Magnetic nanoparticles for medical applications: Progress and challenges

Journal Article · Wed Nov 13 00:00:00 EST 2013 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4832806· OSTI ID:22280636

Doaga, A.; Cojocariu, A. M.; Constantin, C. P.; Caltun, O. F. ^[1]; Hempelmann, R. ^[2]

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1. Faculty of Physics, Alexandru Ioan Cuza University, Bd. Carol I. Nr. 11, Iasi, 700506 (Romania)
2. Physical Chemistry Department, Saarland University, 66123 Saarbrücken (Germany)

Magnetic nanoparticles present unique properties that make them suitable for applications in biomedical field such as magnetic resonance imaging (MRI), hyperthermia and drug delivery systems. Magnetic hyperthermia involves heating the cancer cells by using magnetic particles exposed to an alternating magnetic field. The cell temperature increases due to the thermal propagation of the heat induced by the nanoparticles into the affected region. In order to increase the effectiveness of the treatment hyperthermia can be combined with drug delivery techniques. As a spectroscopic technique MRI is used in medicine for the imaging of tissues especially the soft ones and diagnosing malignant or benign tumors. For this purpose Zn{sub x}Co{sub 1−x}Fe{sub 2}O{sub 4} ferrite nanoparticles with x between 0 and 1 have been prepared by co-precipitation method. The cristallite size was determined by X-ray diffraction, while the transmission electron microscopy illustrates the spherical shape of the nanoparticles. Magnetic characterizations of the nanoparticles were carried out at room temperature by using a vibrating sample magnetometer. The specific absorption rate (SAR) was measured by calorimetric method at different frequencies and it has been observed that this value depends on the chemical formula, the applied magnetic fields and the frequency. The study consists of evaluating the images, obtained from an MRI facility, when the nanoparticles are dispersed in agar phantoms compared with the enhanced ones when Omniscan was used as contrast agent. Layer-by-layer technique was used to achieve the necessary requirement of biocompatibility. The surface of the magnetic nanoparticles was modified by coating it with oppositely charged polyelectrolites, making it possible for the binding of a specific drug.

• OSTI ID: 22280636
• Journal Information: AIP Conference Proceedings, Vol. 1564, Issue 1; Conference: TIM 2012 physics conference, Timisoara (Romania), 27-30 Nov 2012; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

77 NANOSCIENCE AND NANOTECHNOLOGY
60 APPLIED LIFE SCIENCES
AGAR
ANIMAL TISSUES
CALORIMETRY
COBALT COMPOUNDS
COMPARATIVE EVALUATIONS
COPRECIPITATION
DRUGS
FERRITES
HYPERTHERMIA
MAGNETIC FIELDS
NANOSTRUCTURES
NEOPLASMS
NMR IMAGING
PARTICLES
PHANTOMS
TEMPERATURE RANGE 0273-0400 K
TRANSMISSION ELECTRON MICROSCOPY
VIBRATING SAMPLE MAGNETOMETERS
X-RAY DIFFRACTION
ZINC COMPOUNDS