. 2; ISSN 2079-4991; ISSN NANOKO
Publisher:
MDPICopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (5)

Radiofrequency Remote Control of Thermolysin Activity journal January 2019
Antibacterial activity of iron oxide, iron nitride, and tobramycin conjugated nanoparticles against Pseudomonas aeruginosa biofilms journal February 2020
Novel Bi-Functional 14-mer Peptides with Both Ovarian Carcinoma Cells Targeting and Magnetic Fe3O4Nanoparticles Affinity journal March 2019
Iron Oxide Nanoparticles in Photothermal Therapy journal June 2018
From wustite to hematite: thermal transformation of differently sized iron oxide nanoparticles in air journal July 2019

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Materials Science
Science & Technology - Other Topics
ferrofluid
hyperthermia
iron oxide nanocrystals
thermotherapy